Endothelial dysfunction in children and adolescents with type 1 diabetes mellitus and its role in the development of diabetic peripheral polyneuropathy

Aim. To measure endothelial factors (nitric oxide (NOx) metabolites, endothelin-1 (ET-1), and basic fibroblast growth factor (bFGF)) in children and adolescentswith diabetes mellitus (DM) during development of diabetic peripheral polyneuropathy (DPNP). Materials and methods. A total of 130 childre...

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Autores principales:	A A Afonin, M V Komkova, G A Galkina, N V Morozova
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2009
Materias:	endothelial dysfunction children adolescents type 1 diabetes mellitus diabetic peripheral polyneuropathy Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/ce877c0bec314671a0bc3336bfb3e184
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spelling	oai:doaj.org-article:ce877c0bec314671a0bc3336bfb3e1842021-11-14T09:00:13ZEndothelial dysfunction in children and adolescents with type 1 diabetes mellitus and its role in the development of diabetic peripheral polyneuropathy2072-03512072-037810.14341/2072-0351-5417https://doaj.org/article/ce877c0bec314671a0bc3336bfb3e1842009-03-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/5417https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Aim. To measure endothelial factors (nitric oxide (NOx) metabolites, endothelin-1 (ET-1), and basic fibroblast growth factor (bFGF)) in children and adolescentswith diabetes mellitus (DM) during development of diabetic peripheral polyneuropathy (DPNP). Materials and methods. A total of 130 children and adolescents with diabetes mellitus were examined. Duration of DM varied from 3 months to 14 years. Thecontrol group comprised 20 children and adolescents without DM or neurologic pathology. Subjective manifestations of DPNP were assessed based on thedata of a standardized Neuropathy Symptom Score (NSS) questionnaire. Neuropathy Disability Score (NDS) questionnaire was used to monitor objectivechanges of DPNP. NOx metabolites were detected with Griess reagent (Aldrich Chemical Co, USA). Serum ET-1 and bFGF were measured using solid-phaseimmunoenzyme assay (DRG, USA) and CYTIMMINE (USA) kits respectively. Results. All children and adolescents with DM1 had lower NOx and bFGF levels than controls. ET-1 level in DM patients was 3.5 times that in controls. DMpatients with DPNP had more pronounced endothelial dysfunction than DM patients without DPNP and control subjects. Patients with hyperproduction ofNOx had DM for more than 10 years and their total NDS score was significantly higher than in two other groups. Conclusion. Endothelial dysfunction in children and adolescents with type 1 diabetes mellitus progresses with the development of DPNP. Depletion of endothelialfunctional reserve is responsible for the unfavourable course of DPNP.A A AfoninM V KomkovaG A GalkinaN V MorozovaEndocrinology Research Centrearticleendothelial dysfunctionchildrenadolescentstype 1 diabetes mellitusdiabetic peripheral polyneuropathyNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 12, Iss 1, Pp 29-32 (2009)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	endothelial dysfunction children adolescents type 1 diabetes mellitus diabetic peripheral polyneuropathy Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	endothelial dysfunction children adolescents type 1 diabetes mellitus diabetic peripheral polyneuropathy Nutritional diseases. Deficiency diseases RC620-627 A A Afonin M V Komkova G A Galkina N V Morozova Endothelial dysfunction in children and adolescents with type 1 diabetes mellitus and its role in the development of diabetic peripheral polyneuropathy
description	Aim. To measure endothelial factors (nitric oxide (NOx) metabolites, endothelin-1 (ET-1), and basic fibroblast growth factor (bFGF)) in children and adolescentswith diabetes mellitus (DM) during development of diabetic peripheral polyneuropathy (DPNP). Materials and methods. A total of 130 children and adolescents with diabetes mellitus were examined. Duration of DM varied from 3 months to 14 years. Thecontrol group comprised 20 children and adolescents without DM or neurologic pathology. Subjective manifestations of DPNP were assessed based on thedata of a standardized Neuropathy Symptom Score (NSS) questionnaire. Neuropathy Disability Score (NDS) questionnaire was used to monitor objectivechanges of DPNP. NOx metabolites were detected with Griess reagent (Aldrich Chemical Co, USA). Serum ET-1 and bFGF were measured using solid-phaseimmunoenzyme assay (DRG, USA) and CYTIMMINE (USA) kits respectively. Results. All children and adolescents with DM1 had lower NOx and bFGF levels than controls. ET-1 level in DM patients was 3.5 times that in controls. DMpatients with DPNP had more pronounced endothelial dysfunction than DM patients without DPNP and control subjects. Patients with hyperproduction ofNOx had DM for more than 10 years and their total NDS score was significantly higher than in two other groups. Conclusion. Endothelial dysfunction in children and adolescents with type 1 diabetes mellitus progresses with the development of DPNP. Depletion of endothelialfunctional reserve is responsible for the unfavourable course of DPNP.
format	article
author	A A Afonin M V Komkova G A Galkina N V Morozova
author_facet	A A Afonin M V Komkova G A Galkina N V Morozova
author_sort	A A Afonin
title	Endothelial dysfunction in children and adolescents with type 1 diabetes mellitus and its role in the development of diabetic peripheral polyneuropathy
title_short	Endothelial dysfunction in children and adolescents with type 1 diabetes mellitus and its role in the development of diabetic peripheral polyneuropathy
title_full	Endothelial dysfunction in children and adolescents with type 1 diabetes mellitus and its role in the development of diabetic peripheral polyneuropathy
title_fullStr	Endothelial dysfunction in children and adolescents with type 1 diabetes mellitus and its role in the development of diabetic peripheral polyneuropathy
title_full_unstemmed	Endothelial dysfunction in children and adolescents with type 1 diabetes mellitus and its role in the development of diabetic peripheral polyneuropathy
title_sort	endothelial dysfunction in children and adolescents with type 1 diabetes mellitus and its role in the development of diabetic peripheral polyneuropathy
publisher	Endocrinology Research Centre
publishDate	2009
url	https://doaj.org/article/ce877c0bec314671a0bc3336bfb3e184
work_keys_str_mv	AT aaafonin endothelialdysfunctioninchildrenandadolescentswithtype1diabetesmellitusanditsroleinthedevelopmentofdiabeticperipheralpolyneuropathy AT mvkomkova endothelialdysfunctioninchildrenandadolescentswithtype1diabetesmellitusanditsroleinthedevelopmentofdiabeticperipheralpolyneuropathy AT gagalkina endothelialdysfunctioninchildrenandadolescentswithtype1diabetesmellitusanditsroleinthedevelopmentofdiabeticperipheralpolyneuropathy AT nvmorozova endothelialdysfunctioninchildrenandadolescentswithtype1diabetesmellitusanditsroleinthedevelopmentofdiabeticperipheralpolyneuropathy
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Endothelial dysfunction in children and adolescents with type 1 diabetes mellitus and its role in the development of diabetic peripheral polyneuropathy

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