Examining brain white matter after pediatric mild traumatic brain injury using neurite orientation dispersion and density imaging: An A-CAP study

Background: Pediatric mild traumatic brain injury (mTBI) affects millions of children annually. Diffusion tensor imaging (DTI) is sensitive to axonal injuries and white matter microstructure and has been used to characterize the brain changes associated with mild traumatic brain injury (mTBI). Neuri...

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Autores principales:	Ayushi Shukla, Ashley L. Ware, Sunny Guo, Bradley Goodyear, Miriam H. Beauchamp, Roger Zemek, William Craig, Quynh Doan, Christian Beaulieu, Keith O. Yeates, Catherine Lebel
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Diffusion tensor imaging Neurite orientation dispersion and density imaging pediatric mTBI Mild orthopedic injury Computer applications to medicine. Medical informatics R858-859.7 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/ce5710748b7743688fff2df9d18a0294
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spelling	oai:doaj.org-article:ce5710748b7743688fff2df9d18a02942021-11-26T04:28:50ZExamining brain white matter after pediatric mild traumatic brain injury using neurite orientation dispersion and density imaging: An A-CAP study2213-158210.1016/j.nicl.2021.102887https://doaj.org/article/ce5710748b7743688fff2df9d18a02942021-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2213158221003314https://doaj.org/toc/2213-1582Background: Pediatric mild traumatic brain injury (mTBI) affects millions of children annually. Diffusion tensor imaging (DTI) is sensitive to axonal injuries and white matter microstructure and has been used to characterize the brain changes associated with mild traumatic brain injury (mTBI). Neurite orientation dispersion and density imaging (NODDI) is a diffusion model that can provide additional insight beyond traditional DTI metrics, but has not been examined in pediatric mTBI. The goal of this study was to employ DTI and NODDI to gain added insight into white matter alterations in children with mTBI compared to children with mild orthopedic injury (OI). Methods: Children (mTBI n = 320, OI n = 176) aged 8–16.99 years (12.39 ± 2.32 years) were recruited from emergency departments at five hospitals across Canada and underwent 3 T MRI on average 11 days post-injury. DTI and NODDI metrics were calculated for seven major white matter tracts and compared between groups using univariate analysis of covariance controlling for age, sex, and scanner type. False discovery rate (FDR) was used to correct for multiple comparisons. Results: Univariate analysis revealed no significant group main effects or interactions in DTI or NODDI metrics. Fractional anisotropy and neurite density index in all tracts exhibited a significant positive association with age and mean diffusivity in all tracts exhibited a significant negative association with age in the whole sample. Conclusions: Overall, there were no significant differences between mTBI and OI groups in brain white matter microstructure from either DTI or NODDI in the seven tracts. This indicates that mTBI is associated with relatively minor white matter differences, if any, at the post-acute stage. Brain differences may evolve at later stages of injury, so longitudinal studies with long-term follow-up are needed.Ayushi ShuklaAshley L. WareSunny GuoBradley GoodyearMiriam H. BeauchampRoger ZemekWilliam CraigQuynh DoanChristian BeaulieuKeith O. YeatesCatherine LebelElsevierarticleDiffusion tensor imagingNeurite orientation dispersion and density imagingpediatric mTBIMild orthopedic injuryComputer applications to medicine. Medical informaticsR858-859.7Neurology. Diseases of the nervous systemRC346-429ENNeuroImage: Clinical, Vol 32, Iss , Pp 102887- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diffusion tensor imaging Neurite orientation dispersion and density imaging pediatric mTBI Mild orthopedic injury Computer applications to medicine. Medical informatics R858-859.7 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Diffusion tensor imaging Neurite orientation dispersion and density imaging pediatric mTBI Mild orthopedic injury Computer applications to medicine. Medical informatics R858-859.7 Neurology. Diseases of the nervous system RC346-429 Ayushi Shukla Ashley L. Ware Sunny Guo Bradley Goodyear Miriam H. Beauchamp Roger Zemek William Craig Quynh Doan Christian Beaulieu Keith O. Yeates Catherine Lebel Examining brain white matter after pediatric mild traumatic brain injury using neurite orientation dispersion and density imaging: An A-CAP study
description	Background: Pediatric mild traumatic brain injury (mTBI) affects millions of children annually. Diffusion tensor imaging (DTI) is sensitive to axonal injuries and white matter microstructure and has been used to characterize the brain changes associated with mild traumatic brain injury (mTBI). Neurite orientation dispersion and density imaging (NODDI) is a diffusion model that can provide additional insight beyond traditional DTI metrics, but has not been examined in pediatric mTBI. The goal of this study was to employ DTI and NODDI to gain added insight into white matter alterations in children with mTBI compared to children with mild orthopedic injury (OI). Methods: Children (mTBI n = 320, OI n = 176) aged 8–16.99 years (12.39 ± 2.32 years) were recruited from emergency departments at five hospitals across Canada and underwent 3 T MRI on average 11 days post-injury. DTI and NODDI metrics were calculated for seven major white matter tracts and compared between groups using univariate analysis of covariance controlling for age, sex, and scanner type. False discovery rate (FDR) was used to correct for multiple comparisons. Results: Univariate analysis revealed no significant group main effects or interactions in DTI or NODDI metrics. Fractional anisotropy and neurite density index in all tracts exhibited a significant positive association with age and mean diffusivity in all tracts exhibited a significant negative association with age in the whole sample. Conclusions: Overall, there were no significant differences between mTBI and OI groups in brain white matter microstructure from either DTI or NODDI in the seven tracts. This indicates that mTBI is associated with relatively minor white matter differences, if any, at the post-acute stage. Brain differences may evolve at later stages of injury, so longitudinal studies with long-term follow-up are needed.
format	article
author	Ayushi Shukla Ashley L. Ware Sunny Guo Bradley Goodyear Miriam H. Beauchamp Roger Zemek William Craig Quynh Doan Christian Beaulieu Keith O. Yeates Catherine Lebel
author_facet	Ayushi Shukla Ashley L. Ware Sunny Guo Bradley Goodyear Miriam H. Beauchamp Roger Zemek William Craig Quynh Doan Christian Beaulieu Keith O. Yeates Catherine Lebel
author_sort	Ayushi Shukla
title	Examining brain white matter after pediatric mild traumatic brain injury using neurite orientation dispersion and density imaging: An A-CAP study
title_short	Examining brain white matter after pediatric mild traumatic brain injury using neurite orientation dispersion and density imaging: An A-CAP study
title_full	Examining brain white matter after pediatric mild traumatic brain injury using neurite orientation dispersion and density imaging: An A-CAP study
title_fullStr	Examining brain white matter after pediatric mild traumatic brain injury using neurite orientation dispersion and density imaging: An A-CAP study
title_full_unstemmed	Examining brain white matter after pediatric mild traumatic brain injury using neurite orientation dispersion and density imaging: An A-CAP study
title_sort	examining brain white matter after pediatric mild traumatic brain injury using neurite orientation dispersion and density imaging: an a-cap study
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/ce5710748b7743688fff2df9d18a0294
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Examining brain white matter after pediatric mild traumatic brain injury using neurite orientation dispersion and density imaging: An A-CAP study

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