Effect of arterial blood bicarbonate (HCO3 −) concentration on the accuracy of STOP-Bang questionnaire screening for obstructive sleep apnea

Abstract Background To evaluate the effect of arterial bicarbonate (HCO3 −) concentration on the accuracy of STOP-Bang questionnaire (SBQ) screening for obstructive sleep apnea (OSA). Methods A total of 144 patients with suspected OSA were included. Polysomnograms (PSG) and blood gas analysis were p...

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Autores principales:	Chong Pei, Shuyu Gui
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Obstructive sleep apnea Arterial blood HCO3 − concentration Polysomnograms STOP-Bang questionnaire Epworth Sleepiness Scale Berlin questionnaire Diseases of the respiratory system RC705-779
Acceso en línea:	https://doaj.org/article/cea050f0955e450c9e9f3814025258d8
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spelling	oai:doaj.org-article:cea050f0955e450c9e9f3814025258d82021-11-14T12:37:21ZEffect of arterial blood bicarbonate (HCO3 −) concentration on the accuracy of STOP-Bang questionnaire screening for obstructive sleep apnea10.1186/s12890-021-01720-21471-2466https://doaj.org/article/cea050f0955e450c9e9f3814025258d82021-11-01T00:00:00Zhttps://doi.org/10.1186/s12890-021-01720-2https://doaj.org/toc/1471-2466Abstract Background To evaluate the effect of arterial bicarbonate (HCO3 −) concentration on the accuracy of STOP-Bang questionnaire (SBQ) screening for obstructive sleep apnea (OSA). Methods A total of 144 patients with suspected OSA were included. Polysomnograms (PSG) and blood gas analysis were performed, and the Epworth Sleepiness Scale (ESS), STOP-Bang questionnaire, and Berlin questionnaire were completed. The correlation between the arterial HCO3 − concentration, apnea hypopnea index (AHI), and other related indicators was analyzed. The scoring results of the ESS, SBQ, and Berlin questionnaire were compared with the PSG results, and the sensitivity and specificity were calculated in the form of a four-cell table. The changes in the sensitivity and specificity of OSA screening after SBQ alone and combined with HCO3 − concentration were compared, and ROC curves were drawn. Results Arterial HCO3 − concentration was positively correlated with AHI (r = 0.537, P < 0.001). The ratio of HCO3 − concentration ≥ 24.6 mmol/L in the non-OSA group was significantly lower than that in the OSA group (25.0% VS 80.8%, P < 0.001). The sensitivity of the SBQ was higher than that of the ESS (97.5% VS 81.7%, P < 0.001) and the Berlin questionnaire (97.5% VS 79.2%, P < 0.001). There was no statistical significance in the specificity of the three scales (25%, 37.5%, 37.5%). A combined SBQ score ≥ 3 and HCO3 − concentration ≥ 24.6 mmol/L showed increased specificity and decreased sensitivity compared with an SBQ score ≥ 3 alone, with a corresponding AUC of 0.771 (P < 0.01) and 0.613 (P > 0.05), respectively. Conclusion The sensitivity of the SBQ was better than that of the Berlin questionnaire and ESS. After combining arterial blood HCO3 − concentration, the SBQ questionnaire increased the specificity of OSA prediction and decreased the sensitivity, which improved the accuracy of screening.Chong PeiShuyu GuiBMCarticleObstructive sleep apneaArterial blood HCO3 − concentrationPolysomnogramsSTOP-Bang questionnaireEpworth Sleepiness ScaleBerlin questionnaireDiseases of the respiratory systemRC705-779ENBMC Pulmonary Medicine, Vol 21, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Obstructive sleep apnea Arterial blood HCO3 − concentration Polysomnograms STOP-Bang questionnaire Epworth Sleepiness Scale Berlin questionnaire Diseases of the respiratory system RC705-779
spellingShingle	Obstructive sleep apnea Arterial blood HCO3 − concentration Polysomnograms STOP-Bang questionnaire Epworth Sleepiness Scale Berlin questionnaire Diseases of the respiratory system RC705-779 Chong Pei Shuyu Gui Effect of arterial blood bicarbonate (HCO3 −) concentration on the accuracy of STOP-Bang questionnaire screening for obstructive sleep apnea
description	Abstract Background To evaluate the effect of arterial bicarbonate (HCO3 −) concentration on the accuracy of STOP-Bang questionnaire (SBQ) screening for obstructive sleep apnea (OSA). Methods A total of 144 patients with suspected OSA were included. Polysomnograms (PSG) and blood gas analysis were performed, and the Epworth Sleepiness Scale (ESS), STOP-Bang questionnaire, and Berlin questionnaire were completed. The correlation between the arterial HCO3 − concentration, apnea hypopnea index (AHI), and other related indicators was analyzed. The scoring results of the ESS, SBQ, and Berlin questionnaire were compared with the PSG results, and the sensitivity and specificity were calculated in the form of a four-cell table. The changes in the sensitivity and specificity of OSA screening after SBQ alone and combined with HCO3 − concentration were compared, and ROC curves were drawn. Results Arterial HCO3 − concentration was positively correlated with AHI (r = 0.537, P < 0.001). The ratio of HCO3 − concentration ≥ 24.6 mmol/L in the non-OSA group was significantly lower than that in the OSA group (25.0% VS 80.8%, P < 0.001). The sensitivity of the SBQ was higher than that of the ESS (97.5% VS 81.7%, P < 0.001) and the Berlin questionnaire (97.5% VS 79.2%, P < 0.001). There was no statistical significance in the specificity of the three scales (25%, 37.5%, 37.5%). A combined SBQ score ≥ 3 and HCO3 − concentration ≥ 24.6 mmol/L showed increased specificity and decreased sensitivity compared with an SBQ score ≥ 3 alone, with a corresponding AUC of 0.771 (P < 0.01) and 0.613 (P > 0.05), respectively. Conclusion The sensitivity of the SBQ was better than that of the Berlin questionnaire and ESS. After combining arterial blood HCO3 − concentration, the SBQ questionnaire increased the specificity of OSA prediction and decreased the sensitivity, which improved the accuracy of screening.
format	article
author	Chong Pei Shuyu Gui
author_facet	Chong Pei Shuyu Gui
author_sort	Chong Pei
title	Effect of arterial blood bicarbonate (HCO3 −) concentration on the accuracy of STOP-Bang questionnaire screening for obstructive sleep apnea
title_short	Effect of arterial blood bicarbonate (HCO3 −) concentration on the accuracy of STOP-Bang questionnaire screening for obstructive sleep apnea
title_full	Effect of arterial blood bicarbonate (HCO3 −) concentration on the accuracy of STOP-Bang questionnaire screening for obstructive sleep apnea
title_fullStr	Effect of arterial blood bicarbonate (HCO3 −) concentration on the accuracy of STOP-Bang questionnaire screening for obstructive sleep apnea
title_full_unstemmed	Effect of arterial blood bicarbonate (HCO3 −) concentration on the accuracy of STOP-Bang questionnaire screening for obstructive sleep apnea
title_sort	effect of arterial blood bicarbonate (hco3 −) concentration on the accuracy of stop-bang questionnaire screening for obstructive sleep apnea
publisher	BMC
publishDate	2021
url	https://doaj.org/article/cea050f0955e450c9e9f3814025258d8
work_keys_str_mv	AT chongpei effectofarterialbloodbicarbonatehco3concentrationontheaccuracyofstopbangquestionnairescreeningforobstructivesleepapnea AT shuyugui effectofarterialbloodbicarbonatehco3concentrationontheaccuracyofstopbangquestionnairescreeningforobstructivesleepapnea
_version_	1718429132182781952

Effect of arterial blood bicarbonate (HCO3 −) concentration on the accuracy of STOP-Bang questionnaire screening for obstructive sleep apnea

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