Quantitative dual-energy CT for evaluating hepatocellular carcinoma after transarterial chemoembolization

Abstract We aimed to investigate the role of the quantitative parameters of dual-energy computed tomography (DECT) in evaluating patients with hepatocellular carcinoma (HCC) treated by transarterial chemoembolization (TACE). We retrospectively identified 80 HCC patients (mean age, 56 years; 61 men)...

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Autores principales:	Xiaofei Yue, Qiqi Jiang, Xuehan Hu, Chunyuan Cen, Songlin Song, Kun Qian, Yuting Lu, Ming Yang, Qian Li, Ping Han
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ce6a8ac71e554774afe7e27b687d1f55
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spelling	oai:doaj.org-article:ce6a8ac71e554774afe7e27b687d1f552021-12-02T15:49:50ZQuantitative dual-energy CT for evaluating hepatocellular carcinoma after transarterial chemoembolization10.1038/s41598-021-90508-92045-2322https://doaj.org/article/ce6a8ac71e554774afe7e27b687d1f552021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90508-9https://doaj.org/toc/2045-2322Abstract We aimed to investigate the role of the quantitative parameters of dual-energy computed tomography (DECT) in evaluating patients with hepatocellular carcinoma (HCC) treated by transarterial chemoembolization (TACE). We retrospectively identified 80 HCC patients (mean age, 56 years; 61 men) treated by TACE who received contrast-enhanced DECT and were retreated by TACE within 7 days between November 2018 and December 2019. Taking digital subtraction angiography (DSA) and CT images as reference standard, two readers measured and calculated the values of normalized iodine concentration at arterial phase (NICAP), normalized iodine concentration at portal venous phase (NICPP), iodine concentration difference (ICD), arterial iodine fraction (AIF) and slope of the spectral Hounsfield unit curve (λHu) by placing matched regions of interests (ROIs) within the tumor active area (TAA), adjacent normal hepatic parenchyma (ANHP) and tumor necrotic area (TNA). Differences between the parameters were analyzed by the Kruskal–Wallis H test. Receiver operating characteristic analysis of the parameters performance in differentiating the three tissues types was performed. AIF exhibited a good performance in distinguishing TAA (0.93 ± 0.31) and ANHP (0.18 ± 0.14), the areas under the receiver operating characteristic curve (AUC) was 0.989, while the λHu exhibited an excellent performance in distinguishing TAA (3.32 ± 1.24) and TNA (0.29 ± 0.27), with an AUC of 1.000. In conclusion, quantitative DECT can be effectively used to evaluate the tumor viability in HCC patients treated by TACE.Xiaofei YueQiqi JiangXuehan HuChunyuan CenSonglin SongKun QianYuting LuMing YangQian LiPing HanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xiaofei Yue Qiqi Jiang Xuehan Hu Chunyuan Cen Songlin Song Kun Qian Yuting Lu Ming Yang Qian Li Ping Han Quantitative dual-energy CT for evaluating hepatocellular carcinoma after transarterial chemoembolization
description	Abstract We aimed to investigate the role of the quantitative parameters of dual-energy computed tomography (DECT) in evaluating patients with hepatocellular carcinoma (HCC) treated by transarterial chemoembolization (TACE). We retrospectively identified 80 HCC patients (mean age, 56 years; 61 men) treated by TACE who received contrast-enhanced DECT and were retreated by TACE within 7 days between November 2018 and December 2019. Taking digital subtraction angiography (DSA) and CT images as reference standard, two readers measured and calculated the values of normalized iodine concentration at arterial phase (NICAP), normalized iodine concentration at portal venous phase (NICPP), iodine concentration difference (ICD), arterial iodine fraction (AIF) and slope of the spectral Hounsfield unit curve (λHu) by placing matched regions of interests (ROIs) within the tumor active area (TAA), adjacent normal hepatic parenchyma (ANHP) and tumor necrotic area (TNA). Differences between the parameters were analyzed by the Kruskal–Wallis H test. Receiver operating characteristic analysis of the parameters performance in differentiating the three tissues types was performed. AIF exhibited a good performance in distinguishing TAA (0.93 ± 0.31) and ANHP (0.18 ± 0.14), the areas under the receiver operating characteristic curve (AUC) was 0.989, while the λHu exhibited an excellent performance in distinguishing TAA (3.32 ± 1.24) and TNA (0.29 ± 0.27), with an AUC of 1.000. In conclusion, quantitative DECT can be effectively used to evaluate the tumor viability in HCC patients treated by TACE.
format	article
author	Xiaofei Yue Qiqi Jiang Xuehan Hu Chunyuan Cen Songlin Song Kun Qian Yuting Lu Ming Yang Qian Li Ping Han
author_facet	Xiaofei Yue Qiqi Jiang Xuehan Hu Chunyuan Cen Songlin Song Kun Qian Yuting Lu Ming Yang Qian Li Ping Han
author_sort	Xiaofei Yue
title	Quantitative dual-energy CT for evaluating hepatocellular carcinoma after transarterial chemoembolization
title_short	Quantitative dual-energy CT for evaluating hepatocellular carcinoma after transarterial chemoembolization
title_full	Quantitative dual-energy CT for evaluating hepatocellular carcinoma after transarterial chemoembolization
title_fullStr	Quantitative dual-energy CT for evaluating hepatocellular carcinoma after transarterial chemoembolization
title_full_unstemmed	Quantitative dual-energy CT for evaluating hepatocellular carcinoma after transarterial chemoembolization
title_sort	quantitative dual-energy ct for evaluating hepatocellular carcinoma after transarterial chemoembolization
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ce6a8ac71e554774afe7e27b687d1f55
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Quantitative dual-energy CT for evaluating hepatocellular carcinoma after transarterial chemoembolization

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