Changes in the epidemiological characteristics of human brucellosis in Shaanxi Province from 2008 to 2020

Abstract In the present study, surveys of case numbers, constituent ratios, conventional biotyping, and multilocus sequence typing (MLST) were applied to characterize the incidence rate and epidemiological characteristics of human brucellosis in Shaanxi Province, China. A total of 12,215 human bruce...

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Autores principales:	Cui-hong An, Zhi-guo Liu, Shou-min Nie, Yang-xin Sun, Suo-ping Fan, Bo-yan Luo, Zhenjun Li, Ji-ru Xu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cea77920b8694d6f8375e964da5ae250
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spelling	oai:doaj.org-article:cea77920b8694d6f8375e964da5ae2502021-12-02T15:29:03ZChanges in the epidemiological characteristics of human brucellosis in Shaanxi Province from 2008 to 202010.1038/s41598-021-96774-x2045-2322https://doaj.org/article/cea77920b8694d6f8375e964da5ae2502021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96774-xhttps://doaj.org/toc/2045-2322Abstract In the present study, surveys of case numbers, constituent ratios, conventional biotyping, and multilocus sequence typing (MLST) were applied to characterize the incidence rate and epidemiological characteristics of human brucellosis in Shaanxi Province, China. A total of 12,215 human brucellosis cases were reported during 2008–2020, for an annual average incidence rate of 2.48/100,000. The most significant change was that the county numbers of reported cases increased from 36 in 2008 to 84 in 2020, with a geographic expansion trend from northern Shaanxi to Guanzhong, and southern Shaanxi regions; the incidence rate declined in previous epidemic northern Shaanxi regions while increasing each year in Guanzhong and southern Shaanxi regions such as Hancheng and Xianyang. The increased incidence was closely related to the development of large-scale small ruminants (goats and sheep) farms in Guanzhong and some southern Shaanxi regions. Another significant feature was that student cases (n = 261) were ranked second among all occupations, accounting for 2.14% of the total number of cases, with the majority due to drinking unsterilized goat milk. Three Brucella species were detected (B. melitensis (bv. 1, 2, 3 and variant), B. abortus bv. 3/6, and B. suis bv. 1) and were mainly distributed in the northern Shaanxi and Guanzhong regions. Three known STs (ST8, ST2, and ST14) were identified based on MLST analysis. The characteristics that had not changed were that B. melitensis strains belonging to the ST8 population were the dominant species and were observed in all nine regions during the examined periods. Strengthened human and animal brucellosis surveillance and restriction of the transfer of infected sheep (goats) as well as students avoiding drinking raw milk are suggested as optimal control strategies.Cui-hong AnZhi-guo LiuShou-min NieYang-xin SunSuo-ping FanBo-yan LuoZhenjun LiJi-ru XuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Cui-hong An Zhi-guo Liu Shou-min Nie Yang-xin Sun Suo-ping Fan Bo-yan Luo Zhenjun Li Ji-ru Xu Changes in the epidemiological characteristics of human brucellosis in Shaanxi Province from 2008 to 2020
description	Abstract In the present study, surveys of case numbers, constituent ratios, conventional biotyping, and multilocus sequence typing (MLST) were applied to characterize the incidence rate and epidemiological characteristics of human brucellosis in Shaanxi Province, China. A total of 12,215 human brucellosis cases were reported during 2008–2020, for an annual average incidence rate of 2.48/100,000. The most significant change was that the county numbers of reported cases increased from 36 in 2008 to 84 in 2020, with a geographic expansion trend from northern Shaanxi to Guanzhong, and southern Shaanxi regions; the incidence rate declined in previous epidemic northern Shaanxi regions while increasing each year in Guanzhong and southern Shaanxi regions such as Hancheng and Xianyang. The increased incidence was closely related to the development of large-scale small ruminants (goats and sheep) farms in Guanzhong and some southern Shaanxi regions. Another significant feature was that student cases (n = 261) were ranked second among all occupations, accounting for 2.14% of the total number of cases, with the majority due to drinking unsterilized goat milk. Three Brucella species were detected (B. melitensis (bv. 1, 2, 3 and variant), B. abortus bv. 3/6, and B. suis bv. 1) and were mainly distributed in the northern Shaanxi and Guanzhong regions. Three known STs (ST8, ST2, and ST14) were identified based on MLST analysis. The characteristics that had not changed were that B. melitensis strains belonging to the ST8 population were the dominant species and were observed in all nine regions during the examined periods. Strengthened human and animal brucellosis surveillance and restriction of the transfer of infected sheep (goats) as well as students avoiding drinking raw milk are suggested as optimal control strategies.
format	article
author	Cui-hong An Zhi-guo Liu Shou-min Nie Yang-xin Sun Suo-ping Fan Bo-yan Luo Zhenjun Li Ji-ru Xu
author_facet	Cui-hong An Zhi-guo Liu Shou-min Nie Yang-xin Sun Suo-ping Fan Bo-yan Luo Zhenjun Li Ji-ru Xu
author_sort	Cui-hong An
title	Changes in the epidemiological characteristics of human brucellosis in Shaanxi Province from 2008 to 2020
title_short	Changes in the epidemiological characteristics of human brucellosis in Shaanxi Province from 2008 to 2020
title_full	Changes in the epidemiological characteristics of human brucellosis in Shaanxi Province from 2008 to 2020
title_fullStr	Changes in the epidemiological characteristics of human brucellosis in Shaanxi Province from 2008 to 2020
title_full_unstemmed	Changes in the epidemiological characteristics of human brucellosis in Shaanxi Province from 2008 to 2020
title_sort	changes in the epidemiological characteristics of human brucellosis in shaanxi province from 2008 to 2020
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/cea77920b8694d6f8375e964da5ae250
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Changes in the epidemiological characteristics of human brucellosis in Shaanxi Province from 2008 to 2020

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