Aryl hydrocarbon receptor is a prognostic biomarker and is correlated with immune responses in cervical cancer

Aryl hydrocarbon receptor (AHR) plays an important role in tumor development. However, its function in cervical cancer has not been fully elucidated. We evaluated the ten genes that are predicted to associate with AHR protein interaction. The comprehensive scores were: CYP1A1, ARNT2, HSP90AA1, ARNT,...

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Autores principales:	Jiasui Wang, Yilidana Mijiti, Yalin Chen, Zaoling Liu
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	ahr cervical cancer prognosis tumor-infiltrating bioinformatics Biotechnology TP248.13-248.65
Acceso en línea:	https://doaj.org/article/ce5c31a3ff584142891ab54bcf29e154
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spelling	oai:doaj.org-article:ce5c31a3ff584142891ab54bcf29e1542021-11-26T11:19:50ZAryl hydrocarbon receptor is a prognostic biomarker and is correlated with immune responses in cervical cancer2165-59792165-598710.1080/21655979.2021.2006953https://doaj.org/article/ce5c31a3ff584142891ab54bcf29e1542021-11-01T00:00:00Zhttp://dx.doi.org/10.1080/21655979.2021.2006953https://doaj.org/toc/2165-5979https://doaj.org/toc/2165-5987Aryl hydrocarbon receptor (AHR) plays an important role in tumor development. However, its function in cervical cancer has not been fully elucidated. We evaluated the ten genes that are predicted to associate with AHR protein interaction. The comprehensive scores were: CYP1A1, ARNT2, HSP90AA1, ARNT, AIP, PTGES3, HSP90AB1, CYP1B1, ESR1, MAF, respectively. In addition, we showed that levels of AHR and its related genes were correlated with the immune infiltration and expression of immuno-regulators (immunoinhibitors, immunostimulators, MHC molecules) levels in cervical cancer. High expression of AHR, CYP1A1, HSP90AA1, and HSP90AB1 and low expression of ESR1 were negatively correlated with the prognoses of cervical cancer patients. The Cox multivariate regression showed that high expression of AHR (HR=1.874, 95% CI=1.069- 3.285, P=0.028) and CYP1A1 (HR=1.822, 95 %CI=1.077- 3.080, P=0.025) were risk factors for prognosis in patients with cervical cancer. IHC results indicated that AHR and CYP1A1 were widely expressed in cervical cancer. These findings suggest that AHR and CYP1A1 may serve as prognostic biomarkers for determining prognosis and immune infiltration in cervical cancer.Jiasui WangYilidana MijitiYalin ChenZaoling LiuTaylor & Francis Grouparticleahrcervical cancerprognosistumor-infiltratingbioinformaticsBiotechnologyTP248.13-248.65ENBioengineered, Vol 0, Iss 0 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ahr cervical cancer prognosis tumor-infiltrating bioinformatics Biotechnology TP248.13-248.65
spellingShingle	ahr cervical cancer prognosis tumor-infiltrating bioinformatics Biotechnology TP248.13-248.65 Jiasui Wang Yilidana Mijiti Yalin Chen Zaoling Liu Aryl hydrocarbon receptor is a prognostic biomarker and is correlated with immune responses in cervical cancer
description	Aryl hydrocarbon receptor (AHR) plays an important role in tumor development. However, its function in cervical cancer has not been fully elucidated. We evaluated the ten genes that are predicted to associate with AHR protein interaction. The comprehensive scores were: CYP1A1, ARNT2, HSP90AA1, ARNT, AIP, PTGES3, HSP90AB1, CYP1B1, ESR1, MAF, respectively. In addition, we showed that levels of AHR and its related genes were correlated with the immune infiltration and expression of immuno-regulators (immunoinhibitors, immunostimulators, MHC molecules) levels in cervical cancer. High expression of AHR, CYP1A1, HSP90AA1, and HSP90AB1 and low expression of ESR1 were negatively correlated with the prognoses of cervical cancer patients. The Cox multivariate regression showed that high expression of AHR (HR=1.874, 95% CI=1.069- 3.285, P=0.028) and CYP1A1 (HR=1.822, 95 %CI=1.077- 3.080, P=0.025) were risk factors for prognosis in patients with cervical cancer. IHC results indicated that AHR and CYP1A1 were widely expressed in cervical cancer. These findings suggest that AHR and CYP1A1 may serve as prognostic biomarkers for determining prognosis and immune infiltration in cervical cancer.
format	article
author	Jiasui Wang Yilidana Mijiti Yalin Chen Zaoling Liu
author_facet	Jiasui Wang Yilidana Mijiti Yalin Chen Zaoling Liu
author_sort	Jiasui Wang
title	Aryl hydrocarbon receptor is a prognostic biomarker and is correlated with immune responses in cervical cancer
title_short	Aryl hydrocarbon receptor is a prognostic biomarker and is correlated with immune responses in cervical cancer
title_full	Aryl hydrocarbon receptor is a prognostic biomarker and is correlated with immune responses in cervical cancer
title_fullStr	Aryl hydrocarbon receptor is a prognostic biomarker and is correlated with immune responses in cervical cancer
title_full_unstemmed	Aryl hydrocarbon receptor is a prognostic biomarker and is correlated with immune responses in cervical cancer
title_sort	aryl hydrocarbon receptor is a prognostic biomarker and is correlated with immune responses in cervical cancer
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/ce5c31a3ff584142891ab54bcf29e154
work_keys_str_mv	AT jiasuiwang arylhydrocarbonreceptorisaprognosticbiomarkerandiscorrelatedwithimmuneresponsesincervicalcancer AT yilidanamijiti arylhydrocarbonreceptorisaprognosticbiomarkerandiscorrelatedwithimmuneresponsesincervicalcancer AT yalinchen arylhydrocarbonreceptorisaprognosticbiomarkerandiscorrelatedwithimmuneresponsesincervicalcancer AT zaolingliu arylhydrocarbonreceptorisaprognosticbiomarkerandiscorrelatedwithimmuneresponsesincervicalcancer
_version_	1718409500028829696

Aryl hydrocarbon receptor is a prognostic biomarker and is correlated with immune responses in cervical cancer

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