A novel GPR119 agonist DA-1241 preserves pancreatic function via the suppression of ER stress and increased PDX1 expression

DA-1241 is a novel small molecule G protein-coupled receptor 119 (GPR119) agonist in early clinical development for type 2 diabetic patients. This study aimed to elucidate the pharmacological characteristics of DA-1241 for its hypoglycemic action. DA-1241 potently and selectively activated GPR119 wi...

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Auteurs principaux:	Mi-Kyung Kim, Ph.D, Ye Hwang Cheong, Ph.D, Seung Ho Lee, Ph.D, Tae Hyoung Kim, MS, Il Hoon Jung, MS, Yuna Chae, MS, Jeong-Ha Lee, MS, Eun Kyoung Yang, MS, Hansu Park, MS, Jae-Sung Yang, Ph.D, Ki Whan Hong, Ph.D
Format:	article
Langue:	EN
Publié:	Elsevier 2021
Sujets:	β-cell DA-1241 ER stress GPR119 agonist PDX1 Type 2 diabetes Therapeutics. Pharmacology RM1-950
Accès en ligne:	https://doaj.org/article/ce5e4a32e40c4c5c8f5e29692245201a
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A novel GPR119 agonist DA-1241 preserves pancreatic function via the suppression of ER stress and increased PDX1 expression

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