Systematic review and meta-analysis of the associations of vegan and vegetarian diets with inflammatory biomarkers

Abstract Plant-based diets like vegetarian or vegan diets might influence circulating levels of inflammatory biomarkers, thereby reducing the risk of chronic diseases. This systematic review and meta-analysis aimed to investigate the associations of veganism and vegetarianism with circulating inflam...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Juliane Menzel, Afraa Jabakhanji, Ronald Biemann, Knut Mai, Klaus Abraham, Cornelia Weikert
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ce84c45d8cb949beb72c5db6de233ba0
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ce84c45d8cb949beb72c5db6de233ba0
record_format	dspace
spelling	oai:doaj.org-article:ce84c45d8cb949beb72c5db6de233ba02021-12-02T11:43:36ZSystematic review and meta-analysis of the associations of vegan and vegetarian diets with inflammatory biomarkers10.1038/s41598-020-78426-82045-2322https://doaj.org/article/ce84c45d8cb949beb72c5db6de233ba02020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-78426-8https://doaj.org/toc/2045-2322Abstract Plant-based diets like vegetarian or vegan diets might influence circulating levels of inflammatory biomarkers, thereby reducing the risk of chronic diseases. This systematic review and meta-analysis aimed to investigate the associations of veganism and vegetarianism with circulating inflammatory biomarkers in comparison to omnivores. Literature search was conducted in Pubmed and EMBASE until April 2020 and mean differences of biomarkers were assessed for: C-reactive protein (CRP), interleukin-6 (IL-6), interleukin-18 (IL-18), interleukin-1 receptor antagonist (IL-1 RA), tumor necrosis factor-alpha (TNF-ɑ), E-selectin, intercellular adhesion molecule-1 (ICAM-1), monocyte chemoattractant protein-1 (MCP-1), adiponectin, omentin-1 and resistin. Of initially identified 1073 publications, 21 cross-sectional studies met the inclusion criteria and were included in the systematic review and meta-analysis. Vegan diet was associated with lower levels of CRP compared to omnivores [mean difference − 0.54 mg/l, 95%-CI: − 0.79 to − 0.28, p < 0.0001]. This association was less pronounced in vegetarians [mean difference − 0.25 mg/l, 95%-CI: − 0.49 to 0.00, p = 0.05]. In patients with impaired kidney function, the association between vegetarian nutrition and CRP was much stronger with − 3.91 mg/l (95%-CI: − 5.23 to − 2.60; p < 0.0001). No substantial effects were observed for all other inflammatory biomarkers. Despite strong associations between CRP and a vegan or vegetarian diet were seen, further research is needed, as most inflammatory biomarkers were investigated only in single studies so far.Juliane MenzelAfraa JabakhanjiRonald BiemannKnut MaiKlaus AbrahamCornelia WeikertNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Juliane Menzel Afraa Jabakhanji Ronald Biemann Knut Mai Klaus Abraham Cornelia Weikert Systematic review and meta-analysis of the associations of vegan and vegetarian diets with inflammatory biomarkers
description	Abstract Plant-based diets like vegetarian or vegan diets might influence circulating levels of inflammatory biomarkers, thereby reducing the risk of chronic diseases. This systematic review and meta-analysis aimed to investigate the associations of veganism and vegetarianism with circulating inflammatory biomarkers in comparison to omnivores. Literature search was conducted in Pubmed and EMBASE until April 2020 and mean differences of biomarkers were assessed for: C-reactive protein (CRP), interleukin-6 (IL-6), interleukin-18 (IL-18), interleukin-1 receptor antagonist (IL-1 RA), tumor necrosis factor-alpha (TNF-ɑ), E-selectin, intercellular adhesion molecule-1 (ICAM-1), monocyte chemoattractant protein-1 (MCP-1), adiponectin, omentin-1 and resistin. Of initially identified 1073 publications, 21 cross-sectional studies met the inclusion criteria and were included in the systematic review and meta-analysis. Vegan diet was associated with lower levels of CRP compared to omnivores [mean difference − 0.54 mg/l, 95%-CI: − 0.79 to − 0.28, p < 0.0001]. This association was less pronounced in vegetarians [mean difference − 0.25 mg/l, 95%-CI: − 0.49 to 0.00, p = 0.05]. In patients with impaired kidney function, the association between vegetarian nutrition and CRP was much stronger with − 3.91 mg/l (95%-CI: − 5.23 to − 2.60; p < 0.0001). No substantial effects were observed for all other inflammatory biomarkers. Despite strong associations between CRP and a vegan or vegetarian diet were seen, further research is needed, as most inflammatory biomarkers were investigated only in single studies so far.
format	article
author	Juliane Menzel Afraa Jabakhanji Ronald Biemann Knut Mai Klaus Abraham Cornelia Weikert
author_facet	Juliane Menzel Afraa Jabakhanji Ronald Biemann Knut Mai Klaus Abraham Cornelia Weikert
author_sort	Juliane Menzel
title	Systematic review and meta-analysis of the associations of vegan and vegetarian diets with inflammatory biomarkers
title_short	Systematic review and meta-analysis of the associations of vegan and vegetarian diets with inflammatory biomarkers
title_full	Systematic review and meta-analysis of the associations of vegan and vegetarian diets with inflammatory biomarkers
title_fullStr	Systematic review and meta-analysis of the associations of vegan and vegetarian diets with inflammatory biomarkers
title_full_unstemmed	Systematic review and meta-analysis of the associations of vegan and vegetarian diets with inflammatory biomarkers
title_sort	systematic review and meta-analysis of the associations of vegan and vegetarian diets with inflammatory biomarkers
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/ce84c45d8cb949beb72c5db6de233ba0
work_keys_str_mv	AT julianemenzel systematicreviewandmetaanalysisoftheassociationsofveganandvegetariandietswithinflammatorybiomarkers AT afraajabakhanji systematicreviewandmetaanalysisoftheassociationsofveganandvegetariandietswithinflammatorybiomarkers AT ronaldbiemann systematicreviewandmetaanalysisoftheassociationsofveganandvegetariandietswithinflammatorybiomarkers AT knutmai systematicreviewandmetaanalysisoftheassociationsofveganandvegetariandietswithinflammatorybiomarkers AT klausabraham systematicreviewandmetaanalysisoftheassociationsofveganandvegetariandietswithinflammatorybiomarkers AT corneliaweikert systematicreviewandmetaanalysisoftheassociationsofveganandvegetariandietswithinflammatorybiomarkers
_version_	1718395370520707072

Systematic review and meta-analysis of the associations of vegan and vegetarian diets with inflammatory biomarkers

Ejemplares similares