Persistent circulation of Coxsackievirus A6 of genotype D3 in mainland of China between 2008 and 2015

Abstract A total of 807 entire VP1 sequences of Coxsackievirus A6 (CV-A6) from mainland of China from 1992 to 2015, including 520 in this study and 287 from the GenBank database, were analysed to provide a basic framework of molecular epidemiological characteristics of CV-A6 in China. Sixty-five VP1...

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Autores principales:	Yang Song, Yong Zhang, Tianjiao Ji, Xinrui Gu, Qian Yang, Shuangli Zhu, Wen Xu, Yi Xu, Yong Shi, Xueyong Huang, Qi Li, Hong Deng, Xianjun Wang, Dongmei Yan, Wei Yu, Shuang Wang, Deshan Yu, Wenbo Xu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ce809796da1340a7b8d76967b63affc0
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spelling	oai:doaj.org-article:ce809796da1340a7b8d76967b63affc02021-12-02T16:07:01ZPersistent circulation of Coxsackievirus A6 of genotype D3 in mainland of China between 2008 and 201510.1038/s41598-017-05618-02045-2322https://doaj.org/article/ce809796da1340a7b8d76967b63affc02017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05618-0https://doaj.org/toc/2045-2322Abstract A total of 807 entire VP1 sequences of Coxsackievirus A6 (CV-A6) from mainland of China from 1992 to 2015, including 520 in this study and 287 from the GenBank database, were analysed to provide a basic framework of molecular epidemiological characteristics of CV-A6 in China. Sixty-five VP1 sequences including 46 representative CV-A6 isolates from 807 Chinese strains and 19 international strains from GenBank were used for describing the genotypes and sub-genotypes. The results revealed that CV-A6 strains can be categorised into 4 genotypes designated as A, B, C, and D according to previous data and can be further subdivided into B1–B2, C1–C2, and D1–D3 sub-genotypes. D3 is the predominant sub-genotype that circulated in recent years in mainland of China and represents 734 of 807 Chinese isolates. Sixty-six strains belong to D2, whereas B1 and C1 comprise a single strain each, and five AFP strains formed B2. Sub-genotype D3 first circulated in 2008 and has become the predominant sub-genotype since 2009 and then reached a peak in 2013, while D2 was mostly undetectable in the past years. These data revealed different transmission stages of CV-A6 in mainland of China and that sub-genotype D3 may have stronger transmission ability.Yang SongYong ZhangTianjiao JiXinrui GuQian YangShuangli ZhuWen XuYi XuYong ShiXueyong HuangQi LiHong DengXianjun WangDongmei YanWei YuShuang WangDeshan YuWenbo XuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yang Song Yong Zhang Tianjiao Ji Xinrui Gu Qian Yang Shuangli Zhu Wen Xu Yi Xu Yong Shi Xueyong Huang Qi Li Hong Deng Xianjun Wang Dongmei Yan Wei Yu Shuang Wang Deshan Yu Wenbo Xu Persistent circulation of Coxsackievirus A6 of genotype D3 in mainland of China between 2008 and 2015
description	Abstract A total of 807 entire VP1 sequences of Coxsackievirus A6 (CV-A6) from mainland of China from 1992 to 2015, including 520 in this study and 287 from the GenBank database, were analysed to provide a basic framework of molecular epidemiological characteristics of CV-A6 in China. Sixty-five VP1 sequences including 46 representative CV-A6 isolates from 807 Chinese strains and 19 international strains from GenBank were used for describing the genotypes and sub-genotypes. The results revealed that CV-A6 strains can be categorised into 4 genotypes designated as A, B, C, and D according to previous data and can be further subdivided into B1–B2, C1–C2, and D1–D3 sub-genotypes. D3 is the predominant sub-genotype that circulated in recent years in mainland of China and represents 734 of 807 Chinese isolates. Sixty-six strains belong to D2, whereas B1 and C1 comprise a single strain each, and five AFP strains formed B2. Sub-genotype D3 first circulated in 2008 and has become the predominant sub-genotype since 2009 and then reached a peak in 2013, while D2 was mostly undetectable in the past years. These data revealed different transmission stages of CV-A6 in mainland of China and that sub-genotype D3 may have stronger transmission ability.
format	article
author	Yang Song Yong Zhang Tianjiao Ji Xinrui Gu Qian Yang Shuangli Zhu Wen Xu Yi Xu Yong Shi Xueyong Huang Qi Li Hong Deng Xianjun Wang Dongmei Yan Wei Yu Shuang Wang Deshan Yu Wenbo Xu
author_facet	Yang Song Yong Zhang Tianjiao Ji Xinrui Gu Qian Yang Shuangli Zhu Wen Xu Yi Xu Yong Shi Xueyong Huang Qi Li Hong Deng Xianjun Wang Dongmei Yan Wei Yu Shuang Wang Deshan Yu Wenbo Xu
author_sort	Yang Song
title	Persistent circulation of Coxsackievirus A6 of genotype D3 in mainland of China between 2008 and 2015
title_short	Persistent circulation of Coxsackievirus A6 of genotype D3 in mainland of China between 2008 and 2015
title_full	Persistent circulation of Coxsackievirus A6 of genotype D3 in mainland of China between 2008 and 2015
title_fullStr	Persistent circulation of Coxsackievirus A6 of genotype D3 in mainland of China between 2008 and 2015
title_full_unstemmed	Persistent circulation of Coxsackievirus A6 of genotype D3 in mainland of China between 2008 and 2015
title_sort	persistent circulation of coxsackievirus a6 of genotype d3 in mainland of china between 2008 and 2015
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/ce809796da1340a7b8d76967b63affc0
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_version_	1718384806353436672

Persistent circulation of Coxsackievirus A6 of genotype D3 in mainland of China between 2008 and 2015

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