Cryo-EM structure of the polycystic kidney disease-like channel PKD2L1

Polycystic kidney disease 2-like 1 protein (PKD2L1) is a voltage-dependent calcium-dependent nonselective ion channel involved in sour taste perception and regulation of pH-dependent action potential of spinal cord neurons. Here the authors present the 3.4 Å cryo-EM structure of PKD2L1 in the open s...

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Autores principales:	Qiang Su, Feizhuo Hu, Yuxia Liu, Xiaofei Ge, Changlin Mei, Shengqiang Yu, Aiwen Shen, Qiang Zhou, Chuangye Yan, Jianlin Lei, Yanqing Zhang, Xiaodong Liu, Tingliang Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ce9827ec7c7d442e97b9327ed4729e19
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spelling	oai:doaj.org-article:ce9827ec7c7d442e97b9327ed4729e192021-12-02T16:56:43ZCryo-EM structure of the polycystic kidney disease-like channel PKD2L110.1038/s41467-018-03606-02041-1723https://doaj.org/article/ce9827ec7c7d442e97b9327ed4729e192018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03606-0https://doaj.org/toc/2041-1723Polycystic kidney disease 2-like 1 protein (PKD2L1) is a voltage-dependent calcium-dependent nonselective ion channel involved in sour taste perception and regulation of pH-dependent action potential of spinal cord neurons. Here the authors present the 3.4 Å cryo-EM structure of PKD2L1 in the open state and propose a model for the gating mechanism.Qiang SuFeizhuo HuYuxia LiuXiaofei GeChanglin MeiShengqiang YuAiwen ShenQiang ZhouChuangye YanJianlin LeiYanqing ZhangXiaodong LiuTingliang WangNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Qiang Su Feizhuo Hu Yuxia Liu Xiaofei Ge Changlin Mei Shengqiang Yu Aiwen Shen Qiang Zhou Chuangye Yan Jianlin Lei Yanqing Zhang Xiaodong Liu Tingliang Wang Cryo-EM structure of the polycystic kidney disease-like channel PKD2L1
description	Polycystic kidney disease 2-like 1 protein (PKD2L1) is a voltage-dependent calcium-dependent nonselective ion channel involved in sour taste perception and regulation of pH-dependent action potential of spinal cord neurons. Here the authors present the 3.4 Å cryo-EM structure of PKD2L1 in the open state and propose a model for the gating mechanism.
format	article
author	Qiang Su Feizhuo Hu Yuxia Liu Xiaofei Ge Changlin Mei Shengqiang Yu Aiwen Shen Qiang Zhou Chuangye Yan Jianlin Lei Yanqing Zhang Xiaodong Liu Tingliang Wang
author_facet	Qiang Su Feizhuo Hu Yuxia Liu Xiaofei Ge Changlin Mei Shengqiang Yu Aiwen Shen Qiang Zhou Chuangye Yan Jianlin Lei Yanqing Zhang Xiaodong Liu Tingliang Wang
author_sort	Qiang Su
title	Cryo-EM structure of the polycystic kidney disease-like channel PKD2L1
title_short	Cryo-EM structure of the polycystic kidney disease-like channel PKD2L1
title_full	Cryo-EM structure of the polycystic kidney disease-like channel PKD2L1
title_fullStr	Cryo-EM structure of the polycystic kidney disease-like channel PKD2L1
title_full_unstemmed	Cryo-EM structure of the polycystic kidney disease-like channel PKD2L1
title_sort	cryo-em structure of the polycystic kidney disease-like channel pkd2l1
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/ce9827ec7c7d442e97b9327ed4729e19
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_version_	1718382769728389120

Cryo-EM structure of the polycystic kidney disease-like channel PKD2L1

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