The role of abnormalities of lipoproteins and HDL functionality in small fibre dysfunction in people with severe obesity

Abstract Obesity and associated dyslipidemia may contribute to increased cardiovascular disease. Obesity has also been associated with neuropathy. We have investigated presence of peripheral nerve damage in patients with severe obesity without type 2 diabetes and the status of metabolic syndrome and...

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Autores principales:	Shazli Azmi, Maryam Ferdousi, Yifen Liu, Safwaan Adam, Tarza Siahmansur, Georgios Ponirakis, Andrew Marshall, Ioannis N. Petropoulos, Jan Hoong Ho, Akheel A. Syed, John M. Gibson, Basil J. Ammori, Paul N. Durrington, Rayaz A. Malik, Handrean Soran
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ce6f7d4ff81f434ea4ea3b62b86da46e
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spelling	oai:doaj.org-article:ce6f7d4ff81f434ea4ea3b62b86da46e2021-12-02T17:23:49ZThe role of abnormalities of lipoproteins and HDL functionality in small fibre dysfunction in people with severe obesity10.1038/s41598-021-90346-92045-2322https://doaj.org/article/ce6f7d4ff81f434ea4ea3b62b86da46e2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90346-9https://doaj.org/toc/2045-2322Abstract Obesity and associated dyslipidemia may contribute to increased cardiovascular disease. Obesity has also been associated with neuropathy. We have investigated presence of peripheral nerve damage in patients with severe obesity without type 2 diabetes and the status of metabolic syndrome and lipoprotein abnormalities. 47participants with severe obesity and 30 age-matched healthy controls underwent detailed phenotyping of neuropathy and an assessment of lipoproteins and HDL-functionality. Participants with severe obesity had a higher neuropathy symptom profile, lower sural and peroneal nerve amplitudes, abnormal thermal thresholds, heart rate variability with deep breathing and corneal nerve parameters compared to healthy controls. Circulating apolipoprotein A1 (P = 0.009), HDL cholesterol (HDL-C) (P < 0.0001), cholesterol efflux (P = 0.002) and paroxonase-1 (PON-1) activity (P < 0.0001) were lower, and serum amyloid A (SAA) (P < 0.0001) was higher in participants with obesity compared to controls. Obese participants with small nerve fibre damage had higher serum triglycerides (P = 0.02), lower PON-1 activity (P = 0.002) and higher prevalence of metabolic syndrome (58% vs. 23%, P = 0.02) compared to those without. However, HDL-C (P = 0.8), cholesterol efflux (P = 0.08), apoA1 (P = 0.8) and SAA (P = 0.8) did not differ significantly between obese participants with and without small nerve fibre damage. Small nerve fibre damage occurs in people with severe obesity. Patients with obesity have deranged lipoproteins and compromised HDL functionality compared to controls. Obese patients with evidence of small nerve fibre damage, compared to those without, had significantly higher serum triglycerides, lower PON-1 activity and a higher prevalence of metabolic syndrome.Shazli AzmiMaryam FerdousiYifen LiuSafwaan AdamTarza SiahmansurGeorgios PonirakisAndrew MarshallIoannis N. PetropoulosJan Hoong HoAkheel A. SyedJohn M. GibsonBasil J. AmmoriPaul N. DurringtonRayaz A. MalikHandrean SoranNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shazli Azmi Maryam Ferdousi Yifen Liu Safwaan Adam Tarza Siahmansur Georgios Ponirakis Andrew Marshall Ioannis N. Petropoulos Jan Hoong Ho Akheel A. Syed John M. Gibson Basil J. Ammori Paul N. Durrington Rayaz A. Malik Handrean Soran The role of abnormalities of lipoproteins and HDL functionality in small fibre dysfunction in people with severe obesity
description	Abstract Obesity and associated dyslipidemia may contribute to increased cardiovascular disease. Obesity has also been associated with neuropathy. We have investigated presence of peripheral nerve damage in patients with severe obesity without type 2 diabetes and the status of metabolic syndrome and lipoprotein abnormalities. 47participants with severe obesity and 30 age-matched healthy controls underwent detailed phenotyping of neuropathy and an assessment of lipoproteins and HDL-functionality. Participants with severe obesity had a higher neuropathy symptom profile, lower sural and peroneal nerve amplitudes, abnormal thermal thresholds, heart rate variability with deep breathing and corneal nerve parameters compared to healthy controls. Circulating apolipoprotein A1 (P = 0.009), HDL cholesterol (HDL-C) (P < 0.0001), cholesterol efflux (P = 0.002) and paroxonase-1 (PON-1) activity (P < 0.0001) were lower, and serum amyloid A (SAA) (P < 0.0001) was higher in participants with obesity compared to controls. Obese participants with small nerve fibre damage had higher serum triglycerides (P = 0.02), lower PON-1 activity (P = 0.002) and higher prevalence of metabolic syndrome (58% vs. 23%, P = 0.02) compared to those without. However, HDL-C (P = 0.8), cholesterol efflux (P = 0.08), apoA1 (P = 0.8) and SAA (P = 0.8) did not differ significantly between obese participants with and without small nerve fibre damage. Small nerve fibre damage occurs in people with severe obesity. Patients with obesity have deranged lipoproteins and compromised HDL functionality compared to controls. Obese patients with evidence of small nerve fibre damage, compared to those without, had significantly higher serum triglycerides, lower PON-1 activity and a higher prevalence of metabolic syndrome.
format	article
author	Shazli Azmi Maryam Ferdousi Yifen Liu Safwaan Adam Tarza Siahmansur Georgios Ponirakis Andrew Marshall Ioannis N. Petropoulos Jan Hoong Ho Akheel A. Syed John M. Gibson Basil J. Ammori Paul N. Durrington Rayaz A. Malik Handrean Soran
author_facet	Shazli Azmi Maryam Ferdousi Yifen Liu Safwaan Adam Tarza Siahmansur Georgios Ponirakis Andrew Marshall Ioannis N. Petropoulos Jan Hoong Ho Akheel A. Syed John M. Gibson Basil J. Ammori Paul N. Durrington Rayaz A. Malik Handrean Soran
author_sort	Shazli Azmi
title	The role of abnormalities of lipoproteins and HDL functionality in small fibre dysfunction in people with severe obesity
title_short	The role of abnormalities of lipoproteins and HDL functionality in small fibre dysfunction in people with severe obesity
title_full	The role of abnormalities of lipoproteins and HDL functionality in small fibre dysfunction in people with severe obesity
title_fullStr	The role of abnormalities of lipoproteins and HDL functionality in small fibre dysfunction in people with severe obesity
title_full_unstemmed	The role of abnormalities of lipoproteins and HDL functionality in small fibre dysfunction in people with severe obesity
title_sort	role of abnormalities of lipoproteins and hdl functionality in small fibre dysfunction in people with severe obesity
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ce6f7d4ff81f434ea4ea3b62b86da46e
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The role of abnormalities of lipoproteins and HDL functionality in small fibre dysfunction in people with severe obesity

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