The SQSTM1/p62 UBA domain regulates Ajuba localisation, degradation and NF-κB signalling function

The SQSTM1/p62 UBA domain regulates Ajuba localisation, degradation and NF-κB signalling function

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The LIM-domain containing protein Ajuba and the scaffold protein SQSTM1/p62 regulate signalling of NF-κB, a transcription factor involved in osteoclast differentiation and survival. The ubiquitin-associated domain of SQSTM1/p62 is frequently mutated in patients with Paget’s disease of bone. Here, we...

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Autores principales: Melanie A. Sultana, Carmel Cluning, Wai-Sin Kwong, Nicole Polain, Nathan J. Pavlos, Thomas Ratajczak, John P. Walsh, Jiake Xu, Sarah L. Rea
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2021
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/ce95db131b1e48aea8e11c033670fb12
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