Patient-derived lung cancer organoids as in vitro cancer models for therapeutic screening

The clinical efficacy of standard therapy in lung cancer is limited by high level of heterogeneity. Here, the authors report patient-derived lung cancer organoids from different histological subtypes and show them to faithfully recapitulate the histology, genomics, and drug responses of the primary...

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Autores principales:	Minsuh Kim, Hyemin Mun, Chang Oak Sung, Eun Jeong Cho, Hye-Joon Jeon, Sung-Min Chun, Da Jung Jung, Tae Hoon Shin, Gi Seok Jeong, Dong Kwan Kim, Eun Kyung Choi, Seong-Yun Jeong, Alison M. Taylor, Sejal Jain, Matthew Meyerson, Se Jin Jang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ce888df5d1284e7192c86d55942e13a0
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:ce888df5d1284e7192c86d55942e13a02021-12-02T15:35:35ZPatient-derived lung cancer organoids as in vitro cancer models for therapeutic screening10.1038/s41467-019-11867-62041-1723https://doaj.org/article/ce888df5d1284e7192c86d55942e13a02019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11867-6https://doaj.org/toc/2041-1723The clinical efficacy of standard therapy in lung cancer is limited by high level of heterogeneity. Here, the authors report patient-derived lung cancer organoids from different histological subtypes and show them to faithfully recapitulate the histology, genomics, and drug responses of the primary lung tumours.Minsuh KimHyemin MunChang Oak SungEun Jeong ChoHye-Joon JeonSung-Min ChunDa Jung JungTae Hoon ShinGi Seok JeongDong Kwan KimEun Kyung ChoiSeong-Yun JeongAlison M. TaylorSejal JainMatthew MeyersonSe Jin JangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Minsuh Kim Hyemin Mun Chang Oak Sung Eun Jeong Cho Hye-Joon Jeon Sung-Min Chun Da Jung Jung Tae Hoon Shin Gi Seok Jeong Dong Kwan Kim Eun Kyung Choi Seong-Yun Jeong Alison M. Taylor Sejal Jain Matthew Meyerson Se Jin Jang Patient-derived lung cancer organoids as in vitro cancer models for therapeutic screening
description	The clinical efficacy of standard therapy in lung cancer is limited by high level of heterogeneity. Here, the authors report patient-derived lung cancer organoids from different histological subtypes and show them to faithfully recapitulate the histology, genomics, and drug responses of the primary lung tumours.
format	article
author	Minsuh Kim Hyemin Mun Chang Oak Sung Eun Jeong Cho Hye-Joon Jeon Sung-Min Chun Da Jung Jung Tae Hoon Shin Gi Seok Jeong Dong Kwan Kim Eun Kyung Choi Seong-Yun Jeong Alison M. Taylor Sejal Jain Matthew Meyerson Se Jin Jang
author_facet	Minsuh Kim Hyemin Mun Chang Oak Sung Eun Jeong Cho Hye-Joon Jeon Sung-Min Chun Da Jung Jung Tae Hoon Shin Gi Seok Jeong Dong Kwan Kim Eun Kyung Choi Seong-Yun Jeong Alison M. Taylor Sejal Jain Matthew Meyerson Se Jin Jang
author_sort	Minsuh Kim
title	Patient-derived lung cancer organoids as in vitro cancer models for therapeutic screening
title_short	Patient-derived lung cancer organoids as in vitro cancer models for therapeutic screening
title_full	Patient-derived lung cancer organoids as in vitro cancer models for therapeutic screening
title_fullStr	Patient-derived lung cancer organoids as in vitro cancer models for therapeutic screening
title_full_unstemmed	Patient-derived lung cancer organoids as in vitro cancer models for therapeutic screening
title_sort	patient-derived lung cancer organoids as in vitro cancer models for therapeutic screening
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/ce888df5d1284e7192c86d55942e13a0
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Patient-derived lung cancer organoids as in vitro cancer models for therapeutic screening

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