The chloroalkaloid (−)-acutumine is biosynthesized via a Fe(II)- and 2-oxoglutarate-dependent halogenase in Menispermaceae plants

Halogenated plant natural products are rare and plant halogenation enzymes are thus far unknown. Here Kim et al. identify a dechloroacutumine halogenase from Common Moonseed that catalyzes the final chlorination step in the biosynthesis of acutumine, a chloroalkaloid with selective cytotoxicity to c...

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Autores principales:	Colin Y. Kim, Andrew J. Mitchell, Christopher M. Glinkerman, Fu-Shuang Li, Tomáš Pluskal, Jing-Ke Weng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ce648d60171844778ff00a7c3876dcf5
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spelling	oai:doaj.org-article:ce648d60171844778ff00a7c3876dcf52021-12-02T17:31:41ZThe chloroalkaloid (−)-acutumine is biosynthesized via a Fe(II)- and 2-oxoglutarate-dependent halogenase in Menispermaceae plants10.1038/s41467-020-15777-w2041-1723https://doaj.org/article/ce648d60171844778ff00a7c3876dcf52020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15777-whttps://doaj.org/toc/2041-1723Halogenated plant natural products are rare and plant halogenation enzymes are thus far unknown. Here Kim et al. identify a dechloroacutumine halogenase from Common Moonseed that catalyzes the final chlorination step in the biosynthesis of acutumine, a chloroalkaloid with selective cytotoxicity to cultured T cells.Colin Y. KimAndrew J. MitchellChristopher M. GlinkermanFu-Shuang LiTomáš PluskalJing-Ke WengNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-7 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Colin Y. Kim Andrew J. Mitchell Christopher M. Glinkerman Fu-Shuang Li Tomáš Pluskal Jing-Ke Weng The chloroalkaloid (−)-acutumine is biosynthesized via a Fe(II)- and 2-oxoglutarate-dependent halogenase in Menispermaceae plants
description	Halogenated plant natural products are rare and plant halogenation enzymes are thus far unknown. Here Kim et al. identify a dechloroacutumine halogenase from Common Moonseed that catalyzes the final chlorination step in the biosynthesis of acutumine, a chloroalkaloid with selective cytotoxicity to cultured T cells.
format	article
author	Colin Y. Kim Andrew J. Mitchell Christopher M. Glinkerman Fu-Shuang Li Tomáš Pluskal Jing-Ke Weng
author_facet	Colin Y. Kim Andrew J. Mitchell Christopher M. Glinkerman Fu-Shuang Li Tomáš Pluskal Jing-Ke Weng
author_sort	Colin Y. Kim
title	The chloroalkaloid (−)-acutumine is biosynthesized via a Fe(II)- and 2-oxoglutarate-dependent halogenase in Menispermaceae plants
title_short	The chloroalkaloid (−)-acutumine is biosynthesized via a Fe(II)- and 2-oxoglutarate-dependent halogenase in Menispermaceae plants
title_full	The chloroalkaloid (−)-acutumine is biosynthesized via a Fe(II)- and 2-oxoglutarate-dependent halogenase in Menispermaceae plants
title_fullStr	The chloroalkaloid (−)-acutumine is biosynthesized via a Fe(II)- and 2-oxoglutarate-dependent halogenase in Menispermaceae plants
title_full_unstemmed	The chloroalkaloid (−)-acutumine is biosynthesized via a Fe(II)- and 2-oxoglutarate-dependent halogenase in Menispermaceae plants
title_sort	chloroalkaloid (−)-acutumine is biosynthesized via a fe(ii)- and 2-oxoglutarate-dependent halogenase in menispermaceae plants
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/ce648d60171844778ff00a7c3876dcf5
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The chloroalkaloid (−)-acutumine is biosynthesized via a Fe(II)- and 2-oxoglutarate-dependent halogenase in Menispermaceae plants

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