Computational identification of mutually exclusive transcriptional drivers dysregulating metastatic microRNAs in prostate cancer

Dysregulation of microRNAs is thought to be important for metastasis in castration-resistant prostate cancer (CRPC), but its drivers are unknown. Here, the authors use computational analysis to identify HOXC6 and NKX2-2 in addition to AR as alternative drivers of dysregulated miRNA expression in CRP...

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Autores principales: Mengzhu Xue, Haiyue Liu, Liwen Zhang, Hongyuan Chang, Yuwei Liu, Shaowei Du, Yingqun Yang, Peng Wang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/ce82cd37286442e5beb67f365453902b
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Sumario:Dysregulation of microRNAs is thought to be important for metastasis in castration-resistant prostate cancer (CRPC), but its drivers are unknown. Here, the authors use computational analysis to identify HOXC6 and NKX2-2 in addition to AR as alternative drivers of dysregulated miRNA expression in CRPC.