Effects of airway management and tidal volume feedback ventilation during pediatric resuscitation in piglets with asphyxial cardiac arrest

Abstract To compare the effect on the recovery of spontaneous circulation (ROSC) of early endotracheal intubation (ETI) versus bag-mask ventilation (BMV), and expiratory real-time tidal volume (VTe) feedback (TVF) ventilation versus without feedback or standard ventilation (SV) in a pediatric animal...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Gema Manrique, Gema Pérez, Laura Butragueño-Laiseca, Miriam García, María Slöcker, Rafael González, Laura Herrera, Santiago Mencía, Jimena del Castillo, María José Solana, Débora Sanz, Raquel Cieza, Sarah N. Fernández, Jorge López, Javier Urbano, Jesús López-Herce
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ce9b3f8168c74ee2978cee091926dfbf
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ce9b3f8168c74ee2978cee091926dfbf
record_format	dspace
spelling	oai:doaj.org-article:ce9b3f8168c74ee2978cee091926dfbf2021-12-02T19:06:36ZEffects of airway management and tidal volume feedback ventilation during pediatric resuscitation in piglets with asphyxial cardiac arrest10.1038/s41598-021-95296-w2045-2322https://doaj.org/article/ce9b3f8168c74ee2978cee091926dfbf2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95296-whttps://doaj.org/toc/2045-2322Abstract To compare the effect on the recovery of spontaneous circulation (ROSC) of early endotracheal intubation (ETI) versus bag-mask ventilation (BMV), and expiratory real-time tidal volume (VTe) feedback (TVF) ventilation versus without feedback or standard ventilation (SV) in a pediatric animal model of asphyxial cardiac arrest. Piglets were randomized into five groups: 1: ETI and TVF ventilation (10 ml/kg); 2: ETI and TVF (7 ml/kg); 3: ETI and SV; 4: BMV and TVF (10 ml/kg) and 5: BMV and SV. Thirty breaths-per-minute guided by metronome were given. ROSC, pCO2, pO2, EtCO2 and VTe were compared among groups. Seventy-nine piglets (11.3 ± 1.2 kg) were included. Twenty-six (32.9%) achieved ROSC. Survival was non-significantly higher in ETI (40.4%) than BMV groups (21.9%), p = 0.08. No differences in ROSC were found between TVF and SV groups (30.0% versus 34.7%, p = 0.67). ETI groups presented lower pCO2, and higher pO2, EtCO2 and VTe than BMV groups (p < 0.05). VTe was lower in TVF than in SV groups and in BMV than in ETI groups (p < 0.05). Groups 1 and 3 showed higher pO2 and lower pCO2 over time, although with hyperventilation values (pCO2 < 35 mmHg). ETI groups had non significantly higher survival rate than BMV groups. Compared to BMV groups, ETI groups achieved better oxygenation and ventilation parameters. VTe was lower in both TVF and BMV groups. Hyperventilation was observed in intubated animals with SV and with 10 ml/kg VTF.Gema ManriqueGema PérezLaura Butragueño-LaisecaMiriam GarcíaMaría SlöckerRafael GonzálezLaura HerreraSantiago MencíaJimena del CastilloMaría José SolanaDébora SanzRaquel CiezaSarah N. FernándezJorge LópezJavier UrbanoJesús López-HerceNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Gema Manrique Gema Pérez Laura Butragueño-Laiseca Miriam García María Slöcker Rafael González Laura Herrera Santiago Mencía Jimena del Castillo María José Solana Débora Sanz Raquel Cieza Sarah N. Fernández Jorge López Javier Urbano Jesús López-Herce Effects of airway management and tidal volume feedback ventilation during pediatric resuscitation in piglets with asphyxial cardiac arrest
description	Abstract To compare the effect on the recovery of spontaneous circulation (ROSC) of early endotracheal intubation (ETI) versus bag-mask ventilation (BMV), and expiratory real-time tidal volume (VTe) feedback (TVF) ventilation versus without feedback or standard ventilation (SV) in a pediatric animal model of asphyxial cardiac arrest. Piglets were randomized into five groups: 1: ETI and TVF ventilation (10 ml/kg); 2: ETI and TVF (7 ml/kg); 3: ETI and SV; 4: BMV and TVF (10 ml/kg) and 5: BMV and SV. Thirty breaths-per-minute guided by metronome were given. ROSC, pCO2, pO2, EtCO2 and VTe were compared among groups. Seventy-nine piglets (11.3 ± 1.2 kg) were included. Twenty-six (32.9%) achieved ROSC. Survival was non-significantly higher in ETI (40.4%) than BMV groups (21.9%), p = 0.08. No differences in ROSC were found between TVF and SV groups (30.0% versus 34.7%, p = 0.67). ETI groups presented lower pCO2, and higher pO2, EtCO2 and VTe than BMV groups (p < 0.05). VTe was lower in TVF than in SV groups and in BMV than in ETI groups (p < 0.05). Groups 1 and 3 showed higher pO2 and lower pCO2 over time, although with hyperventilation values (pCO2 < 35 mmHg). ETI groups had non significantly higher survival rate than BMV groups. Compared to BMV groups, ETI groups achieved better oxygenation and ventilation parameters. VTe was lower in both TVF and BMV groups. Hyperventilation was observed in intubated animals with SV and with 10 ml/kg VTF.
format	article
author	Gema Manrique Gema Pérez Laura Butragueño-Laiseca Miriam García María Slöcker Rafael González Laura Herrera Santiago Mencía Jimena del Castillo María José Solana Débora Sanz Raquel Cieza Sarah N. Fernández Jorge López Javier Urbano Jesús López-Herce
author_facet	Gema Manrique Gema Pérez Laura Butragueño-Laiseca Miriam García María Slöcker Rafael González Laura Herrera Santiago Mencía Jimena del Castillo María José Solana Débora Sanz Raquel Cieza Sarah N. Fernández Jorge López Javier Urbano Jesús López-Herce
author_sort	Gema Manrique
title	Effects of airway management and tidal volume feedback ventilation during pediatric resuscitation in piglets with asphyxial cardiac arrest
title_short	Effects of airway management and tidal volume feedback ventilation during pediatric resuscitation in piglets with asphyxial cardiac arrest
title_full	Effects of airway management and tidal volume feedback ventilation during pediatric resuscitation in piglets with asphyxial cardiac arrest
title_fullStr	Effects of airway management and tidal volume feedback ventilation during pediatric resuscitation in piglets with asphyxial cardiac arrest
title_full_unstemmed	Effects of airway management and tidal volume feedback ventilation during pediatric resuscitation in piglets with asphyxial cardiac arrest
title_sort	effects of airway management and tidal volume feedback ventilation during pediatric resuscitation in piglets with asphyxial cardiac arrest
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ce9b3f8168c74ee2978cee091926dfbf
work_keys_str_mv	AT gemamanrique effectsofairwaymanagementandtidalvolumefeedbackventilationduringpediatricresuscitationinpigletswithasphyxialcardiacarrest AT gemaperez effectsofairwaymanagementandtidalvolumefeedbackventilationduringpediatricresuscitationinpigletswithasphyxialcardiacarrest AT laurabutraguenolaiseca effectsofairwaymanagementandtidalvolumefeedbackventilationduringpediatricresuscitationinpigletswithasphyxialcardiacarrest AT miriamgarcia effectsofairwaymanagementandtidalvolumefeedbackventilationduringpediatricresuscitationinpigletswithasphyxialcardiacarrest AT mariaslocker effectsofairwaymanagementandtidalvolumefeedbackventilationduringpediatricresuscitationinpigletswithasphyxialcardiacarrest AT rafaelgonzalez effectsofairwaymanagementandtidalvolumefeedbackventilationduringpediatricresuscitationinpigletswithasphyxialcardiacarrest AT lauraherrera effectsofairwaymanagementandtidalvolumefeedbackventilationduringpediatricresuscitationinpigletswithasphyxialcardiacarrest AT santiagomencia effectsofairwaymanagementandtidalvolumefeedbackventilationduringpediatricresuscitationinpigletswithasphyxialcardiacarrest AT jimenadelcastillo effectsofairwaymanagementandtidalvolumefeedbackventilationduringpediatricresuscitationinpigletswithasphyxialcardiacarrest AT mariajosesolana effectsofairwaymanagementandtidalvolumefeedbackventilationduringpediatricresuscitationinpigletswithasphyxialcardiacarrest AT deborasanz effectsofairwaymanagementandtidalvolumefeedbackventilationduringpediatricresuscitationinpigletswithasphyxialcardiacarrest AT raquelcieza effectsofairwaymanagementandtidalvolumefeedbackventilationduringpediatricresuscitationinpigletswithasphyxialcardiacarrest AT sarahnfernandez effectsofairwaymanagementandtidalvolumefeedbackventilationduringpediatricresuscitationinpigletswithasphyxialcardiacarrest AT jorgelopez effectsofairwaymanagementandtidalvolumefeedbackventilationduringpediatricresuscitationinpigletswithasphyxialcardiacarrest AT javierurbano effectsofairwaymanagementandtidalvolumefeedbackventilationduringpediatricresuscitationinpigletswithasphyxialcardiacarrest AT jesuslopezherce effectsofairwaymanagementandtidalvolumefeedbackventilationduringpediatricresuscitationinpigletswithasphyxialcardiacarrest
_version_	1718377176925995008

Effects of airway management and tidal volume feedback ventilation during pediatric resuscitation in piglets with asphyxial cardiac arrest

Ejemplares similares