The order and logic of CD4 versus CD8 lineage choice and differentiation in mouse thymus

The order and logic of CD4 versus CD8 lineage choice and differentiation in mouse thymus

Developing T cells commit to either CD4/helper or CD8/cytotoxic lineage in the thymus, but how CD4 and CD8 coreceptors and TCR signaling dictate this selection process is still unclear. Here the authors use single cell RNA sequencing of mouse thymocytes to show that, in selection intermediates, TCR...

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Autores principales: Mohammad M. Karimi, Ya Guo, Xiaokai Cui, Husayn A. Pallikonda, Veronika Horková, Yi-Fang Wang, Sara Ruiz Gil, Gustavo Rodriguez-Esteban, Irene Robles-Rebollo, Ludovica Bruno, Radina Georgieva, Bhavik Patel, James Elliott, Marian H. Dore, Danielle Dauphars, Michael S. Krangel, Boris Lenhard, Holger Heyn, Amanda G. Fisher, Ondřej Štěpánek, Matthias Merkenschlager
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Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/ce6d54e4a05749d99545339b720e286a
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spelling oai:doaj.org-article:ce6d54e4a05749d99545339b720e286a2021-12-02T15:07:59ZThe order and logic of CD4 versus CD8 lineage choice and differentiation in mouse thymus10.1038/s41467-020-20306-w2041-1723https://doaj.org/article/ce6d54e4a05749d99545339b720e286a2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20306-whttps://doaj.org/toc/2041-1723Developing T cells commit to either CD4/helper or CD8/cytotoxic lineage in the thymus, but how CD4 and CD8 coreceptors and TCR signaling dictate this selection process is still unclear. Here the authors use single cell RNA sequencing of mouse thymocytes to show that, in selection intermediates, TCR signaling strength informs coreceptor expression timing.Mohammad M. KarimiYa GuoXiaokai CuiHusayn A. PallikondaVeronika HorkováYi-Fang WangSara Ruiz GilGustavo Rodriguez-EstebanIrene Robles-RebolloLudovica BrunoRadina GeorgievaBhavik PatelJames ElliottMarian H. DoreDanielle DaupharsMichael S. KrangelBoris LenhardHolger HeynAmanda G. FisherOndřej ŠtěpánekMatthias MerkenschlagerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Mohammad M. Karimi
Ya Guo
Xiaokai Cui
Husayn A. Pallikonda
Veronika Horková
Yi-Fang Wang
Sara Ruiz Gil
Gustavo Rodriguez-Esteban
Irene Robles-Rebollo
Ludovica Bruno
Radina Georgieva
Bhavik Patel
James Elliott
Marian H. Dore
Danielle Dauphars
Michael S. Krangel
Boris Lenhard
Holger Heyn
Amanda G. Fisher
Ondřej Štěpánek
Matthias Merkenschlager
The order and logic of CD4 versus CD8 lineage choice and differentiation in mouse thymus
description Developing T cells commit to either CD4/helper or CD8/cytotoxic lineage in the thymus, but how CD4 and CD8 coreceptors and TCR signaling dictate this selection process is still unclear. Here the authors use single cell RNA sequencing of mouse thymocytes to show that, in selection intermediates, TCR signaling strength informs coreceptor expression timing.
format article
author Mohammad M. Karimi
Ya Guo
Xiaokai Cui
Husayn A. Pallikonda
Veronika Horková
Yi-Fang Wang
Sara Ruiz Gil
Gustavo Rodriguez-Esteban
Irene Robles-Rebollo
Ludovica Bruno
Radina Georgieva
Bhavik Patel
James Elliott
Marian H. Dore
Danielle Dauphars
Michael S. Krangel
Boris Lenhard
Holger Heyn
Amanda G. Fisher
Ondřej Štěpánek
Matthias Merkenschlager
author_facet Mohammad M. Karimi
Ya Guo
Xiaokai Cui
Husayn A. Pallikonda
Veronika Horková
Yi-Fang Wang
Sara Ruiz Gil
Gustavo Rodriguez-Esteban
Irene Robles-Rebollo
Ludovica Bruno
Radina Georgieva
Bhavik Patel
James Elliott
Marian H. Dore
Danielle Dauphars
Michael S. Krangel
Boris Lenhard
Holger Heyn
Amanda G. Fisher
Ondřej Štěpánek
Matthias Merkenschlager
author_sort Mohammad M. Karimi
title The order and logic of CD4 versus CD8 lineage choice and differentiation in mouse thymus
title_short The order and logic of CD4 versus CD8 lineage choice and differentiation in mouse thymus
title_full The order and logic of CD4 versus CD8 lineage choice and differentiation in mouse thymus
title_fullStr The order and logic of CD4 versus CD8 lineage choice and differentiation in mouse thymus
title_full_unstemmed The order and logic of CD4 versus CD8 lineage choice and differentiation in mouse thymus
title_sort order and logic of cd4 versus cd8 lineage choice and differentiation in mouse thymus
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/ce6d54e4a05749d99545339b720e286a
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