Acute Phase Proteins Are Baseline Predictors of Tuberculosis Treatment Failure

Systemic inflammation is a characteristic feature of pulmonary tuberculosis (PTB). Whether systemic inflammation is associated with treatment failure in PTB is not known. Participants, who were newly diagnosed, sputum smear and culture positive individuals with drug-sensitive PTB, were treated with...

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Autores principales:	Nathella Pavan Kumar, Kadar Moideen, Arul Nancy, Vijay Viswanathan, Kannan Thiruvengadam, Shanmugam Sivakumar, Syed Hissar, Hardy Kornfeld, Subash Babu
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	tuberculosis acute phase proteins biomarker inflammation TB treatment Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/ce7dffabad994170a8c391737f6a97a8
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spelling	oai:doaj.org-article:ce7dffabad994170a8c391737f6a97a82021-11-15T06:11:39ZAcute Phase Proteins Are Baseline Predictors of Tuberculosis Treatment Failure1664-322410.3389/fimmu.2021.731878https://doaj.org/article/ce7dffabad994170a8c391737f6a97a82021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.731878/fullhttps://doaj.org/toc/1664-3224Systemic inflammation is a characteristic feature of pulmonary tuberculosis (PTB). Whether systemic inflammation is associated with treatment failure in PTB is not known. Participants, who were newly diagnosed, sputum smear and culture positive individuals with drug-sensitive PTB, were treated with standard anti-tuberculosis treatment and classified as having treatment failure or microbiological cure. The plasma levels of acute phase proteins were assessed at baseline (pre-treatment). Baseline levels of C-reactive protein (CRP), alpha-2 macroglobulin (a2M), Haptoglobin and serum amyloid P (SAP) were significantly higher in treatment failure compared to cured individuals. ROC curve analysis demonstrated the utility of these individual markers in discriminating treatment failure from cure. Finally, combined ROC analysis revealed high sensitivity and specificity of 3 marker signatures comprising of CRP, a2M and SAP in distinguishing treatment failure from cured individuals with a sensitivity of 100%, specificity of 100% and area under the curve of 1. Therefore, acute phase proteins are very accurate baseline predictors of PTB treatment failure. If validated in larger cohorts, these markers hold promise for a rapid prognostic testing for adverse treatment outcomes in PTB.Nathella Pavan KumarKadar MoideenArul NancyVijay ViswanathanKannan ThiruvengadamShanmugam SivakumarSyed HissarHardy KornfeldSubash BabuSubash BabuFrontiers Media S.A.articletuberculosisacute phase proteinsbiomarkerinflammationTB treatmentImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	tuberculosis acute phase proteins biomarker inflammation TB treatment Immunologic diseases. Allergy RC581-607
spellingShingle	tuberculosis acute phase proteins biomarker inflammation TB treatment Immunologic diseases. Allergy RC581-607 Nathella Pavan Kumar Kadar Moideen Arul Nancy Vijay Viswanathan Kannan Thiruvengadam Shanmugam Sivakumar Syed Hissar Hardy Kornfeld Subash Babu Subash Babu Acute Phase Proteins Are Baseline Predictors of Tuberculosis Treatment Failure
description	Systemic inflammation is a characteristic feature of pulmonary tuberculosis (PTB). Whether systemic inflammation is associated with treatment failure in PTB is not known. Participants, who were newly diagnosed, sputum smear and culture positive individuals with drug-sensitive PTB, were treated with standard anti-tuberculosis treatment and classified as having treatment failure or microbiological cure. The plasma levels of acute phase proteins were assessed at baseline (pre-treatment). Baseline levels of C-reactive protein (CRP), alpha-2 macroglobulin (a2M), Haptoglobin and serum amyloid P (SAP) were significantly higher in treatment failure compared to cured individuals. ROC curve analysis demonstrated the utility of these individual markers in discriminating treatment failure from cure. Finally, combined ROC analysis revealed high sensitivity and specificity of 3 marker signatures comprising of CRP, a2M and SAP in distinguishing treatment failure from cured individuals with a sensitivity of 100%, specificity of 100% and area under the curve of 1. Therefore, acute phase proteins are very accurate baseline predictors of PTB treatment failure. If validated in larger cohorts, these markers hold promise for a rapid prognostic testing for adverse treatment outcomes in PTB.
format	article
author	Nathella Pavan Kumar Kadar Moideen Arul Nancy Vijay Viswanathan Kannan Thiruvengadam Shanmugam Sivakumar Syed Hissar Hardy Kornfeld Subash Babu Subash Babu
author_facet	Nathella Pavan Kumar Kadar Moideen Arul Nancy Vijay Viswanathan Kannan Thiruvengadam Shanmugam Sivakumar Syed Hissar Hardy Kornfeld Subash Babu Subash Babu
author_sort	Nathella Pavan Kumar
title	Acute Phase Proteins Are Baseline Predictors of Tuberculosis Treatment Failure
title_short	Acute Phase Proteins Are Baseline Predictors of Tuberculosis Treatment Failure
title_full	Acute Phase Proteins Are Baseline Predictors of Tuberculosis Treatment Failure
title_fullStr	Acute Phase Proteins Are Baseline Predictors of Tuberculosis Treatment Failure
title_full_unstemmed	Acute Phase Proteins Are Baseline Predictors of Tuberculosis Treatment Failure
title_sort	acute phase proteins are baseline predictors of tuberculosis treatment failure
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/ce7dffabad994170a8c391737f6a97a8
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Acute Phase Proteins Are Baseline Predictors of Tuberculosis Treatment Failure

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