Vps11 and Vps18 of Vps-C membrane traffic complexes are E3 ubiquitin ligases and fine-tune signalling

Endosomal fusion depends on the HOPS and CORVET complexes but whether and how their subunits modulate signal transduction is not fully understood. Here, the authors show that the HOPS/CORVET subunits Vps11 and Vps18 are E3 ubiquitin ligases that are involved in the regulation of ERα signalling.

Guardado en:

Detalles Bibliográficos
Autores principales:	Gregory Segala, Marcela A. Bennesch, Nastaran Mohammadi Ghahhari, Deo Prakash Pandey, Pablo C. Echeverria, François Karch, Robert K. Maeda, Didier Picard
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ce61553035444a5d9885729d73ae928a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ce61553035444a5d9885729d73ae928a
record_format	dspace
spelling	oai:doaj.org-article:ce61553035444a5d9885729d73ae928a2021-12-02T17:01:39ZVps11 and Vps18 of Vps-C membrane traffic complexes are E3 ubiquitin ligases and fine-tune signalling10.1038/s41467-019-09800-y2041-1723https://doaj.org/article/ce61553035444a5d9885729d73ae928a2019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09800-yhttps://doaj.org/toc/2041-1723Endosomal fusion depends on the HOPS and CORVET complexes but whether and how their subunits modulate signal transduction is not fully understood. Here, the authors show that the HOPS/CORVET subunits Vps11 and Vps18 are E3 ubiquitin ligases that are involved in the regulation of ERα signalling.Gregory SegalaMarcela A. BenneschNastaran Mohammadi GhahhariDeo Prakash PandeyPablo C. EcheverriaFrançois KarchRobert K. MaedaDidier PicardNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gregory Segala Marcela A. Bennesch Nastaran Mohammadi Ghahhari Deo Prakash Pandey Pablo C. Echeverria François Karch Robert K. Maeda Didier Picard Vps11 and Vps18 of Vps-C membrane traffic complexes are E3 ubiquitin ligases and fine-tune signalling
description	Endosomal fusion depends on the HOPS and CORVET complexes but whether and how their subunits modulate signal transduction is not fully understood. Here, the authors show that the HOPS/CORVET subunits Vps11 and Vps18 are E3 ubiquitin ligases that are involved in the regulation of ERα signalling.
format	article
author	Gregory Segala Marcela A. Bennesch Nastaran Mohammadi Ghahhari Deo Prakash Pandey Pablo C. Echeverria François Karch Robert K. Maeda Didier Picard
author_facet	Gregory Segala Marcela A. Bennesch Nastaran Mohammadi Ghahhari Deo Prakash Pandey Pablo C. Echeverria François Karch Robert K. Maeda Didier Picard
author_sort	Gregory Segala
title	Vps11 and Vps18 of Vps-C membrane traffic complexes are E3 ubiquitin ligases and fine-tune signalling
title_short	Vps11 and Vps18 of Vps-C membrane traffic complexes are E3 ubiquitin ligases and fine-tune signalling
title_full	Vps11 and Vps18 of Vps-C membrane traffic complexes are E3 ubiquitin ligases and fine-tune signalling
title_fullStr	Vps11 and Vps18 of Vps-C membrane traffic complexes are E3 ubiquitin ligases and fine-tune signalling
title_full_unstemmed	Vps11 and Vps18 of Vps-C membrane traffic complexes are E3 ubiquitin ligases and fine-tune signalling
title_sort	vps11 and vps18 of vps-c membrane traffic complexes are e3 ubiquitin ligases and fine-tune signalling
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/ce61553035444a5d9885729d73ae928a
work_keys_str_mv	AT gregorysegala vps11andvps18ofvpscmembranetrafficcomplexesaree3ubiquitinligasesandfinetunesignalling AT marcelaabennesch vps11andvps18ofvpscmembranetrafficcomplexesaree3ubiquitinligasesandfinetunesignalling AT nastaranmohammadighahhari vps11andvps18ofvpscmembranetrafficcomplexesaree3ubiquitinligasesandfinetunesignalling AT deoprakashpandey vps11andvps18ofvpscmembranetrafficcomplexesaree3ubiquitinligasesandfinetunesignalling AT pablocecheverria vps11andvps18ofvpscmembranetrafficcomplexesaree3ubiquitinligasesandfinetunesignalling AT francoiskarch vps11andvps18ofvpscmembranetrafficcomplexesaree3ubiquitinligasesandfinetunesignalling AT robertkmaeda vps11andvps18ofvpscmembranetrafficcomplexesaree3ubiquitinligasesandfinetunesignalling AT didierpicard vps11andvps18ofvpscmembranetrafficcomplexesaree3ubiquitinligasesandfinetunesignalling
_version_	1718382113512751104

Vps11 and Vps18 of Vps-C membrane traffic complexes are E3 ubiquitin ligases and fine-tune signalling

Ejemplares similares