Pan-cancer analysis of transcriptional metabolic dysregulation using The Cancer Genome Atlas

Metabolism is frequently dysregulated in cancer. Here, the authors conduct a pan-cancer analysis of The Cancer Genome Atlas to determine significant metabolic pathway alterations, highlight master metabolic transcriptional regulators, and predict patient response to metabolism targeted-therapeutics

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Detalles Bibliográficos
Autores principales: S. R. Rosario, M. D. Long, H. C. Affronti, A. M. Rowsam, K. H. Eng, D. J. Smiraglia
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/ce96fd232aac40bf8ffdc092b138dab3
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Descripción
Sumario:Metabolism is frequently dysregulated in cancer. Here, the authors conduct a pan-cancer analysis of The Cancer Genome Atlas to determine significant metabolic pathway alterations, highlight master metabolic transcriptional regulators, and predict patient response to metabolism targeted-therapeutics