Optimization of Hydroxy Propyl Methyl Cellulose and Carbomer In Diltiazem Hydrochloride Mucoadhesive Buccal Film

Diltiazem hydrochloride (HCl) is a category of calcium channel blocker used as an antihypertensive agent. Diltiazem HCl is a low bioavailable drug due to high first-pass metabolism and a short half-life (3-5 hours); hence mucoadhesive buccal film was made to overcome this weakness. Bioavailability o...

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Autores principales:	Lina Winarti, Bagus Tri Laksono, Lusia Oktora Ruma Kumala Sari
Formato:	article
Lenguaje:	EN
Publicado:	Universitas Gadjah Mada 2021
Materias:	diltiazem hcl hpmc carbomer mucoadhesive buccal film Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/ce890bae53764b069f052f2b421507c4
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spelling	oai:doaj.org-article:ce890bae53764b069f052f2b421507c42021-11-15T06:08:47ZOptimization of Hydroxy Propyl Methyl Cellulose and Carbomer In Diltiazem Hydrochloride Mucoadhesive Buccal Film2338-94272338-948610.22146/ijp.995https://doaj.org/article/ce890bae53764b069f052f2b421507c42021-01-01T00:00:00Zhttps://jurnal.ugm.ac.id/v3/IJP/article/view/995https://doaj.org/toc/2338-9427https://doaj.org/toc/2338-9486Diltiazem hydrochloride (HCl) is a category of calcium channel blocker used as an antihypertensive agent. Diltiazem HCl is a low bioavailable drug due to high first-pass metabolism and a short half-life (3-5 hours); hence mucoadhesive buccal film was made to overcome this weakness. Bioavailability of Diltiazem HCl increase if the buccal preparations can contact the mucosa for a sufficient time. Therefore, in this study, two polymers are combined to obtain good film characteristics, especially residence time and mucoadhesive strength. This study was aimed to optimize Hydroxy Propyl Methyl Cellulose (HPMC) and Carbomer's amount in Diltiazem HCl mucoadhesive buccal film. The formulas were prepared by the solvent casting method and optimized with design expert software. The release kinetics and mechanism were evaluated using DDSolver program. The optimum amount of polymer obtained from optimization was 40 mg of HPMC and 10 mg of Carbomer. The optimum formula's swelling index was 4.18. The mucoadhesive strength was 53.07 gF, and the mucoadhesive residence time was 529.33 min. The FTIR spectra showed there was no interaction between Diltiazem HCl and other excipients. Thus it did not disturb the therapeutic effect. Based on the DDSolver statistical parameters and curve-fitting, the dissolution model of Diltiazem HCl from buccal mucoadhesive film follows Korsmeyer-Peppas. The release exponent (n) is 0.55, which shows a non-fickian/anomalous diffusion release mechanism. These mechanisms represent drug release controlled by a combination of diffusion and erosion.Lina WinartiBagus Tri LaksonoLusia Oktora Ruma Kumala SariUniversitas Gadjah Madaarticlediltiazem hclhpmccarbomermucoadhesive buccal filmPharmacy and materia medicaRS1-441ENIndonesian Journal of Pharmacy, Pp 43-51 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	diltiazem hcl hpmc carbomer mucoadhesive buccal film Pharmacy and materia medica RS1-441
spellingShingle	diltiazem hcl hpmc carbomer mucoadhesive buccal film Pharmacy and materia medica RS1-441 Lina Winarti Bagus Tri Laksono Lusia Oktora Ruma Kumala Sari Optimization of Hydroxy Propyl Methyl Cellulose and Carbomer In Diltiazem Hydrochloride Mucoadhesive Buccal Film
description	Diltiazem hydrochloride (HCl) is a category of calcium channel blocker used as an antihypertensive agent. Diltiazem HCl is a low bioavailable drug due to high first-pass metabolism and a short half-life (3-5 hours); hence mucoadhesive buccal film was made to overcome this weakness. Bioavailability of Diltiazem HCl increase if the buccal preparations can contact the mucosa for a sufficient time. Therefore, in this study, two polymers are combined to obtain good film characteristics, especially residence time and mucoadhesive strength. This study was aimed to optimize Hydroxy Propyl Methyl Cellulose (HPMC) and Carbomer's amount in Diltiazem HCl mucoadhesive buccal film. The formulas were prepared by the solvent casting method and optimized with design expert software. The release kinetics and mechanism were evaluated using DDSolver program. The optimum amount of polymer obtained from optimization was 40 mg of HPMC and 10 mg of Carbomer. The optimum formula's swelling index was 4.18. The mucoadhesive strength was 53.07 gF, and the mucoadhesive residence time was 529.33 min. The FTIR spectra showed there was no interaction between Diltiazem HCl and other excipients. Thus it did not disturb the therapeutic effect. Based on the DDSolver statistical parameters and curve-fitting, the dissolution model of Diltiazem HCl from buccal mucoadhesive film follows Korsmeyer-Peppas. The release exponent (n) is 0.55, which shows a non-fickian/anomalous diffusion release mechanism. These mechanisms represent drug release controlled by a combination of diffusion and erosion.
format	article
author	Lina Winarti Bagus Tri Laksono Lusia Oktora Ruma Kumala Sari
author_facet	Lina Winarti Bagus Tri Laksono Lusia Oktora Ruma Kumala Sari
author_sort	Lina Winarti
title	Optimization of Hydroxy Propyl Methyl Cellulose and Carbomer In Diltiazem Hydrochloride Mucoadhesive Buccal Film
title_short	Optimization of Hydroxy Propyl Methyl Cellulose and Carbomer In Diltiazem Hydrochloride Mucoadhesive Buccal Film
title_full	Optimization of Hydroxy Propyl Methyl Cellulose and Carbomer In Diltiazem Hydrochloride Mucoadhesive Buccal Film
title_fullStr	Optimization of Hydroxy Propyl Methyl Cellulose and Carbomer In Diltiazem Hydrochloride Mucoadhesive Buccal Film
title_full_unstemmed	Optimization of Hydroxy Propyl Methyl Cellulose and Carbomer In Diltiazem Hydrochloride Mucoadhesive Buccal Film
title_sort	optimization of hydroxy propyl methyl cellulose and carbomer in diltiazem hydrochloride mucoadhesive buccal film
publisher	Universitas Gadjah Mada
publishDate	2021
url	https://doaj.org/article/ce890bae53764b069f052f2b421507c4
work_keys_str_mv	AT linawinarti optimizationofhydroxypropylmethylcelluloseandcarbomerindiltiazemhydrochloridemucoadhesivebuccalfilm AT bagustrilaksono optimizationofhydroxypropylmethylcelluloseandcarbomerindiltiazemhydrochloridemucoadhesivebuccalfilm AT lusiaoktorarumakumalasari optimizationofhydroxypropylmethylcelluloseandcarbomerindiltiazemhydrochloridemucoadhesivebuccalfilm
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Optimization of Hydroxy Propyl Methyl Cellulose and Carbomer In Diltiazem Hydrochloride Mucoadhesive Buccal Film

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