RUNX3 regulates cell cycle-dependent chromatin dynamics by functioning as a pioneer factor of the restriction-point

The transcription factor RUNX3 plays a key role in the restriction point of cell cycle. Here the authors showed that RUNX3 binds and opens chromatin structure of restriction point associated genes, by sequential recruitment of chromatin remodeling complex, transcription complex and cell cycle regula...

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Autores principales:	Jung-Won Lee, Da-Mi Kim, Ju-Won Jang, Tae-Geun Park, Soo-Hyun Song, You-Soub Lee, Xin-Zi Chi, Il Yeong Park, Jin-Won Hyun, Yoshiaki Ito, Suk-Chul Bae
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ce5cd98dd35b4a8b97f2416472079307
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spelling	oai:doaj.org-article:ce5cd98dd35b4a8b97f24164720793072021-12-02T17:01:38ZRUNX3 regulates cell cycle-dependent chromatin dynamics by functioning as a pioneer factor of the restriction-point10.1038/s41467-019-09810-w2041-1723https://doaj.org/article/ce5cd98dd35b4a8b97f24164720793072019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09810-whttps://doaj.org/toc/2041-1723The transcription factor RUNX3 plays a key role in the restriction point of cell cycle. Here the authors showed that RUNX3 binds and opens chromatin structure of restriction point associated genes, by sequential recruitment of chromatin remodeling complex, transcription complex and cell cycle regulators.Jung-Won LeeDa-Mi KimJu-Won JangTae-Geun ParkSoo-Hyun SongYou-Soub LeeXin-Zi ChiIl Yeong ParkJin-Won HyunYoshiaki ItoSuk-Chul BaeNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jung-Won Lee Da-Mi Kim Ju-Won Jang Tae-Geun Park Soo-Hyun Song You-Soub Lee Xin-Zi Chi Il Yeong Park Jin-Won Hyun Yoshiaki Ito Suk-Chul Bae RUNX3 regulates cell cycle-dependent chromatin dynamics by functioning as a pioneer factor of the restriction-point
description	The transcription factor RUNX3 plays a key role in the restriction point of cell cycle. Here the authors showed that RUNX3 binds and opens chromatin structure of restriction point associated genes, by sequential recruitment of chromatin remodeling complex, transcription complex and cell cycle regulators.
format	article
author	Jung-Won Lee Da-Mi Kim Ju-Won Jang Tae-Geun Park Soo-Hyun Song You-Soub Lee Xin-Zi Chi Il Yeong Park Jin-Won Hyun Yoshiaki Ito Suk-Chul Bae
author_facet	Jung-Won Lee Da-Mi Kim Ju-Won Jang Tae-Geun Park Soo-Hyun Song You-Soub Lee Xin-Zi Chi Il Yeong Park Jin-Won Hyun Yoshiaki Ito Suk-Chul Bae
author_sort	Jung-Won Lee
title	RUNX3 regulates cell cycle-dependent chromatin dynamics by functioning as a pioneer factor of the restriction-point
title_short	RUNX3 regulates cell cycle-dependent chromatin dynamics by functioning as a pioneer factor of the restriction-point
title_full	RUNX3 regulates cell cycle-dependent chromatin dynamics by functioning as a pioneer factor of the restriction-point
title_fullStr	RUNX3 regulates cell cycle-dependent chromatin dynamics by functioning as a pioneer factor of the restriction-point
title_full_unstemmed	RUNX3 regulates cell cycle-dependent chromatin dynamics by functioning as a pioneer factor of the restriction-point
title_sort	runx3 regulates cell cycle-dependent chromatin dynamics by functioning as a pioneer factor of the restriction-point
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/ce5cd98dd35b4a8b97f2416472079307
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RUNX3 regulates cell cycle-dependent chromatin dynamics by functioning as a pioneer factor of the restriction-point

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