PEGDA drug delivery scaffolds prepared with UV curing process

Individually tailored drug delivery systems (DDSs) are considered one of the most promising therapeutic tools for the creation of safe and effective treatments. DDSs as a novel approach should be beneficial in curing systemic as well as local ailments, where a high topical concentration of the drug...

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Autores principales:	Rekowska Natalia, Konasch Jan, Riess Alexander, Mau Robert, Eickner Thomas, Seitz Hermann, Grabow Niels, Teske Michael
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2020
Materias:	drug delivery system (dds) poly(ethylene glycol) diacrylate (pegda) acetylsalicylic acid (asa) release Medicine R
Acceso en línea:	https://doaj.org/article/ce548eb3a0014939b3b407d4ac403834
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spelling	oai:doaj.org-article:ce548eb3a0014939b3b407d4ac4038342021-12-05T14:10:42ZPEGDA drug delivery scaffolds prepared with UV curing process2364-550410.1515/cdbme-2020-3049https://doaj.org/article/ce548eb3a0014939b3b407d4ac4038342020-09-01T00:00:00Zhttps://doi.org/10.1515/cdbme-2020-3049https://doaj.org/toc/2364-5504Individually tailored drug delivery systems (DDSs) are considered one of the most promising therapeutic tools for the creation of safe and effective treatments. DDSs as a novel approach should be beneficial in curing systemic as well as local ailments, where a high topical concentration of the drug and a reduction of side effects are desirable. It could also be favorable for patients requiring customized treatments, showing atypical profiles of drug metabolism. Development of particular drug delivery devices require the selection of a suitable scaffold material, which should exhibit proper mechanical and biological properties, but also enable adjustment of the drug release according to a specific need. Thus, it is extremely important to expand the knowledge concerning potential DDS components. Poly(ethylene glycol) diacrylate (PEGDA) according to its properties can be easily used as a DDS resin and shaped into a desired structure with the employment of techniques based on photopolymerization, including some novel 3D printing techniques. As a continuation of our previous works, in this paper drug release studies from conventionally prepared PEGDA scaffolds are presented. We have shown that in PEGDA materials, the release profile of the low molecular weight model drug acetylsalicylic acid can be altered by water content. PEGDA as a delivery material should be further investigated to specify its potential as a comonomer and a matrix for pharmaceutical agents.Rekowska NataliaKonasch JanRiess AlexanderMau RobertEickner ThomasSeitz HermannGrabow NielsTeske MichaelDe Gruyterarticledrug delivery system (dds)poly(ethylene glycol) diacrylate (pegda)acetylsalicylic acid (asa) releaseMedicineRENCurrent Directions in Biomedical Engineering, Vol 6, Iss 3, Pp 193-195 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	drug delivery system (dds) poly(ethylene glycol) diacrylate (pegda) acetylsalicylic acid (asa) release Medicine R
spellingShingle	drug delivery system (dds) poly(ethylene glycol) diacrylate (pegda) acetylsalicylic acid (asa) release Medicine R Rekowska Natalia Konasch Jan Riess Alexander Mau Robert Eickner Thomas Seitz Hermann Grabow Niels Teske Michael PEGDA drug delivery scaffolds prepared with UV curing process
description	Individually tailored drug delivery systems (DDSs) are considered one of the most promising therapeutic tools for the creation of safe and effective treatments. DDSs as a novel approach should be beneficial in curing systemic as well as local ailments, where a high topical concentration of the drug and a reduction of side effects are desirable. It could also be favorable for patients requiring customized treatments, showing atypical profiles of drug metabolism. Development of particular drug delivery devices require the selection of a suitable scaffold material, which should exhibit proper mechanical and biological properties, but also enable adjustment of the drug release according to a specific need. Thus, it is extremely important to expand the knowledge concerning potential DDS components. Poly(ethylene glycol) diacrylate (PEGDA) according to its properties can be easily used as a DDS resin and shaped into a desired structure with the employment of techniques based on photopolymerization, including some novel 3D printing techniques. As a continuation of our previous works, in this paper drug release studies from conventionally prepared PEGDA scaffolds are presented. We have shown that in PEGDA materials, the release profile of the low molecular weight model drug acetylsalicylic acid can be altered by water content. PEGDA as a delivery material should be further investigated to specify its potential as a comonomer and a matrix for pharmaceutical agents.
format	article
author	Rekowska Natalia Konasch Jan Riess Alexander Mau Robert Eickner Thomas Seitz Hermann Grabow Niels Teske Michael
author_facet	Rekowska Natalia Konasch Jan Riess Alexander Mau Robert Eickner Thomas Seitz Hermann Grabow Niels Teske Michael
author_sort	Rekowska Natalia
title	PEGDA drug delivery scaffolds prepared with UV curing process
title_short	PEGDA drug delivery scaffolds prepared with UV curing process
title_full	PEGDA drug delivery scaffolds prepared with UV curing process
title_fullStr	PEGDA drug delivery scaffolds prepared with UV curing process
title_full_unstemmed	PEGDA drug delivery scaffolds prepared with UV curing process
title_sort	pegda drug delivery scaffolds prepared with uv curing process
publisher	De Gruyter
publishDate	2020
url	https://doaj.org/article/ce548eb3a0014939b3b407d4ac403834
work_keys_str_mv	AT rekowskanatalia pegdadrugdeliveryscaffoldspreparedwithuvcuringprocess AT konaschjan pegdadrugdeliveryscaffoldspreparedwithuvcuringprocess AT riessalexander pegdadrugdeliveryscaffoldspreparedwithuvcuringprocess AT maurobert pegdadrugdeliveryscaffoldspreparedwithuvcuringprocess AT eicknerthomas pegdadrugdeliveryscaffoldspreparedwithuvcuringprocess AT seitzhermann pegdadrugdeliveryscaffoldspreparedwithuvcuringprocess AT grabowniels pegdadrugdeliveryscaffoldspreparedwithuvcuringprocess AT teskemichael pegdadrugdeliveryscaffoldspreparedwithuvcuringprocess
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PEGDA drug delivery scaffolds prepared with UV curing process

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