Severe hindrance of viral infection propagation in spatially extended hosts.

The production of large progeny numbers affected by high mutation rates is a ubiquitous strategy of viruses, as it promotes quick adaptation and survival to changing environments. However, this situation often ushers in an arms race between the virus and the host cells. In this paper we investigate...

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Autores principales:	José A Capitán, José A Cuesta, Susanna C Manrubia, Jacobo Aguirre
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ce66cf5948d5479b89bd41e63d998016
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spelling	oai:doaj.org-article:ce66cf5948d5479b89bd41e63d9980162021-11-18T06:47:26ZSevere hindrance of viral infection propagation in spatially extended hosts.1932-620310.1371/journal.pone.0023358https://doaj.org/article/ce66cf5948d5479b89bd41e63d9980162011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21912595/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203The production of large progeny numbers affected by high mutation rates is a ubiquitous strategy of viruses, as it promotes quick adaptation and survival to changing environments. However, this situation often ushers in an arms race between the virus and the host cells. In this paper we investigate in depth a model for the dynamics of a phenotypically heterogeneous population of viruses whose propagation is limited to two-dimensional geometries, and where host cells are able to develop defenses against infection. Our analytical and numerical analyses are developed in close connection to directed percolation models. In fact, we show that making the space explicit in the model, which in turn amounts to reducing viral mobility and hindering the infective ability of the virus, connects our work with similar dynamical models that lie in the universality class of directed percolation. In addition, we use the fact that our model is a multicomponent generalization of the Domany-Kinzel probabilistic cellular automaton to employ several techniques developed in the past in that context, such as the two-site approximation to the extinction transition line. Our aim is to better understand propagation of viral infections with mobility restrictions, e.g., in crops or in plant leaves, in order to inspire new strategies for effective viral control.José A CapitánJosé A CuestaSusanna C ManrubiaJacobo AguirrePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 8, p e23358 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q José A Capitán José A Cuesta Susanna C Manrubia Jacobo Aguirre Severe hindrance of viral infection propagation in spatially extended hosts.
description	The production of large progeny numbers affected by high mutation rates is a ubiquitous strategy of viruses, as it promotes quick adaptation and survival to changing environments. However, this situation often ushers in an arms race between the virus and the host cells. In this paper we investigate in depth a model for the dynamics of a phenotypically heterogeneous population of viruses whose propagation is limited to two-dimensional geometries, and where host cells are able to develop defenses against infection. Our analytical and numerical analyses are developed in close connection to directed percolation models. In fact, we show that making the space explicit in the model, which in turn amounts to reducing viral mobility and hindering the infective ability of the virus, connects our work with similar dynamical models that lie in the universality class of directed percolation. In addition, we use the fact that our model is a multicomponent generalization of the Domany-Kinzel probabilistic cellular automaton to employ several techniques developed in the past in that context, such as the two-site approximation to the extinction transition line. Our aim is to better understand propagation of viral infections with mobility restrictions, e.g., in crops or in plant leaves, in order to inspire new strategies for effective viral control.
format	article
author	José A Capitán José A Cuesta Susanna C Manrubia Jacobo Aguirre
author_facet	José A Capitán José A Cuesta Susanna C Manrubia Jacobo Aguirre
author_sort	José A Capitán
title	Severe hindrance of viral infection propagation in spatially extended hosts.
title_short	Severe hindrance of viral infection propagation in spatially extended hosts.
title_full	Severe hindrance of viral infection propagation in spatially extended hosts.
title_fullStr	Severe hindrance of viral infection propagation in spatially extended hosts.
title_full_unstemmed	Severe hindrance of viral infection propagation in spatially extended hosts.
title_sort	severe hindrance of viral infection propagation in spatially extended hosts.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/ce66cf5948d5479b89bd41e63d998016
work_keys_str_mv	AT joseacapitan severehindranceofviralinfectionpropagationinspatiallyextendedhosts AT joseacuesta severehindranceofviralinfectionpropagationinspatiallyextendedhosts AT susannacmanrubia severehindranceofviralinfectionpropagationinspatiallyextendedhosts AT jacoboaguirre severehindranceofviralinfectionpropagationinspatiallyextendedhosts
_version_	1718424446443716608

Severe hindrance of viral infection propagation in spatially extended hosts.

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