Stability and folding pathways of tetra-nucleosome from six-dimensional free energy surface

The three-dimensional organization of chromatin plays critical roles in regulating genome function. Here the authors apply a near atomistic model to study the structure and dynamics of the chromatin folding unit - the tetra-nucleosome - to provide insight into how chromatin folds.

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Autores principales: Xinqiang Ding, Xingcheng Lin, Bin Zhang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/ce70e2bc0c774c9db71e82b9808904b7
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spelling oai:doaj.org-article:ce70e2bc0c774c9db71e82b9808904b72021-12-02T12:11:11ZStability and folding pathways of tetra-nucleosome from six-dimensional free energy surface10.1038/s41467-021-21377-z2041-1723https://doaj.org/article/ce70e2bc0c774c9db71e82b9808904b72021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21377-zhttps://doaj.org/toc/2041-1723The three-dimensional organization of chromatin plays critical roles in regulating genome function. Here the authors apply a near atomistic model to study the structure and dynamics of the chromatin folding unit - the tetra-nucleosome - to provide insight into how chromatin folds.Xinqiang DingXingcheng LinBin ZhangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Xinqiang Ding
Xingcheng Lin
Bin Zhang
Stability and folding pathways of tetra-nucleosome from six-dimensional free energy surface
description The three-dimensional organization of chromatin plays critical roles in regulating genome function. Here the authors apply a near atomistic model to study the structure and dynamics of the chromatin folding unit - the tetra-nucleosome - to provide insight into how chromatin folds.
format article
author Xinqiang Ding
Xingcheng Lin
Bin Zhang
author_facet Xinqiang Ding
Xingcheng Lin
Bin Zhang
author_sort Xinqiang Ding
title Stability and folding pathways of tetra-nucleosome from six-dimensional free energy surface
title_short Stability and folding pathways of tetra-nucleosome from six-dimensional free energy surface
title_full Stability and folding pathways of tetra-nucleosome from six-dimensional free energy surface
title_fullStr Stability and folding pathways of tetra-nucleosome from six-dimensional free energy surface
title_full_unstemmed Stability and folding pathways of tetra-nucleosome from six-dimensional free energy surface
title_sort stability and folding pathways of tetra-nucleosome from six-dimensional free energy surface
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/ce70e2bc0c774c9db71e82b9808904b7
work_keys_str_mv AT xinqiangding stabilityandfoldingpathwaysoftetranucleosomefromsixdimensionalfreeenergysurface
AT xingchenglin stabilityandfoldingpathwaysoftetranucleosomefromsixdimensionalfreeenergysurface
AT binzhang stabilityandfoldingpathwaysoftetranucleosomefromsixdimensionalfreeenergysurface
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