Computational identification of mutually exclusive transcriptional drivers dysregulating metastatic microRNAs in prostate cancer

Dysregulation of microRNAs is thought to be important for metastasis in castration-resistant prostate cancer (CRPC), but its drivers are unknown. Here, the authors use computational analysis to identify HOXC6 and NKX2-2 in addition to AR as alternative drivers of dysregulated miRNA expression in CRP...

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Autores principales:	Mengzhu Xue, Haiyue Liu, Liwen Zhang, Hongyuan Chang, Yuwei Liu, Shaowei Du, Yingqun Yang, Peng Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ce82cd37286442e5beb67f365453902b
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spelling	oai:doaj.org-article:ce82cd37286442e5beb67f365453902b2021-12-02T15:37:02ZComputational identification of mutually exclusive transcriptional drivers dysregulating metastatic microRNAs in prostate cancer10.1038/ncomms149172041-1723https://doaj.org/article/ce82cd37286442e5beb67f365453902b2017-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms14917https://doaj.org/toc/2041-1723Dysregulation of microRNAs is thought to be important for metastasis in castration-resistant prostate cancer (CRPC), but its drivers are unknown. Here, the authors use computational analysis to identify HOXC6 and NKX2-2 in addition to AR as alternative drivers of dysregulated miRNA expression in CRPC.Mengzhu XueHaiyue LiuLiwen ZhangHongyuan ChangYuwei LiuShaowei DuYingqun YangPeng WangNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mengzhu Xue Haiyue Liu Liwen Zhang Hongyuan Chang Yuwei Liu Shaowei Du Yingqun Yang Peng Wang Computational identification of mutually exclusive transcriptional drivers dysregulating metastatic microRNAs in prostate cancer
description	Dysregulation of microRNAs is thought to be important for metastasis in castration-resistant prostate cancer (CRPC), but its drivers are unknown. Here, the authors use computational analysis to identify HOXC6 and NKX2-2 in addition to AR as alternative drivers of dysregulated miRNA expression in CRPC.
format	article
author	Mengzhu Xue Haiyue Liu Liwen Zhang Hongyuan Chang Yuwei Liu Shaowei Du Yingqun Yang Peng Wang
author_facet	Mengzhu Xue Haiyue Liu Liwen Zhang Hongyuan Chang Yuwei Liu Shaowei Du Yingqun Yang Peng Wang
author_sort	Mengzhu Xue
title	Computational identification of mutually exclusive transcriptional drivers dysregulating metastatic microRNAs in prostate cancer
title_short	Computational identification of mutually exclusive transcriptional drivers dysregulating metastatic microRNAs in prostate cancer
title_full	Computational identification of mutually exclusive transcriptional drivers dysregulating metastatic microRNAs in prostate cancer
title_fullStr	Computational identification of mutually exclusive transcriptional drivers dysregulating metastatic microRNAs in prostate cancer
title_full_unstemmed	Computational identification of mutually exclusive transcriptional drivers dysregulating metastatic microRNAs in prostate cancer
title_sort	computational identification of mutually exclusive transcriptional drivers dysregulating metastatic micrornas in prostate cancer
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/ce82cd37286442e5beb67f365453902b
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Computational identification of mutually exclusive transcriptional drivers dysregulating metastatic microRNAs in prostate cancer

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