Acid ceramidase of macrophages traps herpes simplex virus in multivesicular bodies and protects from severe disease
Macrophages are critical in limiting replication of herpes simplex virus type 1 (HSV-1). Here the authors show how acid ceramidase and its enzymatic product sphingosine enable multivesicular bodies to function as an anti-viral mechanism.
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Nature Portfolio
2020
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oai:doaj.org-article:ce87beeac86246829e4b47c4ed971f392021-12-02T14:41:15ZAcid ceramidase of macrophages traps herpes simplex virus in multivesicular bodies and protects from severe disease10.1038/s41467-020-15072-82041-1723https://doaj.org/article/ce87beeac86246829e4b47c4ed971f392020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15072-8https://doaj.org/toc/2041-1723Macrophages are critical in limiting replication of herpes simplex virus type 1 (HSV-1). Here the authors show how acid ceramidase and its enzymatic product sphingosine enable multivesicular bodies to function as an anti-viral mechanism.Judith LangPatrick BohnHilal BhatHolger JastrowBernd WalkenfortFeyza CansizJulian FinkMichael BauerDominik OlszewskiAna Ramos-NascimentoVikas DuhanSarah-Kim FriedrichKatrin Anne BeckerAdalbert KrawczykMichael J. EdwardsAndreas BurchertMagdalena HuberJusta Friebus-KardashJoachim R. GöthertCornelia HardtHans Christian ProbstFabian SchumacherKarl KöhrerBurkhard KleuserEduard B. BabiychukBeate SodeikJürgen SeibelUrs F. GreberPhilipp A. LangErich GulbinsKarl S. LangNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Judith Lang Patrick Bohn Hilal Bhat Holger Jastrow Bernd Walkenfort Feyza Cansiz Julian Fink Michael Bauer Dominik Olszewski Ana Ramos-Nascimento Vikas Duhan Sarah-Kim Friedrich Katrin Anne Becker Adalbert Krawczyk Michael J. Edwards Andreas Burchert Magdalena Huber Justa Friebus-Kardash Joachim R. Göthert Cornelia Hardt Hans Christian Probst Fabian Schumacher Karl Köhrer Burkhard Kleuser Eduard B. Babiychuk Beate Sodeik Jürgen Seibel Urs F. Greber Philipp A. Lang Erich Gulbins Karl S. Lang Acid ceramidase of macrophages traps herpes simplex virus in multivesicular bodies and protects from severe disease |
| description |
Macrophages are critical in limiting replication of herpes simplex virus type 1 (HSV-1). Here the authors show how acid ceramidase and its enzymatic product sphingosine enable multivesicular bodies to function as an anti-viral mechanism. |
| format |
article |
| author |
Judith Lang Patrick Bohn Hilal Bhat Holger Jastrow Bernd Walkenfort Feyza Cansiz Julian Fink Michael Bauer Dominik Olszewski Ana Ramos-Nascimento Vikas Duhan Sarah-Kim Friedrich Katrin Anne Becker Adalbert Krawczyk Michael J. Edwards Andreas Burchert Magdalena Huber Justa Friebus-Kardash Joachim R. Göthert Cornelia Hardt Hans Christian Probst Fabian Schumacher Karl Köhrer Burkhard Kleuser Eduard B. Babiychuk Beate Sodeik Jürgen Seibel Urs F. Greber Philipp A. Lang Erich Gulbins Karl S. Lang |
| author_facet |
Judith Lang Patrick Bohn Hilal Bhat Holger Jastrow Bernd Walkenfort Feyza Cansiz Julian Fink Michael Bauer Dominik Olszewski Ana Ramos-Nascimento Vikas Duhan Sarah-Kim Friedrich Katrin Anne Becker Adalbert Krawczyk Michael J. Edwards Andreas Burchert Magdalena Huber Justa Friebus-Kardash Joachim R. Göthert Cornelia Hardt Hans Christian Probst Fabian Schumacher Karl Köhrer Burkhard Kleuser Eduard B. Babiychuk Beate Sodeik Jürgen Seibel Urs F. Greber Philipp A. Lang Erich Gulbins Karl S. Lang |
| author_sort |
Judith Lang |
| title |
Acid ceramidase of macrophages traps herpes simplex virus in multivesicular bodies and protects from severe disease |
| title_short |
Acid ceramidase of macrophages traps herpes simplex virus in multivesicular bodies and protects from severe disease |
| title_full |
Acid ceramidase of macrophages traps herpes simplex virus in multivesicular bodies and protects from severe disease |
| title_fullStr |
Acid ceramidase of macrophages traps herpes simplex virus in multivesicular bodies and protects from severe disease |
| title_full_unstemmed |
Acid ceramidase of macrophages traps herpes simplex virus in multivesicular bodies and protects from severe disease |
| title_sort |
acid ceramidase of macrophages traps herpes simplex virus in multivesicular bodies and protects from severe disease |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/ce87beeac86246829e4b47c4ed971f39 |
| work_keys_str_mv |
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