DMRT1-mediated reprogramming drives development of cancer resembling human germ cell tumors with features of totipotency

DMRT1-mediated reprogramming drives development of cancer resembling human germ cell tumors with features of totipotency

The mechanisms by which in vivo expression of the Yamanaka transcription factors (OSKM) renders somatic cells permissive for differentiation remain unclear. Here, the authors show that in vivo reprogramming using OSKM generates germ cell tumors and drives acquisition of totipotency-like features in...

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Autores principales: Jumpei Taguchi, Hirofumi Shibata, Mio Kabata, Masaki Kato, Kei Fukuda, Akito Tanaka, Sho Ohta, Tomoyo Ukai, Kanae Mitsunaga, Yosuke Yamada, So I Nagaoka, Sho Yamazawa, Kotaro Ohnishi, Knut Woltjen, Tetsuo Ushiku, Manabu Ozawa, Mitinori Saitou, Yoichi Shinkai, Takuya Yamamoto, Yasuhiro Yamada
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Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/ce67fa07507345ab98bca02b31126aed
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spelling oai:doaj.org-article:ce67fa07507345ab98bca02b31126aed2021-12-02T17:08:39ZDMRT1-mediated reprogramming drives development of cancer resembling human germ cell tumors with features of totipotency10.1038/s41467-021-25249-42041-1723https://doaj.org/article/ce67fa07507345ab98bca02b31126aed2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25249-4https://doaj.org/toc/2041-1723The mechanisms by which in vivo expression of the Yamanaka transcription factors (OSKM) renders somatic cells permissive for differentiation remain unclear. Here, the authors show that in vivo reprogramming using OSKM generates germ cell tumors and drives acquisition of totipotency-like features in somatic cells through DMRT1.Jumpei TaguchiHirofumi ShibataMio KabataMasaki KatoKei FukudaAkito TanakaSho OhtaTomoyo UkaiKanae MitsunagaYosuke YamadaSo I NagaokaSho YamazawaKotaro OhnishiKnut WoltjenTetsuo UshikuManabu OzawaMitinori SaitouYoichi ShinkaiTakuya YamamotoYasuhiro YamadaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Jumpei Taguchi
Hirofumi Shibata
Mio Kabata
Masaki Kato
Kei Fukuda
Akito Tanaka
Sho Ohta
Tomoyo Ukai
Kanae Mitsunaga
Yosuke Yamada
So I Nagaoka
Sho Yamazawa
Kotaro Ohnishi
Knut Woltjen
Tetsuo Ushiku
Manabu Ozawa
Mitinori Saitou
Yoichi Shinkai
Takuya Yamamoto
Yasuhiro Yamada
DMRT1-mediated reprogramming drives development of cancer resembling human germ cell tumors with features of totipotency
description The mechanisms by which in vivo expression of the Yamanaka transcription factors (OSKM) renders somatic cells permissive for differentiation remain unclear. Here, the authors show that in vivo reprogramming using OSKM generates germ cell tumors and drives acquisition of totipotency-like features in somatic cells through DMRT1.
format article
author Jumpei Taguchi
Hirofumi Shibata
Mio Kabata
Masaki Kato
Kei Fukuda
Akito Tanaka
Sho Ohta
Tomoyo Ukai
Kanae Mitsunaga
Yosuke Yamada
So I Nagaoka
Sho Yamazawa
Kotaro Ohnishi
Knut Woltjen
Tetsuo Ushiku
Manabu Ozawa
Mitinori Saitou
Yoichi Shinkai
Takuya Yamamoto
Yasuhiro Yamada
author_facet Jumpei Taguchi
Hirofumi Shibata
Mio Kabata
Masaki Kato
Kei Fukuda
Akito Tanaka
Sho Ohta
Tomoyo Ukai
Kanae Mitsunaga
Yosuke Yamada
So I Nagaoka
Sho Yamazawa
Kotaro Ohnishi
Knut Woltjen
Tetsuo Ushiku
Manabu Ozawa
Mitinori Saitou
Yoichi Shinkai
Takuya Yamamoto
Yasuhiro Yamada
author_sort Jumpei Taguchi
title DMRT1-mediated reprogramming drives development of cancer resembling human germ cell tumors with features of totipotency
title_short DMRT1-mediated reprogramming drives development of cancer resembling human germ cell tumors with features of totipotency
title_full DMRT1-mediated reprogramming drives development of cancer resembling human germ cell tumors with features of totipotency
title_fullStr DMRT1-mediated reprogramming drives development of cancer resembling human germ cell tumors with features of totipotency
title_full_unstemmed DMRT1-mediated reprogramming drives development of cancer resembling human germ cell tumors with features of totipotency
title_sort dmrt1-mediated reprogramming drives development of cancer resembling human germ cell tumors with features of totipotency
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/ce67fa07507345ab98bca02b31126aed
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