Quantification of ongoing APOBEC3A activity in tumor cells by monitoring RNA editing at hotspots

The DNA cytosine deaminases APOBEC3A and APOBEC3B have emerged from cancer genomics studies as drivers of mutation in cancers and tumor heterogeneity. Here the authors present a computational approach to identify the RNA mutations specifically driven by APOBEC3A, and developed an RNA mutation-based...

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Autores principales:	Pégah Jalili, Danae Bowen, Adam Langenbucher, Shinho Park, Kevin Aguirre, Ryan B. Corcoran, Angela G. Fleischman, Michael S. Lawrence, Lee Zou, Rémi Buisson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ce56509c93e8439dabb97f9c99412c8c
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spelling	oai:doaj.org-article:ce56509c93e8439dabb97f9c99412c8c2021-12-02T17:52:29ZQuantification of ongoing APOBEC3A activity in tumor cells by monitoring RNA editing at hotspots10.1038/s41467-020-16802-82041-1723https://doaj.org/article/ce56509c93e8439dabb97f9c99412c8c2020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16802-8https://doaj.org/toc/2041-1723The DNA cytosine deaminases APOBEC3A and APOBEC3B have emerged from cancer genomics studies as drivers of mutation in cancers and tumor heterogeneity. Here the authors present a computational approach to identify the RNA mutations specifically driven by APOBEC3A, and developed an RNA mutation-based assay to quantify ongoing APOBEC3A activity in tumor cells.Pégah JaliliDanae BowenAdam LangenbucherShinho ParkKevin AguirreRyan B. CorcoranAngela G. FleischmanMichael S. LawrenceLee ZouRémi BuissonNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Pégah Jalili Danae Bowen Adam Langenbucher Shinho Park Kevin Aguirre Ryan B. Corcoran Angela G. Fleischman Michael S. Lawrence Lee Zou Rémi Buisson Quantification of ongoing APOBEC3A activity in tumor cells by monitoring RNA editing at hotspots
description	The DNA cytosine deaminases APOBEC3A and APOBEC3B have emerged from cancer genomics studies as drivers of mutation in cancers and tumor heterogeneity. Here the authors present a computational approach to identify the RNA mutations specifically driven by APOBEC3A, and developed an RNA mutation-based assay to quantify ongoing APOBEC3A activity in tumor cells.
format	article
author	Pégah Jalili Danae Bowen Adam Langenbucher Shinho Park Kevin Aguirre Ryan B. Corcoran Angela G. Fleischman Michael S. Lawrence Lee Zou Rémi Buisson
author_facet	Pégah Jalili Danae Bowen Adam Langenbucher Shinho Park Kevin Aguirre Ryan B. Corcoran Angela G. Fleischman Michael S. Lawrence Lee Zou Rémi Buisson
author_sort	Pégah Jalili
title	Quantification of ongoing APOBEC3A activity in tumor cells by monitoring RNA editing at hotspots
title_short	Quantification of ongoing APOBEC3A activity in tumor cells by monitoring RNA editing at hotspots
title_full	Quantification of ongoing APOBEC3A activity in tumor cells by monitoring RNA editing at hotspots
title_fullStr	Quantification of ongoing APOBEC3A activity in tumor cells by monitoring RNA editing at hotspots
title_full_unstemmed	Quantification of ongoing APOBEC3A activity in tumor cells by monitoring RNA editing at hotspots
title_sort	quantification of ongoing apobec3a activity in tumor cells by monitoring rna editing at hotspots
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/ce56509c93e8439dabb97f9c99412c8c
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Quantification of ongoing APOBEC3A activity in tumor cells by monitoring RNA editing at hotspots

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