Effect of Wave Reflection and Arterial Stiffness on the Risk of Development of Hypertension in Japanese Men

BackgroundWe conducted analyses of repeated‐measures data to examine whether pressure wave reflection acts additively or synergistically with arterial stiffness in the pathogenesis of hypertension. Methods and ResultsIn 3172 middle‐aged (42±9 years) healthy Japanese men without hypertension at the s...

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Autores principales:	Hirofumi Tomiyama, Shunsuke Komatsu, Kazuki Shiina, Chisa Matsumoto, Kazutaka Kimura, Masatsune Fujii, Lisa Takahashi, Taishiro Chikamori, Akira Yamashina
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2018
Materias:	arterial stiffness augmentation index hypertension pulse wave velocity wave reflection Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/ce76ea794ecc4680a9a0984573012d8a
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spelling	oai:doaj.org-article:ce76ea794ecc4680a9a0984573012d8a2021-11-12T17:01:53ZEffect of Wave Reflection and Arterial Stiffness on the Risk of Development of Hypertension in Japanese Men10.1161/JAHA.117.0081752047-9980https://doaj.org/article/ce76ea794ecc4680a9a0984573012d8a2018-05-01T00:00:00Zhttps://www.ahajournals.org/doi/10.1161/JAHA.117.008175https://doaj.org/toc/2047-9980BackgroundWe conducted analyses of repeated‐measures data to examine whether pressure wave reflection acts additively or synergistically with arterial stiffness in the pathogenesis of hypertension. Methods and ResultsIn 3172 middle‐aged (42±9 years) healthy Japanese men without hypertension at the study baseline, systolic and diastolic blood pressures, brachial–ankle pulse wave velocity, and radial augmentation index were measured annually during a 9‐year study period. Of these, 474 participants (15%) developed hypertension by the end of the study period. Binary logistic regression analysis demonstrated significant individual odds ratios for both baseline brachial–ankle pulse wave velocity and radial augmentation index for the development of hypertension. The rate of onset of hypertension during the study period was highest in the participant group with high values for both brachial–ankle pulse wave velocity and radial augmentation index at study baseline (262 of 965 participants: 27%). The generalized estimating equation analysis revealed that both radial augmentation index (estimate=0.06, SE=0.03, P=0.05) and brachial–ankle pulse wave velocity (estimate=0.07×10−1, SE=0.02×10−1, P<0.01) showed significant longitudinal association with new onset of hypertension, with no significant interaction. ConclusionsIn Japanese men, abnormal wave reflection and increased arterial stiffness may be additively associated with the risk of new onset of hypertension. Abnormal wave reflection and elevated central blood pressure may be longitudinally associated with increase in arterial stiffness, and this longitudinal association may be a mechanism underlying the additive effect of these 2 variables on the risk of new onset of hypertension.Hirofumi TomiyamaShunsuke KomatsuKazuki ShiinaChisa MatsumotoKazutaka KimuraMasatsune FujiiLisa TakahashiTaishiro ChikamoriAkira YamashinaWileyarticlearterial stiffnessaugmentation indexhypertensionpulse wave velocitywave reflectionDiseases of the circulatory (Cardiovascular) systemRC666-701ENJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 7, Iss 10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	arterial stiffness augmentation index hypertension pulse wave velocity wave reflection Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	arterial stiffness augmentation index hypertension pulse wave velocity wave reflection Diseases of the circulatory (Cardiovascular) system RC666-701 Hirofumi Tomiyama Shunsuke Komatsu Kazuki Shiina Chisa Matsumoto Kazutaka Kimura Masatsune Fujii Lisa Takahashi Taishiro Chikamori Akira Yamashina Effect of Wave Reflection and Arterial Stiffness on the Risk of Development of Hypertension in Japanese Men
description	BackgroundWe conducted analyses of repeated‐measures data to examine whether pressure wave reflection acts additively or synergistically with arterial stiffness in the pathogenesis of hypertension. Methods and ResultsIn 3172 middle‐aged (42±9 years) healthy Japanese men without hypertension at the study baseline, systolic and diastolic blood pressures, brachial–ankle pulse wave velocity, and radial augmentation index were measured annually during a 9‐year study period. Of these, 474 participants (15%) developed hypertension by the end of the study period. Binary logistic regression analysis demonstrated significant individual odds ratios for both baseline brachial–ankle pulse wave velocity and radial augmentation index for the development of hypertension. The rate of onset of hypertension during the study period was highest in the participant group with high values for both brachial–ankle pulse wave velocity and radial augmentation index at study baseline (262 of 965 participants: 27%). The generalized estimating equation analysis revealed that both radial augmentation index (estimate=0.06, SE=0.03, P=0.05) and brachial–ankle pulse wave velocity (estimate=0.07×10−1, SE=0.02×10−1, P<0.01) showed significant longitudinal association with new onset of hypertension, with no significant interaction. ConclusionsIn Japanese men, abnormal wave reflection and increased arterial stiffness may be additively associated with the risk of new onset of hypertension. Abnormal wave reflection and elevated central blood pressure may be longitudinally associated with increase in arterial stiffness, and this longitudinal association may be a mechanism underlying the additive effect of these 2 variables on the risk of new onset of hypertension.
format	article
author	Hirofumi Tomiyama Shunsuke Komatsu Kazuki Shiina Chisa Matsumoto Kazutaka Kimura Masatsune Fujii Lisa Takahashi Taishiro Chikamori Akira Yamashina
author_facet	Hirofumi Tomiyama Shunsuke Komatsu Kazuki Shiina Chisa Matsumoto Kazutaka Kimura Masatsune Fujii Lisa Takahashi Taishiro Chikamori Akira Yamashina
author_sort	Hirofumi Tomiyama
title	Effect of Wave Reflection and Arterial Stiffness on the Risk of Development of Hypertension in Japanese Men
title_short	Effect of Wave Reflection and Arterial Stiffness on the Risk of Development of Hypertension in Japanese Men
title_full	Effect of Wave Reflection and Arterial Stiffness on the Risk of Development of Hypertension in Japanese Men
title_fullStr	Effect of Wave Reflection and Arterial Stiffness on the Risk of Development of Hypertension in Japanese Men
title_full_unstemmed	Effect of Wave Reflection and Arterial Stiffness on the Risk of Development of Hypertension in Japanese Men
title_sort	effect of wave reflection and arterial stiffness on the risk of development of hypertension in japanese men
publisher	Wiley
publishDate	2018
url	https://doaj.org/article/ce76ea794ecc4680a9a0984573012d8a
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Effect of Wave Reflection and Arterial Stiffness on the Risk of Development of Hypertension in Japanese Men

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