The Effect of Honey in Second Degree Burn Healing on Wistar Rats (Overview of Angiogenesis and the Number of Fibroblasts)

Introduction: Burn therapy is generally done using a burn ointment. However, honey can also be used as an alternative treatment for burns. Honey contains active flavonoid as an antioxidant and hydrogen peroxide which can stimulate fibroblasts proliferation also angiogenesis on burn healing phase. O...

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Autores principales:	Ayyasi Izaz Almaz, Ratna Dama Purnawati, Hermawan Istiadi, Neni susilaningsih
Formato:	article
Lenguaje:	EN
Publicado:	Universitas Sultan Agung Semarang 2020
Materias:	honey, flavonoid, antioxidant, angiogenesis Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/cea209cb4c1a4556b68e3dde250ca46f
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spelling	oai:doaj.org-article:cea209cb4c1a4556b68e3dde250ca46f2021-11-25T13:16:37ZThe Effect of Honey in Second Degree Burn Healing on Wistar Rats (Overview of Angiogenesis and the Number of Fibroblasts)2085-15452339-093X10.30659/sainsmed.v11i1.7614https://doaj.org/article/cea209cb4c1a4556b68e3dde250ca46f2020-09-01T00:00:00Zhttp://jurnal.unissula.ac.id/index.php/sainsmedika/article/view/7614https://doaj.org/toc/2085-1545https://doaj.org/toc/2339-093XIntroduction: Burn therapy is generally done using a burn ointment. However, honey can also be used as an alternative treatment for burns. Honey contains active flavonoid as an antioxidant and hydrogen peroxide which can stimulate fibroblasts proliferation also angiogenesis on burn healing phase. Objective: to determine the effect of honey in second degree burn healing from angiogenesis and the number of fibroblasts on Wistar rats. Methods: This research used a posttest only controlled group design on 15 rats with random selection and divided into 3 groups: H-G was given honey, B-G was given Bioplacenton®, N-G without any treatment after burn was induced. Rats were given a second degree burn in a size of 2 cm x 2cm on the back area and were treated twice a day for 14 days. Burn healing was measured by calculating the observation results of microscopic VEGF expression, the number of neovascularization, and the number of fibroblasts. Hypothesis analysis used Annova post hoc LSD and Mann-Whitney. Results: The highest mean in VEGF expression and the number of neovascularization was obtained from group B-G followed by group H-G and group N-G. Significant differences in the number of neovascularization between group B-G with group N-G, p<0.05. Conclusion: Honey can provide a healing effect on the second degree of burns in Wistar rats in terms of the number of neovascularization as well as Bioplacenton®Ayyasi Izaz AlmazRatna Dama PurnawatiHermawan IstiadiNeni susilaningsihUniversitas Sultan Agung Semarangarticlehoney, flavonoid, antioxidant, angiogenesisMedicine (General)R5-920ENSains Medika, Vol 11, Iss 1, Pp 27-32 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	honey, flavonoid, antioxidant, angiogenesis Medicine (General) R5-920
spellingShingle	honey, flavonoid, antioxidant, angiogenesis Medicine (General) R5-920 Ayyasi Izaz Almaz Ratna Dama Purnawati Hermawan Istiadi Neni susilaningsih The Effect of Honey in Second Degree Burn Healing on Wistar Rats (Overview of Angiogenesis and the Number of Fibroblasts)
description	Introduction: Burn therapy is generally done using a burn ointment. However, honey can also be used as an alternative treatment for burns. Honey contains active flavonoid as an antioxidant and hydrogen peroxide which can stimulate fibroblasts proliferation also angiogenesis on burn healing phase. Objective: to determine the effect of honey in second degree burn healing from angiogenesis and the number of fibroblasts on Wistar rats. Methods: This research used a posttest only controlled group design on 15 rats with random selection and divided into 3 groups: H-G was given honey, B-G was given Bioplacenton®, N-G without any treatment after burn was induced. Rats were given a second degree burn in a size of 2 cm x 2cm on the back area and were treated twice a day for 14 days. Burn healing was measured by calculating the observation results of microscopic VEGF expression, the number of neovascularization, and the number of fibroblasts. Hypothesis analysis used Annova post hoc LSD and Mann-Whitney. Results: The highest mean in VEGF expression and the number of neovascularization was obtained from group B-G followed by group H-G and group N-G. Significant differences in the number of neovascularization between group B-G with group N-G, p<0.05. Conclusion: Honey can provide a healing effect on the second degree of burns in Wistar rats in terms of the number of neovascularization as well as Bioplacenton®
format	article
author	Ayyasi Izaz Almaz Ratna Dama Purnawati Hermawan Istiadi Neni susilaningsih
author_facet	Ayyasi Izaz Almaz Ratna Dama Purnawati Hermawan Istiadi Neni susilaningsih
author_sort	Ayyasi Izaz Almaz
title	The Effect of Honey in Second Degree Burn Healing on Wistar Rats (Overview of Angiogenesis and the Number of Fibroblasts)
title_short	The Effect of Honey in Second Degree Burn Healing on Wistar Rats (Overview of Angiogenesis and the Number of Fibroblasts)
title_full	The Effect of Honey in Second Degree Burn Healing on Wistar Rats (Overview of Angiogenesis and the Number of Fibroblasts)
title_fullStr	The Effect of Honey in Second Degree Burn Healing on Wistar Rats (Overview of Angiogenesis and the Number of Fibroblasts)
title_full_unstemmed	The Effect of Honey in Second Degree Burn Healing on Wistar Rats (Overview of Angiogenesis and the Number of Fibroblasts)
title_sort	effect of honey in second degree burn healing on wistar rats (overview of angiogenesis and the number of fibroblasts)
publisher	Universitas Sultan Agung Semarang
publishDate	2020
url	https://doaj.org/article/cea209cb4c1a4556b68e3dde250ca46f
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The Effect of Honey in Second Degree Burn Healing on Wistar Rats (Overview of Angiogenesis and the Number of Fibroblasts)

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