Hepatitis B virus screening in patients with non-Hodgkin lymphoma in clinical practice in Poland – a report of the Polish Lymphoma Research Group

Introduction The risk of HBV reactivation is important in lymphoma patients receiving immunosuppressive chemotherapy containing steroids or anti-CD20 antibodies. We aimed to establish the prevalence of HBV Ag and anti-HBc serologic positive results in patients with non-Hodgkin lymphoma (NHL) and chr...

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Autores principales:	Ewa Kalinka, Joanna Drozd-Sokołowska, Anna Waszczuk-Gajda, Joanna Barankiewicz, Elżbieta Zalewska, Igor Symonowicz, Ewa Lech-Marańda
Formato:	article
Lenguaje:	EN
Publicado:	Termedia Publishing House 2019
Materias:	screening chronic lymphocytic leukemia hepatitis b virus non-hodgkin lymphoma anti-cd20 treatment Medicine R
Acceso en línea:	https://doaj.org/article/ce78f69cb9b744468c38171ba90af4e1
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spelling	oai:doaj.org-article:ce78f69cb9b744468c38171ba90af4e12021-12-02T16:59:25ZHepatitis B virus screening in patients with non-Hodgkin lymphoma in clinical practice in Poland – a report of the Polish Lymphoma Research Group1734-19221896-915110.5114/aoms.2019.86761https://doaj.org/article/ce78f69cb9b744468c38171ba90af4e12019-12-01T00:00:00Zhttps://www.archivesofmedicalscience.com/Hepatitis-B-virus-screening-in-patients-with-non-Hodgkin-lymphoma-in-clinical-practice,110207,0,2.htmlhttps://doaj.org/toc/1734-1922https://doaj.org/toc/1896-9151Introduction The risk of HBV reactivation is important in lymphoma patients receiving immunosuppressive chemotherapy containing steroids or anti-CD20 antibodies. We aimed to establish the prevalence of HBV Ag and anti-HBc serologic positive results in patients with non-Hodgkin lymphoma (NHL) and chronic lymphocytic leukemia (CLL) in Poland before anti-CD20 therapy initiation; to assess the frequency of insufficient HBV screening; and to assess the association between inadequate HBV screening and diagnosis according to the WHO classification and age or gender. Material and methods We retrospectively collected data from 805 patients with non-Hodgkin lymphoma and chronic lymphocytic leukemia treated in 2016–2018. Results We found a positive result of HBsAg in 13 (1.16%), and a negative result in 633 (78.64%) patients. The test was not done in 159 (19.75%) patients. In the HBsAg negative subgroup of 633 patients, we found that the anti-HBc was positive in 52 (8.22%), negative in 303 (47.87%) and not done in 278 patients. In 136 out of 805 (16.9%) patients diagnostics tests were not performed before therapy initiation. We found that age is significantly associated (p = 0.0002) with the lack of HBV infection screening, and in CLL this risk is significantly (p = 0.024) higher (by 49%) compared with other WHO diagnosis subgroups. Conclusions In Polish lymphoma patients the incidence of positive HBsAg and/or anti-HBc results is consistent with the prevalence in the United States or Australia. The adherence to appropriate HBV screening guidelines in Polish centers is not sufficient. We should intensify educational strategies in the global oncohematologic medical community.Ewa KalinkaJoanna Drozd-SokołowskaAnna Waszczuk-GajdaJoanna BarankiewiczElżbieta ZalewskaIgor SymonowiczEwa Lech-MarańdaTermedia Publishing Housearticlescreeningchronic lymphocytic leukemiahepatitis b virusnon-hodgkin lymphomaanti-cd20 treatmentMedicineRENArchives of Medical Science, Vol 16, Iss 1, Pp 157-161 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	screening chronic lymphocytic leukemia hepatitis b virus non-hodgkin lymphoma anti-cd20 treatment Medicine R
spellingShingle	screening chronic lymphocytic leukemia hepatitis b virus non-hodgkin lymphoma anti-cd20 treatment Medicine R Ewa Kalinka Joanna Drozd-Sokołowska Anna Waszczuk-Gajda Joanna Barankiewicz Elżbieta Zalewska Igor Symonowicz Ewa Lech-Marańda Hepatitis B virus screening in patients with non-Hodgkin lymphoma in clinical practice in Poland – a report of the Polish Lymphoma Research Group
description	Introduction The risk of HBV reactivation is important in lymphoma patients receiving immunosuppressive chemotherapy containing steroids or anti-CD20 antibodies. We aimed to establish the prevalence of HBV Ag and anti-HBc serologic positive results in patients with non-Hodgkin lymphoma (NHL) and chronic lymphocytic leukemia (CLL) in Poland before anti-CD20 therapy initiation; to assess the frequency of insufficient HBV screening; and to assess the association between inadequate HBV screening and diagnosis according to the WHO classification and age or gender. Material and methods We retrospectively collected data from 805 patients with non-Hodgkin lymphoma and chronic lymphocytic leukemia treated in 2016–2018. Results We found a positive result of HBsAg in 13 (1.16%), and a negative result in 633 (78.64%) patients. The test was not done in 159 (19.75%) patients. In the HBsAg negative subgroup of 633 patients, we found that the anti-HBc was positive in 52 (8.22%), negative in 303 (47.87%) and not done in 278 patients. In 136 out of 805 (16.9%) patients diagnostics tests were not performed before therapy initiation. We found that age is significantly associated (p = 0.0002) with the lack of HBV infection screening, and in CLL this risk is significantly (p = 0.024) higher (by 49%) compared with other WHO diagnosis subgroups. Conclusions In Polish lymphoma patients the incidence of positive HBsAg and/or anti-HBc results is consistent with the prevalence in the United States or Australia. The adherence to appropriate HBV screening guidelines in Polish centers is not sufficient. We should intensify educational strategies in the global oncohematologic medical community.
format	article
author	Ewa Kalinka Joanna Drozd-Sokołowska Anna Waszczuk-Gajda Joanna Barankiewicz Elżbieta Zalewska Igor Symonowicz Ewa Lech-Marańda
author_facet	Ewa Kalinka Joanna Drozd-Sokołowska Anna Waszczuk-Gajda Joanna Barankiewicz Elżbieta Zalewska Igor Symonowicz Ewa Lech-Marańda
author_sort	Ewa Kalinka
title	Hepatitis B virus screening in patients with non-Hodgkin lymphoma in clinical practice in Poland – a report of the Polish Lymphoma Research Group
title_short	Hepatitis B virus screening in patients with non-Hodgkin lymphoma in clinical practice in Poland – a report of the Polish Lymphoma Research Group
title_full	Hepatitis B virus screening in patients with non-Hodgkin lymphoma in clinical practice in Poland – a report of the Polish Lymphoma Research Group
title_fullStr	Hepatitis B virus screening in patients with non-Hodgkin lymphoma in clinical practice in Poland – a report of the Polish Lymphoma Research Group
title_full_unstemmed	Hepatitis B virus screening in patients with non-Hodgkin lymphoma in clinical practice in Poland – a report of the Polish Lymphoma Research Group
title_sort	hepatitis b virus screening in patients with non-hodgkin lymphoma in clinical practice in poland – a report of the polish lymphoma research group
publisher	Termedia Publishing House
publishDate	2019
url	https://doaj.org/article/ce78f69cb9b744468c38171ba90af4e1
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Hepatitis B virus screening in patients with non-Hodgkin lymphoma in clinical practice in Poland – a report of the Polish Lymphoma Research Group

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