Optic disc topography in Malay patients with normal-tension glaucoma and primary open-angle glaucoma

Abdul Rahim Adlina,1,2 Koh Alisa-Victoria,1 Ismail Shatriah,1 Ahmad Tajudin Liza-Sharmini,1 Mt Saad Ahmad2 1Department of Ophthalmology, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia; 2Department of Ophthalmology, Hospital Sultanah Bahiy...

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Autores principales:	Adlina AR, Alisa-Victoria K, Shatriah I, Liza-Sharmini AT, Ahmad MS
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/ce8ec8b236934c938443bb55ed0f81b6
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spelling	oai:doaj.org-article:ce8ec8b236934c938443bb55ed0f81b62021-12-02T01:30:34ZOptic disc topography in Malay patients with normal-tension glaucoma and primary open-angle glaucoma1177-5483https://doaj.org/article/ce8ec8b236934c938443bb55ed0f81b62014-12-01T00:00:00Zhttp://www.dovepress.com/optic-disc-topography-in-malay-patients-with-normal-tension-glaucoma-a-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483 Abdul Rahim Adlina,1,2 Koh Alisa-Victoria,1 Ismail Shatriah,1 Ahmad Tajudin Liza-Sharmini,1 Mt Saad Ahmad2 1Department of Ophthalmology, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia; 2Department of Ophthalmology, Hospital Sultanah Bahiyah, Alor Setar, Kedah, Malaysia Background: There are limited data concerning the optic disc topography in normal-tension glaucoma (NTG) and primary open-angle glaucoma (POAG) patients living in Southeast Asian countries. This study aims to compare optic disc parameters in patients with NTG and POAG in Malaysia and to discuss the results in comparison with studies of NTG and POAG in other Asian countries.Methods: This prospective cross-sectional study was performed in two hospitals with glaucoma service in Malaysia from 2010 to 2012. Seventy-seven patients of Malay ethnicity were enrolled in this study, including 32 NTG patients and 45 POAG patients. Using the Heidelberg Retinal Tomograph III, we measured optic disc area, cup area, rim area, cup volume, rim volume, cup-to-disc area ratio, mean cup depth, maximum cup depth, cup shape measure, height variation contour, mean retinal nerve fiber layer thickness, and retinal nerve fiber layer cross-sectional area. Results: The eyes for NTG patients had significantly larger optic disc areas (2.65 [standard deviation, 0.41] vs 2.40 [standard deviation, 0.36] mm², respectively; P=0.006) and cup areas (1.54 [standard deviation, 0.43] vs 1.32 [standard deviation, 0.40] mm², respectively; P=0.027) compared with the eyes of POAG patients. Comparison of the other parameters between the two groups revealed no significant difference (P>0.050). The moderate and severe NTG patients showed significantly deeper cups and larger disc and cup areas when compared with the moderate and severe POAG patients (P<0.050).Conclusion: The NTG patients in this study have notably larger optic disc and cup areas than the POAG patients. Our observations are consistent with those reported in studies of NTG and POAG patients in Korea. The deeper cups and larger disc and cup areas may serve as indicators of severity when comparing NTG with POAG. However, these findings require verification with IOP and visual field results. Keywords: normal-tension glaucoma, primary open-angle glaucoma, Malay ethnicity, optic disc topography, Heidelberg Retina Topography IIIAdlina ARAlisa-Victoria KShatriah ILiza-Sharmini ATAhmad MSDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2014, Iss default, Pp 2533-2539 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Adlina AR Alisa-Victoria K Shatriah I Liza-Sharmini AT Ahmad MS Optic disc topography in Malay patients with normal-tension glaucoma and primary open-angle glaucoma
description	Abdul Rahim Adlina,1,2 Koh Alisa-Victoria,1 Ismail Shatriah,1 Ahmad Tajudin Liza-Sharmini,1 Mt Saad Ahmad2 1Department of Ophthalmology, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia; 2Department of Ophthalmology, Hospital Sultanah Bahiyah, Alor Setar, Kedah, Malaysia Background: There are limited data concerning the optic disc topography in normal-tension glaucoma (NTG) and primary open-angle glaucoma (POAG) patients living in Southeast Asian countries. This study aims to compare optic disc parameters in patients with NTG and POAG in Malaysia and to discuss the results in comparison with studies of NTG and POAG in other Asian countries.Methods: This prospective cross-sectional study was performed in two hospitals with glaucoma service in Malaysia from 2010 to 2012. Seventy-seven patients of Malay ethnicity were enrolled in this study, including 32 NTG patients and 45 POAG patients. Using the Heidelberg Retinal Tomograph III, we measured optic disc area, cup area, rim area, cup volume, rim volume, cup-to-disc area ratio, mean cup depth, maximum cup depth, cup shape measure, height variation contour, mean retinal nerve fiber layer thickness, and retinal nerve fiber layer cross-sectional area. Results: The eyes for NTG patients had significantly larger optic disc areas (2.65 [standard deviation, 0.41] vs 2.40 [standard deviation, 0.36] mm², respectively; P=0.006) and cup areas (1.54 [standard deviation, 0.43] vs 1.32 [standard deviation, 0.40] mm², respectively; P=0.027) compared with the eyes of POAG patients. Comparison of the other parameters between the two groups revealed no significant difference (P>0.050). The moderate and severe NTG patients showed significantly deeper cups and larger disc and cup areas when compared with the moderate and severe POAG patients (P<0.050).Conclusion: The NTG patients in this study have notably larger optic disc and cup areas than the POAG patients. Our observations are consistent with those reported in studies of NTG and POAG patients in Korea. The deeper cups and larger disc and cup areas may serve as indicators of severity when comparing NTG with POAG. However, these findings require verification with IOP and visual field results. Keywords: normal-tension glaucoma, primary open-angle glaucoma, Malay ethnicity, optic disc topography, Heidelberg Retina Topography III
format	article
author	Adlina AR Alisa-Victoria K Shatriah I Liza-Sharmini AT Ahmad MS
author_facet	Adlina AR Alisa-Victoria K Shatriah I Liza-Sharmini AT Ahmad MS
author_sort	Adlina AR
title	Optic disc topography in Malay patients with normal-tension glaucoma and primary open-angle glaucoma
title_short	Optic disc topography in Malay patients with normal-tension glaucoma and primary open-angle glaucoma
title_full	Optic disc topography in Malay patients with normal-tension glaucoma and primary open-angle glaucoma
title_fullStr	Optic disc topography in Malay patients with normal-tension glaucoma and primary open-angle glaucoma
title_full_unstemmed	Optic disc topography in Malay patients with normal-tension glaucoma and primary open-angle glaucoma
title_sort	optic disc topography in malay patients with normal-tension glaucoma and primary open-angle glaucoma
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/ce8ec8b236934c938443bb55ed0f81b6
work_keys_str_mv	AT adlinaar opticdisctopographyinmalaypatientswithnormaltensionglaucomaandprimaryopenangleglaucoma AT alisavictoriak opticdisctopographyinmalaypatientswithnormaltensionglaucomaandprimaryopenangleglaucoma AT shatriahi opticdisctopographyinmalaypatientswithnormaltensionglaucomaandprimaryopenangleglaucoma AT lizasharminiat opticdisctopographyinmalaypatientswithnormaltensionglaucomaandprimaryopenangleglaucoma AT ahmadms opticdisctopographyinmalaypatientswithnormaltensionglaucomaandprimaryopenangleglaucoma
_version_	1718403041572421632

Optic disc topography in Malay patients with normal-tension glaucoma and primary open-angle glaucoma

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