Laminin-411 is a vascular ligand for MCAM and facilitates TH17 cell entry into the CNS.

Laminin-411 is a vascular ligand for MCAM and facilitates TH17 cell entry into the CNS.

TH17 cells enter tissues to facilitate pathogenic autoimmune responses, including multiple sclerosis (MS). However, the adhesion molecules involved in the unique migratory capacity of TH17 cells, into both inflamed and uninflamed tissues remain unclear. Herein, we characterize MCAM (CD146) as an adh...

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Autores principales: Ken Flanagan, Kent Fitzgerald, Jeanne Baker, Karin Regnstrom, Shyra Gardai, Frederique Bard, Simonetta Mocci, Pui Seto, Monica You, Catherine Larochelle, Alexandre Prat, Samuel Chow, Lauri Li, Chris Vandevert, Wagner Zago, Carlos Lorenzana, Christopher Nishioka, Jennifer Hoffman, Raquel Botelho, Christopher Willits, Kevin Tanaka, Jennifer Johnston, Ted Yednock
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/ce9517ea747141bb9e840827a0281c34
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