Preparation of a novel Mixed-Ligand divalent metal complexes from solvent free Synthesized Schiff base derived from 2,6-Diaminopyridine with cinnamaldehyde and 2,2′‐Bipyridine: Characterization and antibacterial activities

The solvent-free conditions were employed to synthesise symmetrical Schiff base ligand from 2,6-diaminopyridine with cinnamaldehyde in (1 min) with a fair yield utilizing formic acid as a catalyst. Through coordination chemistry, new heteroleptic complexes of Cu(II), Co(II), Ni(II), Pt(II), Pd(II) a...

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Autores principales:	Diary I. Tofiq, Hanar Q. Hassan, Karzan A. Abdalkarim
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Mixed-ligand complexes 2,2′‐bipyridine Transition metals Schiff base Biological activity Free-solvent condition Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/ce8f22ab7a964a548eb5480c86181599
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spelling	oai:doaj.org-article:ce8f22ab7a964a548eb5480c861815992021-11-20T04:57:52ZPreparation of a novel Mixed-Ligand divalent metal complexes from solvent free Synthesized Schiff base derived from 2,6-Diaminopyridine with cinnamaldehyde and 2,2′‐Bipyridine: Characterization and antibacterial activities1878-535210.1016/j.arabjc.2021.103429https://doaj.org/article/ce8f22ab7a964a548eb5480c861815992021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1878535221004445https://doaj.org/toc/1878-5352The solvent-free conditions were employed to synthesise symmetrical Schiff base ligand from 2,6-diaminopyridine with cinnamaldehyde in (1 min) with a fair yield utilizing formic acid as a catalyst. Through coordination chemistry, new heteroleptic complexes of Cu(II), Co(II), Ni(II), Pt(II), Pd(II) and Zn(II) were achieved from Schiff base as a primary chelator (L1) and 2,2′‐bipyridine (2,2′-bipy) as a secondary chelator (L2). The prepared compounds have been characterized by elemental analysis, molar conductivity, magnetic susceptibility, FTIR, 1H NMR, UV–visible, mass spectrometry, and thermal gravimetric analysis, and screened in vitro for their potential as antibacterial activity by the agar well diffusion method. The metal complexes were formulated as [M (L1) (L2) (X)] Y⋅nH2O, L1 = Schiff base, L2 = 2,2′-bipy, (M = Cu(II), Co(II), Zn(II), Y = 2NO3, n = 1), (M = Ni(II), X = 2H2O, Y = 2NO3, n = 0) and (M = Pd(II) Pt(II), Y = 2Cl, n = 0). Both L1 and L2 act as a neutral bidentate ligand and coordinates via nitrogen atoms of imine and 2,2′-bipy to metal ions. The metal complexes were found to be electrolytic, with square-planar heteroleptic Cu(II), Co(II), Pt(II), and Pd(II) chelates and octahedral Ni(II) complex. As well as tetrahedral geometry, has been proposed for the complex of Zn(II). Furthermore, the biological activity study revealed that some metal chelates have excellent activity than Schiff base when tested against Gram-negative and Gram-positive strains of Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). Finally, it was found that the Zn(II) and Pd(II) complexes were more effective against both types of bacteria tested than the imine and other metal complexes.Diary I. TofiqHanar Q. HassanKarzan A. AbdalkarimElsevierarticleMixed-ligand complexes2,2′‐bipyridineTransition metalsSchiff baseBiological activityFree-solvent conditionChemistryQD1-999ENArabian Journal of Chemistry, Vol 14, Iss 12, Pp 103429- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Mixed-ligand complexes 2,2′‐bipyridine Transition metals Schiff base Biological activity Free-solvent condition Chemistry QD1-999
spellingShingle	Mixed-ligand complexes 2,2′‐bipyridine Transition metals Schiff base Biological activity Free-solvent condition Chemistry QD1-999 Diary I. Tofiq Hanar Q. Hassan Karzan A. Abdalkarim Preparation of a novel Mixed-Ligand divalent metal complexes from solvent free Synthesized Schiff base derived from 2,6-Diaminopyridine with cinnamaldehyde and 2,2′‐Bipyridine: Characterization and antibacterial activities
description	The solvent-free conditions were employed to synthesise symmetrical Schiff base ligand from 2,6-diaminopyridine with cinnamaldehyde in (1 min) with a fair yield utilizing formic acid as a catalyst. Through coordination chemistry, new heteroleptic complexes of Cu(II), Co(II), Ni(II), Pt(II), Pd(II) and Zn(II) were achieved from Schiff base as a primary chelator (L1) and 2,2′‐bipyridine (2,2′-bipy) as a secondary chelator (L2). The prepared compounds have been characterized by elemental analysis, molar conductivity, magnetic susceptibility, FTIR, 1H NMR, UV–visible, mass spectrometry, and thermal gravimetric analysis, and screened in vitro for their potential as antibacterial activity by the agar well diffusion method. The metal complexes were formulated as [M (L1) (L2) (X)] Y⋅nH2O, L1 = Schiff base, L2 = 2,2′-bipy, (M = Cu(II), Co(II), Zn(II), Y = 2NO3, n = 1), (M = Ni(II), X = 2H2O, Y = 2NO3, n = 0) and (M = Pd(II) Pt(II), Y = 2Cl, n = 0). Both L1 and L2 act as a neutral bidentate ligand and coordinates via nitrogen atoms of imine and 2,2′-bipy to metal ions. The metal complexes were found to be electrolytic, with square-planar heteroleptic Cu(II), Co(II), Pt(II), and Pd(II) chelates and octahedral Ni(II) complex. As well as tetrahedral geometry, has been proposed for the complex of Zn(II). Furthermore, the biological activity study revealed that some metal chelates have excellent activity than Schiff base when tested against Gram-negative and Gram-positive strains of Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). Finally, it was found that the Zn(II) and Pd(II) complexes were more effective against both types of bacteria tested than the imine and other metal complexes.
format	article
author	Diary I. Tofiq Hanar Q. Hassan Karzan A. Abdalkarim
author_facet	Diary I. Tofiq Hanar Q. Hassan Karzan A. Abdalkarim
author_sort	Diary I. Tofiq
title	Preparation of a novel Mixed-Ligand divalent metal complexes from solvent free Synthesized Schiff base derived from 2,6-Diaminopyridine with cinnamaldehyde and 2,2′‐Bipyridine: Characterization and antibacterial activities
title_short	Preparation of a novel Mixed-Ligand divalent metal complexes from solvent free Synthesized Schiff base derived from 2,6-Diaminopyridine with cinnamaldehyde and 2,2′‐Bipyridine: Characterization and antibacterial activities
title_full	Preparation of a novel Mixed-Ligand divalent metal complexes from solvent free Synthesized Schiff base derived from 2,6-Diaminopyridine with cinnamaldehyde and 2,2′‐Bipyridine: Characterization and antibacterial activities
title_fullStr	Preparation of a novel Mixed-Ligand divalent metal complexes from solvent free Synthesized Schiff base derived from 2,6-Diaminopyridine with cinnamaldehyde and 2,2′‐Bipyridine: Characterization and antibacterial activities
title_full_unstemmed	Preparation of a novel Mixed-Ligand divalent metal complexes from solvent free Synthesized Schiff base derived from 2,6-Diaminopyridine with cinnamaldehyde and 2,2′‐Bipyridine: Characterization and antibacterial activities
title_sort	preparation of a novel mixed-ligand divalent metal complexes from solvent free synthesized schiff base derived from 2,6-diaminopyridine with cinnamaldehyde and 2,2′‐bipyridine: characterization and antibacterial activities
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/ce8f22ab7a964a548eb5480c86181599
work_keys_str_mv	AT diaryitofiq preparationofanovelmixedliganddivalentmetalcomplexesfromsolventfreesynthesizedschiffbasederivedfrom26diaminopyridinewithcinnamaldehydeand22bipyridinecharacterizationandantibacterialactivities AT hanarqhassan preparationofanovelmixedliganddivalentmetalcomplexesfromsolventfreesynthesizedschiffbasederivedfrom26diaminopyridinewithcinnamaldehydeand22bipyridinecharacterizationandantibacterialactivities AT karzanaabdalkarim preparationofanovelmixedliganddivalentmetalcomplexesfromsolventfreesynthesizedschiffbasederivedfrom26diaminopyridinewithcinnamaldehydeand22bipyridinecharacterizationandantibacterialactivities
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Preparation of a novel Mixed-Ligand divalent metal complexes from solvent free Synthesized Schiff base derived from 2,6-Diaminopyridine with cinnamaldehyde and 2,2′‐Bipyridine: Characterization and antibacterial activities

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