Linking gut microbiome to bone mineral density: a shotgun metagenomic dataset from 361 elderly women

Bone mass loss contributes to the risk of bone fracture in the elderly. Many factors including age, obesity, estrogen and diet, are associated with bone mass loss. Mice studies suggested that the gut microbiome might affect the bone mass by regulating the immune system. However, there h...

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Autores principales:	Qi Wang, Qiang Sun, Xiaoping Li, Zhefeng Wang, Haotian Zheng, Yanmei Ju, Ruijin Guo, Songlin Peng, Huijue Jia
Formato:	article
Lenguaje:	EN
Publicado:	GigaScience Press 2021
Materias:	Electronic computers. Computer science QA75.5-76.95
Acceso en línea:	https://doaj.org/article/ce84f584feda4e1b8c61387b08683ce7
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id	oai:doaj.org-article:ce84f584feda4e1b8c61387b08683ce7
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spelling	oai:doaj.org-article:ce84f584feda4e1b8c61387b08683ce72021-12-02T18:04:35ZLinking gut microbiome to bone mineral density: a shotgun metagenomic dataset from 361 elderly women10.46471/gigabyte.122709-4715https://doaj.org/article/ce84f584feda4e1b8c61387b08683ce72021-01-01T00:00:00Zhttps://gigabytejournal.com/articles/12https://doaj.org/toc/2709-4715 Bone mass loss contributes to the risk of bone fracture in the elderly. Many factors including age, obesity, estrogen and diet, are associated with bone mass loss. Mice studies suggested that the gut microbiome might affect the bone mass by regulating the immune system. However, there has been little evidence from human studies. Bone loss increases after menopause. Therefore, we have recruited 361 Chinese post-menopausal women to collect their fecal samples and metadata to conduct a metagenome-wide association study (MWAS) to investigate the influence of the gut microbiome on bone health. Gut microbiome sequencing data were produced using the BGISEQ-500 sequencer. Bone mineral density (BMD) was calculated using a Hologic dual energy X-ray machine, and body mass index (BMI) and age were also recorded. This collected data allows exploration of the gut microbial diversity and their links to bone mass loss as well as to microbial markers for bone mineral density. In addition, these data are potentially useful in studying the role that the gut microbiota might play in bone mass loss and in exploring the process of bone mass loss. Qi WangQiang SunXiaoping LiZhefeng WangHaotian ZhengYanmei JuRuijin GuoSonglin PengHuijue JiaGigaScience PressarticleElectronic computers. Computer scienceQA75.5-76.95ENGigaByte (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Electronic computers. Computer science QA75.5-76.95
spellingShingle	Electronic computers. Computer science QA75.5-76.95 Qi Wang Qiang Sun Xiaoping Li Zhefeng Wang Haotian Zheng Yanmei Ju Ruijin Guo Songlin Peng Huijue Jia Linking gut microbiome to bone mineral density: a shotgun metagenomic dataset from 361 elderly women
description	Bone mass loss contributes to the risk of bone fracture in the elderly. Many factors including age, obesity, estrogen and diet, are associated with bone mass loss. Mice studies suggested that the gut microbiome might affect the bone mass by regulating the immune system. However, there has been little evidence from human studies. Bone loss increases after menopause. Therefore, we have recruited 361 Chinese post-menopausal women to collect their fecal samples and metadata to conduct a metagenome-wide association study (MWAS) to investigate the influence of the gut microbiome on bone health. Gut microbiome sequencing data were produced using the BGISEQ-500 sequencer. Bone mineral density (BMD) was calculated using a Hologic dual energy X-ray machine, and body mass index (BMI) and age were also recorded. This collected data allows exploration of the gut microbial diversity and their links to bone mass loss as well as to microbial markers for bone mineral density. In addition, these data are potentially useful in studying the role that the gut microbiota might play in bone mass loss and in exploring the process of bone mass loss.
format	article
author	Qi Wang Qiang Sun Xiaoping Li Zhefeng Wang Haotian Zheng Yanmei Ju Ruijin Guo Songlin Peng Huijue Jia
author_facet	Qi Wang Qiang Sun Xiaoping Li Zhefeng Wang Haotian Zheng Yanmei Ju Ruijin Guo Songlin Peng Huijue Jia
author_sort	Qi Wang
title	Linking gut microbiome to bone mineral density: a shotgun metagenomic dataset from 361 elderly women
title_short	Linking gut microbiome to bone mineral density: a shotgun metagenomic dataset from 361 elderly women
title_full	Linking gut microbiome to bone mineral density: a shotgun metagenomic dataset from 361 elderly women
title_fullStr	Linking gut microbiome to bone mineral density: a shotgun metagenomic dataset from 361 elderly women
title_full_unstemmed	Linking gut microbiome to bone mineral density: a shotgun metagenomic dataset from 361 elderly women
title_sort	linking gut microbiome to bone mineral density: a shotgun metagenomic dataset from 361 elderly women
publisher	GigaScience Press
publishDate	2021
url	https://doaj.org/article/ce84f584feda4e1b8c61387b08683ce7
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Linking gut microbiome to bone mineral density: a shotgun metagenomic dataset from 361 elderly women

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