The chloroalkaloid (−)-acutumine is biosynthesized via a Fe(II)- and 2-oxoglutarate-dependent halogenase in Menispermaceae plants

Halogenated plant natural products are rare and plant halogenation enzymes are thus far unknown. Here Kim et al. identify a dechloroacutumine halogenase from Common Moonseed that catalyzes the final chlorination step in the biosynthesis of acutumine, a chloroalkaloid with selective cytotoxicity to c...

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Auteurs principaux: Colin Y. Kim, Andrew J. Mitchell, Christopher M. Glinkerman, Fu-Shuang Li, Tomáš Pluskal, Jing-Ke Weng
Format: article
Langue:EN
Publié: Nature Portfolio 2020
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Accès en ligne:https://doaj.org/article/ce648d60171844778ff00a7c3876dcf5
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