Uncovering the pharmacological mechanism of the effects of the Banxia-Xiakucao Chinese Herb Pair on sleep disorder by a systems pharmacology approach

Abstract Sleep disorder (SD) has a high incidence and seriously affects quality of life, mental health and even the manifestation of physical diseases. The combination of Pinellia ternata (Chinese name: banxia) and Prunella vulgaris (Chinese name: xiakucao), known as the Banxia–Xiakucao Chinese herb...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jing Guo, Meng-Ping Lou, Lin-Lin Hu, Xin Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ce897ea2f3ca49398b57cda45a26ce5b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ce897ea2f3ca49398b57cda45a26ce5b
record_format	dspace
spelling	oai:doaj.org-article:ce897ea2f3ca49398b57cda45a26ce5b2021-12-02T11:42:15ZUncovering the pharmacological mechanism of the effects of the Banxia-Xiakucao Chinese Herb Pair on sleep disorder by a systems pharmacology approach10.1038/s41598-020-77431-12045-2322https://doaj.org/article/ce897ea2f3ca49398b57cda45a26ce5b2020-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-77431-1https://doaj.org/toc/2045-2322Abstract Sleep disorder (SD) has a high incidence and seriously affects quality of life, mental health and even the manifestation of physical diseases. The combination of Pinellia ternata (Chinese name: banxia) and Prunella vulgaris (Chinese name: xiakucao), known as the Banxia–Xiakucao Chinese herb pair (BXHP), is a proven Chinese herbal medicine that has been used to treat SD for thousands of years due to its significant clinical effects. However, its active pharmacological components and sedative–hypnotic mechanisms have not been fully elucidated. Thus, the present study used a systematic pharmacological approach to develop pharmacokinetic screens and target predictions via construction of a protein–protein interaction network and annotation database for SD-related and putative BXHP-related targets. Visualization, screening and integrated discovery enrichment analyses were conducted. The BXHP chemical database contains 166 compounds between the two herbal ingredients, and of these, 22 potential active molecules were screened by pharmacokinetic evaluation. The targets of 114 of the active molecules were predicted, and 34 were selected for further analysis. Finally, gene ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses suggested that BXHP can reduce inflammatory responses. and mediate immune-related and central nervous system neurotransmitters via regulation of multiple targets and pathways. The use of a systematic pharmacology-based approach in the present study further elucidated the mechanisms of action underlying BXHP for the treatment of SD from a holistic perspective and sheds light on the systemic mechanisms of action of Chinese herbal medicines in general.Jing GuoMeng-Ping LouLin-Lin HuXin ZhangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jing Guo Meng-Ping Lou Lin-Lin Hu Xin Zhang Uncovering the pharmacological mechanism of the effects of the Banxia-Xiakucao Chinese Herb Pair on sleep disorder by a systems pharmacology approach
description	Abstract Sleep disorder (SD) has a high incidence and seriously affects quality of life, mental health and even the manifestation of physical diseases. The combination of Pinellia ternata (Chinese name: banxia) and Prunella vulgaris (Chinese name: xiakucao), known as the Banxia–Xiakucao Chinese herb pair (BXHP), is a proven Chinese herbal medicine that has been used to treat SD for thousands of years due to its significant clinical effects. However, its active pharmacological components and sedative–hypnotic mechanisms have not been fully elucidated. Thus, the present study used a systematic pharmacological approach to develop pharmacokinetic screens and target predictions via construction of a protein–protein interaction network and annotation database for SD-related and putative BXHP-related targets. Visualization, screening and integrated discovery enrichment analyses were conducted. The BXHP chemical database contains 166 compounds between the two herbal ingredients, and of these, 22 potential active molecules were screened by pharmacokinetic evaluation. The targets of 114 of the active molecules were predicted, and 34 were selected for further analysis. Finally, gene ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses suggested that BXHP can reduce inflammatory responses. and mediate immune-related and central nervous system neurotransmitters via regulation of multiple targets and pathways. The use of a systematic pharmacology-based approach in the present study further elucidated the mechanisms of action underlying BXHP for the treatment of SD from a holistic perspective and sheds light on the systemic mechanisms of action of Chinese herbal medicines in general.
format	article
author	Jing Guo Meng-Ping Lou Lin-Lin Hu Xin Zhang
author_facet	Jing Guo Meng-Ping Lou Lin-Lin Hu Xin Zhang
author_sort	Jing Guo
title	Uncovering the pharmacological mechanism of the effects of the Banxia-Xiakucao Chinese Herb Pair on sleep disorder by a systems pharmacology approach
title_short	Uncovering the pharmacological mechanism of the effects of the Banxia-Xiakucao Chinese Herb Pair on sleep disorder by a systems pharmacology approach
title_full	Uncovering the pharmacological mechanism of the effects of the Banxia-Xiakucao Chinese Herb Pair on sleep disorder by a systems pharmacology approach
title_fullStr	Uncovering the pharmacological mechanism of the effects of the Banxia-Xiakucao Chinese Herb Pair on sleep disorder by a systems pharmacology approach
title_full_unstemmed	Uncovering the pharmacological mechanism of the effects of the Banxia-Xiakucao Chinese Herb Pair on sleep disorder by a systems pharmacology approach
title_sort	uncovering the pharmacological mechanism of the effects of the banxia-xiakucao chinese herb pair on sleep disorder by a systems pharmacology approach
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/ce897ea2f3ca49398b57cda45a26ce5b
work_keys_str_mv	AT jingguo uncoveringthepharmacologicalmechanismoftheeffectsofthebanxiaxiakucaochineseherbpaironsleepdisorderbyasystemspharmacologyapproach AT mengpinglou uncoveringthepharmacologicalmechanismoftheeffectsofthebanxiaxiakucaochineseherbpaironsleepdisorderbyasystemspharmacologyapproach AT linlinhu uncoveringthepharmacologicalmechanismoftheeffectsofthebanxiaxiakucaochineseherbpaironsleepdisorderbyasystemspharmacologyapproach AT xinzhang uncoveringthepharmacologicalmechanismoftheeffectsofthebanxiaxiakucaochineseherbpaironsleepdisorderbyasystemspharmacologyapproach
_version_	1718395370703159296

Uncovering the pharmacological mechanism of the effects of the Banxia-Xiakucao Chinese Herb Pair on sleep disorder by a systems pharmacology approach

Ejemplares similares