LncRNA Snhg6 regulates the differentiation of MDSCs by regulating the ubiquitination of EZH2

Abstract Myeloid-derived suppressor cells (MDSCs) are derived from bone marrow progenitor cells commonly, which is a heterogeneous cell group composed of immature granulocytes, dendritic cells, macrophages and early undifferentiated bone marrow precursor cells. Its differentiation and immunosuppress...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Wei Lu, Fenghua Cao, Lili Feng, Ge Song, Yi Chang, Ying Chu, Zhihong Chen, Bo Shen, Huaxi Xu, Shengjun Wang, Jie Ma
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	MDSCs lncRNA Snhg6 EZH2 ubiquitination Differentiation Diseases of the blood and blood-forming organs RC633-647.5 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/ce6556fd10be46aeb25efea06cc32f65
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ce6556fd10be46aeb25efea06cc32f65
record_format	dspace
spelling	oai:doaj.org-article:ce6556fd10be46aeb25efea06cc32f652021-11-21T12:02:29ZLncRNA Snhg6 regulates the differentiation of MDSCs by regulating the ubiquitination of EZH210.1186/s13045-021-01212-01756-8722https://doaj.org/article/ce6556fd10be46aeb25efea06cc32f652021-11-01T00:00:00Zhttps://doi.org/10.1186/s13045-021-01212-0https://doaj.org/toc/1756-8722Abstract Myeloid-derived suppressor cells (MDSCs) are derived from bone marrow progenitor cells commonly, which is a heterogeneous cell group composed of immature granulocytes, dendritic cells, macrophages and early undifferentiated bone marrow precursor cells. Its differentiation and immunosuppressive function are regulated by complex network signals, but the specific regulation mechanisms are not yet fully understood. In this study, we found that in mouse of Lewis lung cancer xenograft, long non-coding RNA Snhg6 (lncRNA Snhg6) was highly expressed in tumor-derived MDSCs compared with spleen-derived MDSCs. LncRNA Snhg6 facilitated the differentiation of CD11b+ Ly6G− Ly6Chigh monocytic MDSCs (Mo-MDSCs) rather than CD11b+ Ly6G+ Ly6Clow polymorphonuclear MDSCs (PMN-MDSCs), but did not affect the immunosuppressive function of MDSCs. Notably, lncRNA Snhg6 could inhibit the expression of EZH2 by ubiquitination pathway at protein level rather than mRNA level during the differentiation of mouse bone marrow cells into MDSCs in vitro. EZH2 may be an important factor in the regulation of lncRNA Snhg6 to promote the differentiation of Mo-MDSCs. So what we found may provide new ideas and targets for anti-tumor immunotherapy targeting MDSCs.Wei LuFenghua CaoLili FengGe SongYi ChangYing ChuZhihong ChenBo ShenHuaxi XuShengjun WangJie MaBMCarticleMDSCslncRNA Snhg6EZH2ubiquitinationDifferentiationDiseases of the blood and blood-forming organsRC633-647.5Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENJournal of Hematology & Oncology, Vol 14, Iss 1, Pp 1-4 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	MDSCs lncRNA Snhg6 EZH2 ubiquitination Differentiation Diseases of the blood and blood-forming organs RC633-647.5 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	MDSCs lncRNA Snhg6 EZH2 ubiquitination Differentiation Diseases of the blood and blood-forming organs RC633-647.5 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Wei Lu Fenghua Cao Lili Feng Ge Song Yi Chang Ying Chu Zhihong Chen Bo Shen Huaxi Xu Shengjun Wang Jie Ma LncRNA Snhg6 regulates the differentiation of MDSCs by regulating the ubiquitination of EZH2
description	Abstract Myeloid-derived suppressor cells (MDSCs) are derived from bone marrow progenitor cells commonly, which is a heterogeneous cell group composed of immature granulocytes, dendritic cells, macrophages and early undifferentiated bone marrow precursor cells. Its differentiation and immunosuppressive function are regulated by complex network signals, but the specific regulation mechanisms are not yet fully understood. In this study, we found that in mouse of Lewis lung cancer xenograft, long non-coding RNA Snhg6 (lncRNA Snhg6) was highly expressed in tumor-derived MDSCs compared with spleen-derived MDSCs. LncRNA Snhg6 facilitated the differentiation of CD11b+ Ly6G− Ly6Chigh monocytic MDSCs (Mo-MDSCs) rather than CD11b+ Ly6G+ Ly6Clow polymorphonuclear MDSCs (PMN-MDSCs), but did not affect the immunosuppressive function of MDSCs. Notably, lncRNA Snhg6 could inhibit the expression of EZH2 by ubiquitination pathway at protein level rather than mRNA level during the differentiation of mouse bone marrow cells into MDSCs in vitro. EZH2 may be an important factor in the regulation of lncRNA Snhg6 to promote the differentiation of Mo-MDSCs. So what we found may provide new ideas and targets for anti-tumor immunotherapy targeting MDSCs.
format	article
author	Wei Lu Fenghua Cao Lili Feng Ge Song Yi Chang Ying Chu Zhihong Chen Bo Shen Huaxi Xu Shengjun Wang Jie Ma
author_facet	Wei Lu Fenghua Cao Lili Feng Ge Song Yi Chang Ying Chu Zhihong Chen Bo Shen Huaxi Xu Shengjun Wang Jie Ma
author_sort	Wei Lu
title	LncRNA Snhg6 regulates the differentiation of MDSCs by regulating the ubiquitination of EZH2
title_short	LncRNA Snhg6 regulates the differentiation of MDSCs by regulating the ubiquitination of EZH2
title_full	LncRNA Snhg6 regulates the differentiation of MDSCs by regulating the ubiquitination of EZH2
title_fullStr	LncRNA Snhg6 regulates the differentiation of MDSCs by regulating the ubiquitination of EZH2
title_full_unstemmed	LncRNA Snhg6 regulates the differentiation of MDSCs by regulating the ubiquitination of EZH2
title_sort	lncrna snhg6 regulates the differentiation of mdscs by regulating the ubiquitination of ezh2
publisher	BMC
publishDate	2021
url	https://doaj.org/article/ce6556fd10be46aeb25efea06cc32f65
work_keys_str_mv	AT weilu lncrnasnhg6regulatesthedifferentiationofmdscsbyregulatingtheubiquitinationofezh2 AT fenghuacao lncrnasnhg6regulatesthedifferentiationofmdscsbyregulatingtheubiquitinationofezh2 AT lilifeng lncrnasnhg6regulatesthedifferentiationofmdscsbyregulatingtheubiquitinationofezh2 AT gesong lncrnasnhg6regulatesthedifferentiationofmdscsbyregulatingtheubiquitinationofezh2 AT yichang lncrnasnhg6regulatesthedifferentiationofmdscsbyregulatingtheubiquitinationofezh2 AT yingchu lncrnasnhg6regulatesthedifferentiationofmdscsbyregulatingtheubiquitinationofezh2 AT zhihongchen lncrnasnhg6regulatesthedifferentiationofmdscsbyregulatingtheubiquitinationofezh2 AT boshen lncrnasnhg6regulatesthedifferentiationofmdscsbyregulatingtheubiquitinationofezh2 AT huaxixu lncrnasnhg6regulatesthedifferentiationofmdscsbyregulatingtheubiquitinationofezh2 AT shengjunwang lncrnasnhg6regulatesthedifferentiationofmdscsbyregulatingtheubiquitinationofezh2 AT jiema lncrnasnhg6regulatesthedifferentiationofmdscsbyregulatingtheubiquitinationofezh2
_version_	1718419331487891456

LncRNA Snhg6 regulates the differentiation of MDSCs by regulating the ubiquitination of EZH2

Ejemplares similares