Human muscle-derived CLEC14A-positive cells regenerate muscle independent of PAX7

Skeletal muscle stem cells express the transcription factor Pax7. Here, the authors isolate, from human muscle, cells that are positive for the endothelial marker CLEC14A and show that despite not expressing pax7, these cells regenerate muscle and contribute to the muscle stem cell niche when transp...

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Autores principales:	Andreas Marg, Helena Escobar, Nikos Karaiskos, Stefanie A. Grunwald, Eric Metzler, Janine Kieshauer, Sascha Sauer, Diana Pasemann, Edoardo Malfatti, Dominique Mompoint, Susanna Quijano-Roy, Anastasiya Boltengagen, Joanna Schneider, Markus Schülke, Séverine Kunz, Robert Carlier, Carmen Birchmeier, Helge Amthor, Andreas Spuler, Christine Kocks, Nikolaus Rajewsky, Simone Spuler
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ce96cb57dae14384b0b97d2a3e6fda84
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spelling	oai:doaj.org-article:ce96cb57dae14384b0b97d2a3e6fda842021-12-02T17:02:12ZHuman muscle-derived CLEC14A-positive cells regenerate muscle independent of PAX710.1038/s41467-019-13650-z2041-1723https://doaj.org/article/ce96cb57dae14384b0b97d2a3e6fda842019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13650-zhttps://doaj.org/toc/2041-1723Skeletal muscle stem cells express the transcription factor Pax7. Here, the authors isolate, from human muscle, cells that are positive for the endothelial marker CLEC14A and show that despite not expressing pax7, these cells regenerate muscle and contribute to the muscle stem cell niche when transplanted into mice.Andreas MargHelena EscobarNikos KaraiskosStefanie A. GrunwaldEric MetzlerJanine KieshauerSascha SauerDiana PasemannEdoardo MalfattiDominique MompointSusanna Quijano-RoyAnastasiya BoltengagenJoanna SchneiderMarkus SchülkeSéverine KunzRobert CarlierCarmen BirchmeierHelge AmthorAndreas SpulerChristine KocksNikolaus RajewskySimone SpulerNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Andreas Marg Helena Escobar Nikos Karaiskos Stefanie A. Grunwald Eric Metzler Janine Kieshauer Sascha Sauer Diana Pasemann Edoardo Malfatti Dominique Mompoint Susanna Quijano-Roy Anastasiya Boltengagen Joanna Schneider Markus Schülke Séverine Kunz Robert Carlier Carmen Birchmeier Helge Amthor Andreas Spuler Christine Kocks Nikolaus Rajewsky Simone Spuler Human muscle-derived CLEC14A-positive cells regenerate muscle independent of PAX7
description	Skeletal muscle stem cells express the transcription factor Pax7. Here, the authors isolate, from human muscle, cells that are positive for the endothelial marker CLEC14A and show that despite not expressing pax7, these cells regenerate muscle and contribute to the muscle stem cell niche when transplanted into mice.
format	article
author	Andreas Marg Helena Escobar Nikos Karaiskos Stefanie A. Grunwald Eric Metzler Janine Kieshauer Sascha Sauer Diana Pasemann Edoardo Malfatti Dominique Mompoint Susanna Quijano-Roy Anastasiya Boltengagen Joanna Schneider Markus Schülke Séverine Kunz Robert Carlier Carmen Birchmeier Helge Amthor Andreas Spuler Christine Kocks Nikolaus Rajewsky Simone Spuler
author_facet	Andreas Marg Helena Escobar Nikos Karaiskos Stefanie A. Grunwald Eric Metzler Janine Kieshauer Sascha Sauer Diana Pasemann Edoardo Malfatti Dominique Mompoint Susanna Quijano-Roy Anastasiya Boltengagen Joanna Schneider Markus Schülke Séverine Kunz Robert Carlier Carmen Birchmeier Helge Amthor Andreas Spuler Christine Kocks Nikolaus Rajewsky Simone Spuler
author_sort	Andreas Marg
title	Human muscle-derived CLEC14A-positive cells regenerate muscle independent of PAX7
title_short	Human muscle-derived CLEC14A-positive cells regenerate muscle independent of PAX7
title_full	Human muscle-derived CLEC14A-positive cells regenerate muscle independent of PAX7
title_fullStr	Human muscle-derived CLEC14A-positive cells regenerate muscle independent of PAX7
title_full_unstemmed	Human muscle-derived CLEC14A-positive cells regenerate muscle independent of PAX7
title_sort	human muscle-derived clec14a-positive cells regenerate muscle independent of pax7
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/ce96cb57dae14384b0b97d2a3e6fda84
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Human muscle-derived CLEC14A-positive cells regenerate muscle independent of PAX7

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