A novel GPR119 agonist DA-1241 preserves pancreatic function via the suppression of ER stress and increased PDX1 expression

A novel GPR119 agonist DA-1241 preserves pancreatic function via the suppression of ER stress and increased PDX1 expression

DA-1241 is a novel small molecule G protein-coupled receptor 119 (GPR119) agonist in early clinical development for type 2 diabetic patients. This study aimed to elucidate the pharmacological characteristics of DA-1241 for its hypoglycemic action. DA-1241 potently and selectively activated GPR119 wi...

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Main Authors: Mi-Kyung Kim, Ph.D, Ye Hwang Cheong, Ph.D, Seung Ho Lee, Ph.D, Tae Hyoung Kim, MS, Il Hoon Jung, MS, Yuna Chae, MS, Jeong-Ha Lee, MS, Eun Kyoung Yang, MS, Hansu Park, MS, Jae-Sung Yang, Ph.D, Ki Whan Hong, Ph.D
Format: article
Language:EN
Published: Elsevier 2021
Subjects:
β-cell
DA-1241
ER stress
GPR119 agonist
PDX1
Type 2 diabetes
Therapeutics. Pharmacology
RM1-950
Online Access:https://doaj.org/article/ce5e4a32e40c4c5c8f5e29692245201a
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https://doaj.org/article/ce5e4a32e40c4c5c8f5e29692245201a

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