Mechanism and Therapeutic Opportunities of Histone Modifications in Chronic Liver Disease

Chronic liver disease (CLD) represents a global health problem, accounting for the heavy burden of disability and increased health care utilization. Epigenome alterations play an important role in the occurrence and progression of CLD. Histone modifications, which include acetylation, methylation, a...

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Autores principales:	Qiuyu Cai, Can Gan, Chengwei Tang, Hao Wu, Jinhang Gao
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	histone acetylation histone methylation histone phosphorylation alcoholic liver disease metabolic associated fatty liver disease viral hepatitis Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/cea1b6f303bb4adab758462d65da203f
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spelling	oai:doaj.org-article:cea1b6f303bb4adab758462d65da203f2021-11-30T13:15:18ZMechanism and Therapeutic Opportunities of Histone Modifications in Chronic Liver Disease1663-981210.3389/fphar.2021.784591https://doaj.org/article/cea1b6f303bb4adab758462d65da203f2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphar.2021.784591/fullhttps://doaj.org/toc/1663-9812Chronic liver disease (CLD) represents a global health problem, accounting for the heavy burden of disability and increased health care utilization. Epigenome alterations play an important role in the occurrence and progression of CLD. Histone modifications, which include acetylation, methylation, and phosphorylation, represent an essential part of epigenetic modifications that affect the transcriptional activity of genes. Different from genetic mutations, histone modifications are plastic and reversible. They can be modulated pharmacologically without changing the DNA sequence. Thus, there might be chances to establish interventional solutions by targeting histone modifications to reverse CLD. Here we summarized the roles of histone modifications in the context of alcoholic liver disease (ALD), metabolic associated fatty liver disease (MAFLD), viral hepatitis, autoimmune liver disease, drug-induced liver injury (DILI), and liver fibrosis or cirrhosis. The potential targets of histone modifications for translation into therapeutics were also investigated. In prospect, high efficacy and low toxicity drugs that are selectively targeting histone modifications are required to completely reverse CLD and prevent the development of liver cirrhosis and malignancy.Qiuyu CaiQiuyu CaiCan GanCan GanChengwei TangChengwei TangHao WuJinhang GaoJinhang GaoFrontiers Media S.A.articlehistone acetylationhistone methylationhistone phosphorylationalcoholic liver diseasemetabolic associated fatty liver diseaseviral hepatitisTherapeutics. PharmacologyRM1-950ENFrontiers in Pharmacology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	histone acetylation histone methylation histone phosphorylation alcoholic liver disease metabolic associated fatty liver disease viral hepatitis Therapeutics. Pharmacology RM1-950
spellingShingle	histone acetylation histone methylation histone phosphorylation alcoholic liver disease metabolic associated fatty liver disease viral hepatitis Therapeutics. Pharmacology RM1-950 Qiuyu Cai Qiuyu Cai Can Gan Can Gan Chengwei Tang Chengwei Tang Hao Wu Jinhang Gao Jinhang Gao Mechanism and Therapeutic Opportunities of Histone Modifications in Chronic Liver Disease
description	Chronic liver disease (CLD) represents a global health problem, accounting for the heavy burden of disability and increased health care utilization. Epigenome alterations play an important role in the occurrence and progression of CLD. Histone modifications, which include acetylation, methylation, and phosphorylation, represent an essential part of epigenetic modifications that affect the transcriptional activity of genes. Different from genetic mutations, histone modifications are plastic and reversible. They can be modulated pharmacologically without changing the DNA sequence. Thus, there might be chances to establish interventional solutions by targeting histone modifications to reverse CLD. Here we summarized the roles of histone modifications in the context of alcoholic liver disease (ALD), metabolic associated fatty liver disease (MAFLD), viral hepatitis, autoimmune liver disease, drug-induced liver injury (DILI), and liver fibrosis or cirrhosis. The potential targets of histone modifications for translation into therapeutics were also investigated. In prospect, high efficacy and low toxicity drugs that are selectively targeting histone modifications are required to completely reverse CLD and prevent the development of liver cirrhosis and malignancy.
format	article
author	Qiuyu Cai Qiuyu Cai Can Gan Can Gan Chengwei Tang Chengwei Tang Hao Wu Jinhang Gao Jinhang Gao
author_facet	Qiuyu Cai Qiuyu Cai Can Gan Can Gan Chengwei Tang Chengwei Tang Hao Wu Jinhang Gao Jinhang Gao
author_sort	Qiuyu Cai
title	Mechanism and Therapeutic Opportunities of Histone Modifications in Chronic Liver Disease
title_short	Mechanism and Therapeutic Opportunities of Histone Modifications in Chronic Liver Disease
title_full	Mechanism and Therapeutic Opportunities of Histone Modifications in Chronic Liver Disease
title_fullStr	Mechanism and Therapeutic Opportunities of Histone Modifications in Chronic Liver Disease
title_full_unstemmed	Mechanism and Therapeutic Opportunities of Histone Modifications in Chronic Liver Disease
title_sort	mechanism and therapeutic opportunities of histone modifications in chronic liver disease
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/cea1b6f303bb4adab758462d65da203f
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Mechanism and Therapeutic Opportunities of Histone Modifications in Chronic Liver Disease

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