MAVS-mediated apoptosis and its inhibition by viral proteins.

<h4>Background</h4>Host responses to viral infection include both immune activation and programmed cell death. The mitochondrial antiviral signaling adaptor, MAVS (IPS-1, VISA or Cardif) is critical for host defenses to viral infection by inducing type-1 interferons (IFN-I), however its...

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Autores principales:	Yu Lei, Chris B Moore, Rachael M Liesman, Brian P O'Connor, Daniel T Bergstralh, Zhijian J Chen, Raymond J Pickles, Jenny P-Y Ting
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2009
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ce9e45cacebe4770ab2eeb40d5b1b34b
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spelling	oai:doaj.org-article:ce9e45cacebe4770ab2eeb40d5b1b34b2021-11-25T06:23:08ZMAVS-mediated apoptosis and its inhibition by viral proteins.1932-620310.1371/journal.pone.0005466https://doaj.org/article/ce9e45cacebe4770ab2eeb40d5b1b34b2009-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19404494/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Host responses to viral infection include both immune activation and programmed cell death. The mitochondrial antiviral signaling adaptor, MAVS (IPS-1, VISA or Cardif) is critical for host defenses to viral infection by inducing type-1 interferons (IFN-I), however its role in virus-induced apoptotic responses has not been elucidated.<h4>Principal findings</h4>We show that MAVS causes apoptosis independent of its function in initiating IFN-I production. MAVS-induced cell death requires mitochondrial localization, is caspase dependent, and displays hallmarks of apoptosis. Furthermore, MAVS(-/-) fibroblasts are resistant to Sendai virus-induced apoptosis. A functional screen identifies the hepatitis C virus NS3/4A and the Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) nonstructural protein (NSP15) as inhibitors of MAVS-induced apoptosis, possibly as a method of immune evasion.<h4>Significance</h4>This study describes a novel role for MAVS in controlling viral infections through the induction of apoptosis, and identifies viral proteins which inhibit this host response.Yu LeiChris B MooreRachael M LiesmanBrian P O'ConnorDaniel T BergstralhZhijian J ChenRaymond J PicklesJenny P-Y TingPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 4, Iss 5, p e5466 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yu Lei Chris B Moore Rachael M Liesman Brian P O'Connor Daniel T Bergstralh Zhijian J Chen Raymond J Pickles Jenny P-Y Ting MAVS-mediated apoptosis and its inhibition by viral proteins.
description	<h4>Background</h4>Host responses to viral infection include both immune activation and programmed cell death. The mitochondrial antiviral signaling adaptor, MAVS (IPS-1, VISA or Cardif) is critical for host defenses to viral infection by inducing type-1 interferons (IFN-I), however its role in virus-induced apoptotic responses has not been elucidated.<h4>Principal findings</h4>We show that MAVS causes apoptosis independent of its function in initiating IFN-I production. MAVS-induced cell death requires mitochondrial localization, is caspase dependent, and displays hallmarks of apoptosis. Furthermore, MAVS(-/-) fibroblasts are resistant to Sendai virus-induced apoptosis. A functional screen identifies the hepatitis C virus NS3/4A and the Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) nonstructural protein (NSP15) as inhibitors of MAVS-induced apoptosis, possibly as a method of immune evasion.<h4>Significance</h4>This study describes a novel role for MAVS in controlling viral infections through the induction of apoptosis, and identifies viral proteins which inhibit this host response.
format	article
author	Yu Lei Chris B Moore Rachael M Liesman Brian P O'Connor Daniel T Bergstralh Zhijian J Chen Raymond J Pickles Jenny P-Y Ting
author_facet	Yu Lei Chris B Moore Rachael M Liesman Brian P O'Connor Daniel T Bergstralh Zhijian J Chen Raymond J Pickles Jenny P-Y Ting
author_sort	Yu Lei
title	MAVS-mediated apoptosis and its inhibition by viral proteins.
title_short	MAVS-mediated apoptosis and its inhibition by viral proteins.
title_full	MAVS-mediated apoptosis and its inhibition by viral proteins.
title_fullStr	MAVS-mediated apoptosis and its inhibition by viral proteins.
title_full_unstemmed	MAVS-mediated apoptosis and its inhibition by viral proteins.
title_sort	mavs-mediated apoptosis and its inhibition by viral proteins.
publisher	Public Library of Science (PLoS)
publishDate	2009
url	https://doaj.org/article/ce9e45cacebe4770ab2eeb40d5b1b34b
work_keys_str_mv	AT yulei mavsmediatedapoptosisanditsinhibitionbyviralproteins AT chrisbmoore mavsmediatedapoptosisanditsinhibitionbyviralproteins AT rachaelmliesman mavsmediatedapoptosisanditsinhibitionbyviralproteins AT brianpoconnor mavsmediatedapoptosisanditsinhibitionbyviralproteins AT danieltbergstralh mavsmediatedapoptosisanditsinhibitionbyviralproteins AT zhijianjchen mavsmediatedapoptosisanditsinhibitionbyviralproteins AT raymondjpickles mavsmediatedapoptosisanditsinhibitionbyviralproteins AT jennypyting mavsmediatedapoptosisanditsinhibitionbyviralproteins
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MAVS-mediated apoptosis and its inhibition by viral proteins.

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