Epstein-Barr Virus-Positive Adrenal Diffuse Large B-Cell Lymphoma after Treatment for Angioimmunoblastic T-Cell Lymphoma

Angioimmunoblastic T-cell lymphoma (AITL) can be complicated by Epstein-Barr virus (EBV)-positive B-cell lymphoma. B-cell lymphoma may develop simultaneously at the time of AITL diagnosis or after treatment for AITL. EBV-associated B-cell lymphoma can occur in nodal and extranodal sites. We report a...

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Autores principales:	Akiko Hashimoto, Satsuki Asai, Yasuhiro Tanaka, Isaku Shinzato
Formato:	article
Lenguaje:	EN
Publicado:	SMC MEDIA SRL 2021
Materias:	adrenal mass diffuse large b-cell lymphoma epstein-barr virus angioimmunoblastic t-cell lymphoma Medicine R
Acceso en línea:	https://doaj.org/article/ce774f55475b42b7b6d8a13669d7e886
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spelling	oai:doaj.org-article:ce774f55475b42b7b6d8a13669d7e8862021-11-09T11:21:26ZEpstein-Barr Virus-Positive Adrenal Diffuse Large B-Cell Lymphoma after Treatment for Angioimmunoblastic T-Cell Lymphoma2284-259410.12890/2021_002533https://doaj.org/article/ce774f55475b42b7b6d8a13669d7e8862021-10-01T00:00:00Zhttps://www.ejcrim.com/index.php/EJCRIM/article/view/2533https://doaj.org/toc/2284-2594Angioimmunoblastic T-cell lymphoma (AITL) can be complicated by Epstein-Barr virus (EBV)-positive B-cell lymphoma. B-cell lymphoma may develop simultaneously at the time of AITL diagnosis or after treatment for AITL. EBV-associated B-cell lymphoma can occur in nodal and extranodal sites. We report a case of EBV-positive diffuse large B-cell lymphoma (DLBCL) of the left adrenal gland that developed after treatment for AITL. The patient presented with systemic lymphadenopathy and biopsy of one lymph node showed AITL. A complete response (CR) was achieved after initial chemotherapy for AITL, but 9 months later the left adrenal gland was enlarged. The diagnosis of EBV-positive DLBCL was made based on the histopathological findings of the left adrenal gland biopsy. Thus, EBV-positive DLBCL developed after AITL CR was achieved. Multi-drug chemotherapy combined with rituximab was administered for adrenal DLBCL, but only a partial response was achieved. We confirmed that EBV-positive B-cell lymphoma developed after treatment for AITL. An adrenal primary is rare, and this is only the second case of EBV-positive B-cell lymphoma to be reported after treatment for AITL. Clinicians should keep in mind that when nodal and extranodal lesions are seen after AITL treatment, another biopsy should be performed for the accurate determination of whether these lesions indicate AITL relapse or new-onset EBV-positive B-cell lymphoma.Akiko HashimotoSatsuki AsaiYasuhiro TanakaIsaku ShinzatoSMC MEDIA SRLarticleadrenal massdiffuse large b-cell lymphomaepstein-barr virusangioimmunoblastic t-cell lymphomaMedicineRENEuropean Journal of Case Reports in Internal Medicine (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	adrenal mass diffuse large b-cell lymphoma epstein-barr virus angioimmunoblastic t-cell lymphoma Medicine R
spellingShingle	adrenal mass diffuse large b-cell lymphoma epstein-barr virus angioimmunoblastic t-cell lymphoma Medicine R Akiko Hashimoto Satsuki Asai Yasuhiro Tanaka Isaku Shinzato Epstein-Barr Virus-Positive Adrenal Diffuse Large B-Cell Lymphoma after Treatment for Angioimmunoblastic T-Cell Lymphoma
description	Angioimmunoblastic T-cell lymphoma (AITL) can be complicated by Epstein-Barr virus (EBV)-positive B-cell lymphoma. B-cell lymphoma may develop simultaneously at the time of AITL diagnosis or after treatment for AITL. EBV-associated B-cell lymphoma can occur in nodal and extranodal sites. We report a case of EBV-positive diffuse large B-cell lymphoma (DLBCL) of the left adrenal gland that developed after treatment for AITL. The patient presented with systemic lymphadenopathy and biopsy of one lymph node showed AITL. A complete response (CR) was achieved after initial chemotherapy for AITL, but 9 months later the left adrenal gland was enlarged. The diagnosis of EBV-positive DLBCL was made based on the histopathological findings of the left adrenal gland biopsy. Thus, EBV-positive DLBCL developed after AITL CR was achieved. Multi-drug chemotherapy combined with rituximab was administered for adrenal DLBCL, but only a partial response was achieved. We confirmed that EBV-positive B-cell lymphoma developed after treatment for AITL. An adrenal primary is rare, and this is only the second case of EBV-positive B-cell lymphoma to be reported after treatment for AITL. Clinicians should keep in mind that when nodal and extranodal lesions are seen after AITL treatment, another biopsy should be performed for the accurate determination of whether these lesions indicate AITL relapse or new-onset EBV-positive B-cell lymphoma.
format	article
author	Akiko Hashimoto Satsuki Asai Yasuhiro Tanaka Isaku Shinzato
author_facet	Akiko Hashimoto Satsuki Asai Yasuhiro Tanaka Isaku Shinzato
author_sort	Akiko Hashimoto
title	Epstein-Barr Virus-Positive Adrenal Diffuse Large B-Cell Lymphoma after Treatment for Angioimmunoblastic T-Cell Lymphoma
title_short	Epstein-Barr Virus-Positive Adrenal Diffuse Large B-Cell Lymphoma after Treatment for Angioimmunoblastic T-Cell Lymphoma
title_full	Epstein-Barr Virus-Positive Adrenal Diffuse Large B-Cell Lymphoma after Treatment for Angioimmunoblastic T-Cell Lymphoma
title_fullStr	Epstein-Barr Virus-Positive Adrenal Diffuse Large B-Cell Lymphoma after Treatment for Angioimmunoblastic T-Cell Lymphoma
title_full_unstemmed	Epstein-Barr Virus-Positive Adrenal Diffuse Large B-Cell Lymphoma after Treatment for Angioimmunoblastic T-Cell Lymphoma
title_sort	epstein-barr virus-positive adrenal diffuse large b-cell lymphoma after treatment for angioimmunoblastic t-cell lymphoma
publisher	SMC MEDIA SRL
publishDate	2021
url	https://doaj.org/article/ce774f55475b42b7b6d8a13669d7e886
work_keys_str_mv	AT akikohashimoto epsteinbarrviruspositiveadrenaldiffuselargebcelllymphomaaftertreatmentforangioimmunoblastictcelllymphoma AT satsukiasai epsteinbarrviruspositiveadrenaldiffuselargebcelllymphomaaftertreatmentforangioimmunoblastictcelllymphoma AT yasuhirotanaka epsteinbarrviruspositiveadrenaldiffuselargebcelllymphomaaftertreatmentforangioimmunoblastictcelllymphoma AT isakushinzato epsteinbarrviruspositiveadrenaldiffuselargebcelllymphomaaftertreatmentforangioimmunoblastictcelllymphoma
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Epstein-Barr Virus-Positive Adrenal Diffuse Large B-Cell Lymphoma after Treatment for Angioimmunoblastic T-Cell Lymphoma

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