Profound olfactory dysfunction in myasthenia gravis.

In this study we demonstrate that myasthenia gravis, an autoimmune disease strongly identified with deficient acetylcholine receptor transmission at the post-synaptic neuromuscular junction, is accompanied by a profound loss of olfactory function. Twenty-seven MG patients, 27 matched healthy control...

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Autores principales:	Fidias E Leon-Sarmiento, Edgardo A Bayona, Jaime Bayona-Prieto, Allen Osman, Richard L Doty
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ce8823ac87ae48ccbc3b26199f484d34
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spelling	oai:doaj.org-article:ce8823ac87ae48ccbc3b26199f484d342021-11-18T08:11:46ZProfound olfactory dysfunction in myasthenia gravis.1932-620310.1371/journal.pone.0045544https://doaj.org/article/ce8823ac87ae48ccbc3b26199f484d342012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23082113/?tool=EBIhttps://doaj.org/toc/1932-6203In this study we demonstrate that myasthenia gravis, an autoimmune disease strongly identified with deficient acetylcholine receptor transmission at the post-synaptic neuromuscular junction, is accompanied by a profound loss of olfactory function. Twenty-seven MG patients, 27 matched healthy controls, and 11 patients with polymiositis, a disease with peripheral neuromuscular symptoms analogous to myasthenia gravis with no known central nervous system involvement, were tested. All were administered the University of Pennsylvania Smell Identification Test (UPSIT) and the Picture Identification Test (PIT), a test analogous in content and form to the UPSIT designed to control for non-olfactory cognitive confounds. The UPSIT scores of the myasthenia gravis patients were markedly lower than those of the age- and sex-matched normal controls [respective means (SDs) =20.15 (6.40) & 35.67 (4.95); p<0.0001], as well as those of the polymiositis patients who scored slightly below the normal range [33.30 (1.42); p<0.0001]. The latter finding, along with direct monitoring of the inhalation of the patients during testing, implies that the MG-related olfactory deficit is unlikely due to difficulties sniffing, per se. All PIT scores were within or near the normal range, although subtle deficits were apparent in both the MG and PM patients, conceivably reflecting influences of mild cognitive impairment. No relationships between performance on the UPSIT and thymectomy, time since diagnosis, type of treatment regimen, or the presence or absence of serum anti-nicotinic or muscarinic antibodies were apparent. Our findings suggest that MG influences olfactory function to the same degree as observed in a number of neurodegenerative diseases in which central nervous system cholinergic dysfunction has been documented.Fidias E Leon-SarmientoEdgardo A BayonaJaime Bayona-PrietoAllen OsmanRichard L DotyPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 10, p e45544 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Fidias E Leon-Sarmiento Edgardo A Bayona Jaime Bayona-Prieto Allen Osman Richard L Doty Profound olfactory dysfunction in myasthenia gravis.
description	In this study we demonstrate that myasthenia gravis, an autoimmune disease strongly identified with deficient acetylcholine receptor transmission at the post-synaptic neuromuscular junction, is accompanied by a profound loss of olfactory function. Twenty-seven MG patients, 27 matched healthy controls, and 11 patients with polymiositis, a disease with peripheral neuromuscular symptoms analogous to myasthenia gravis with no known central nervous system involvement, were tested. All were administered the University of Pennsylvania Smell Identification Test (UPSIT) and the Picture Identification Test (PIT), a test analogous in content and form to the UPSIT designed to control for non-olfactory cognitive confounds. The UPSIT scores of the myasthenia gravis patients were markedly lower than those of the age- and sex-matched normal controls [respective means (SDs) =20.15 (6.40) & 35.67 (4.95); p<0.0001], as well as those of the polymiositis patients who scored slightly below the normal range [33.30 (1.42); p<0.0001]. The latter finding, along with direct monitoring of the inhalation of the patients during testing, implies that the MG-related olfactory deficit is unlikely due to difficulties sniffing, per se. All PIT scores were within or near the normal range, although subtle deficits were apparent in both the MG and PM patients, conceivably reflecting influences of mild cognitive impairment. No relationships between performance on the UPSIT and thymectomy, time since diagnosis, type of treatment regimen, or the presence or absence of serum anti-nicotinic or muscarinic antibodies were apparent. Our findings suggest that MG influences olfactory function to the same degree as observed in a number of neurodegenerative diseases in which central nervous system cholinergic dysfunction has been documented.
format	article
author	Fidias E Leon-Sarmiento Edgardo A Bayona Jaime Bayona-Prieto Allen Osman Richard L Doty
author_facet	Fidias E Leon-Sarmiento Edgardo A Bayona Jaime Bayona-Prieto Allen Osman Richard L Doty
author_sort	Fidias E Leon-Sarmiento
title	Profound olfactory dysfunction in myasthenia gravis.
title_short	Profound olfactory dysfunction in myasthenia gravis.
title_full	Profound olfactory dysfunction in myasthenia gravis.
title_fullStr	Profound olfactory dysfunction in myasthenia gravis.
title_full_unstemmed	Profound olfactory dysfunction in myasthenia gravis.
title_sort	profound olfactory dysfunction in myasthenia gravis.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/ce8823ac87ae48ccbc3b26199f484d34
work_keys_str_mv	AT fidiaseleonsarmiento profoundolfactorydysfunctioninmyastheniagravis AT edgardoabayona profoundolfactorydysfunctioninmyastheniagravis AT jaimebayonaprieto profoundolfactorydysfunctioninmyastheniagravis AT allenosman profoundolfactorydysfunctioninmyastheniagravis AT richardldoty profoundolfactorydysfunctioninmyastheniagravis
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Profound olfactory dysfunction in myasthenia gravis.

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