Monosodium glutamate (MSG) consumption is associated with urolithiasis and urinary tract obstruction in rats.

<h4>Background</h4>The peritoneal injection of monosodium glutamate (MSG) can induce kidney injury in adult rats but the effects of long-term oral intake have not been determined.<h4>Methods</h4>We investigated the kidney histology and function in adult male Wistar rats that...

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Autores principales:	Amod Sharma, Vitoon Prasongwattana, Ubon Cha'on, Carlo Selmi, Wiphawi Hipkaeo, Piyanard Boonnate, Supattra Pethlert, Tanin Titipungul, Piyapharom Intarawichian, Sakda Waraasawapati, Anucha Puapiroj, Visith Sitprija, Sirirat Reungjui
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ce71ca69ce9645f984ff8a53df5d42ce
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spelling	oai:doaj.org-article:ce71ca69ce9645f984ff8a53df5d42ce2021-11-18T08:53:36ZMonosodium glutamate (MSG) consumption is associated with urolithiasis and urinary tract obstruction in rats.1932-620310.1371/journal.pone.0075546https://doaj.org/article/ce71ca69ce9645f984ff8a53df5d42ce2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24086562/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>The peritoneal injection of monosodium glutamate (MSG) can induce kidney injury in adult rats but the effects of long-term oral intake have not been determined.<h4>Methods</h4>We investigated the kidney histology and function in adult male Wistar rats that were fed ad libitum with a standard rat chow pellet and water with or without the addition of 2 mg/g body weight MSG/day in drinking water (n=10 per group). Both MSG-treated and control animals were sacrificed after 9 months when renal function parameters, blood and urine electrolytes, and tissue histopathology were determined.<h4>Results</h4>MSG-treated rats were more prone to kidney stone formation, as represented by the alkaline urine and significantly higher activity product of calcium phosphate. Accordingly, 3/10 MSG-treated rats developed kidney stones over 9 months versus none of the control animals. Further, 2/10 MSG-treated rats but none (0/10) of the controls manifested hydronephrosis. MSG-treated rats had significantly higher levels of serum creatinine and potassium including urine output volume, urinary excretion sodium and citrate compared to controls. In contrast, MSG-treated rats had significantly lower ammonium and magnesium urinary excretion.<h4>Conclusion</h4>Oral MSG consumption appears to cause alkaline urine and may increase the risks of kidney stones with hydronephrosis in rats. Similar effects in humans must be verified by dedicated studies.Amod SharmaVitoon PrasongwattanaUbon Cha'onCarlo SelmiWiphawi HipkaeoPiyanard BoonnateSupattra PethlertTanin TitipungulPiyapharom IntarawichianSakda WaraasawapatiAnucha PuapirojVisith SitprijaSirirat ReungjuiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 9, p e75546 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Amod Sharma Vitoon Prasongwattana Ubon Cha'on Carlo Selmi Wiphawi Hipkaeo Piyanard Boonnate Supattra Pethlert Tanin Titipungul Piyapharom Intarawichian Sakda Waraasawapati Anucha Puapiroj Visith Sitprija Sirirat Reungjui Monosodium glutamate (MSG) consumption is associated with urolithiasis and urinary tract obstruction in rats.
description	<h4>Background</h4>The peritoneal injection of monosodium glutamate (MSG) can induce kidney injury in adult rats but the effects of long-term oral intake have not been determined.<h4>Methods</h4>We investigated the kidney histology and function in adult male Wistar rats that were fed ad libitum with a standard rat chow pellet and water with or without the addition of 2 mg/g body weight MSG/day in drinking water (n=10 per group). Both MSG-treated and control animals were sacrificed after 9 months when renal function parameters, blood and urine electrolytes, and tissue histopathology were determined.<h4>Results</h4>MSG-treated rats were more prone to kidney stone formation, as represented by the alkaline urine and significantly higher activity product of calcium phosphate. Accordingly, 3/10 MSG-treated rats developed kidney stones over 9 months versus none of the control animals. Further, 2/10 MSG-treated rats but none (0/10) of the controls manifested hydronephrosis. MSG-treated rats had significantly higher levels of serum creatinine and potassium including urine output volume, urinary excretion sodium and citrate compared to controls. In contrast, MSG-treated rats had significantly lower ammonium and magnesium urinary excretion.<h4>Conclusion</h4>Oral MSG consumption appears to cause alkaline urine and may increase the risks of kidney stones with hydronephrosis in rats. Similar effects in humans must be verified by dedicated studies.
format	article
author	Amod Sharma Vitoon Prasongwattana Ubon Cha'on Carlo Selmi Wiphawi Hipkaeo Piyanard Boonnate Supattra Pethlert Tanin Titipungul Piyapharom Intarawichian Sakda Waraasawapati Anucha Puapiroj Visith Sitprija Sirirat Reungjui
author_facet	Amod Sharma Vitoon Prasongwattana Ubon Cha'on Carlo Selmi Wiphawi Hipkaeo Piyanard Boonnate Supattra Pethlert Tanin Titipungul Piyapharom Intarawichian Sakda Waraasawapati Anucha Puapiroj Visith Sitprija Sirirat Reungjui
author_sort	Amod Sharma
title	Monosodium glutamate (MSG) consumption is associated with urolithiasis and urinary tract obstruction in rats.
title_short	Monosodium glutamate (MSG) consumption is associated with urolithiasis and urinary tract obstruction in rats.
title_full	Monosodium glutamate (MSG) consumption is associated with urolithiasis and urinary tract obstruction in rats.
title_fullStr	Monosodium glutamate (MSG) consumption is associated with urolithiasis and urinary tract obstruction in rats.
title_full_unstemmed	Monosodium glutamate (MSG) consumption is associated with urolithiasis and urinary tract obstruction in rats.
title_sort	monosodium glutamate (msg) consumption is associated with urolithiasis and urinary tract obstruction in rats.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/ce71ca69ce9645f984ff8a53df5d42ce
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Monosodium glutamate (MSG) consumption is associated with urolithiasis and urinary tract obstruction in rats.

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