Trans-resveratrol-loaded nonionic lamellar liquid-crystalline systems: structural, rheological, mechanical, textural, and bioadhesive characterization and evaluation of in vivo anti-inflammatory activity

Bruno Fonseca-Santos,* Cínthia Yuka Satake,* Giovana Maria Fioramonti Calixto,* Aline Martins dos Santos, Marlus Chorilli School of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara, São Paulo, Brazil *These authors contributed equally to&...

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Autores principales:	Fonseca-Santos B, Satake CY, Calixto GMF, Santos AM, Chorilli M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	lamellar mesophase liquid crystals anti-inflammatory properties topical delivery Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/cea7ebdf25764884ac12222953a31dcf
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spelling	oai:doaj.org-article:cea7ebdf25764884ac12222953a31dcf2021-12-02T02:42:31ZTrans-resveratrol-loaded nonionic lamellar liquid-crystalline systems: structural, rheological, mechanical, textural, and bioadhesive characterization and evaluation of in vivo anti-inflammatory activity1178-2013https://doaj.org/article/cea7ebdf25764884ac12222953a31dcf2017-09-01T00:00:00Zhttps://www.dovepress.com/trans-resveratrol-loaded-nonionic-lamellar-liquid-crystalline-systems--peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Bruno Fonseca-Santos,* Cínthia Yuka Satake,* Giovana Maria Fioramonti Calixto,* Aline Martins dos Santos, Marlus Chorilli School of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara, São Paulo, Brazil *These authors contributed equally to this work Abstract: Resveratrol (Res) is a common phytoalexin present in a few edible materials, such as grape skin, peanuts, and red wine. Evidence has shown the beneficial effects of Res on human health, which may be attributed to its anti-inflammatory activity. However, the poor aqueous solubility of Res limits its therapeutic effectiveness. Therefore, the use of nanostructured delivery systems for Res, such as liquid-crystalline systems, could be beneficial. In this study, we aimed to develop, characterize, and determine the in vivo effectiveness of Res-loaded liquid-crystalline systems. Systems containing copaiba balsam oil, polyethylene glycol-40 hydrogenated castor oil, and water were designed. Results of polarized light microscopy, small-angle X-ray scattering, texture-profile analysis, and flow-rheology analysis showed that the Res-loaded liquid-crystalline system had a lamellar structure, textural and mechanical (hardness, compressibility, and adhesiveness) properties, and behaved as a non-Newtonian fluid, showing pseudoplastic behavior upon skin application. Furthermore, all liquid-crystalline systems presented bioadhesive properties that may have assisted in maintaining the anti-inflammatory activity of Res, since the topical application of the Res-loaded lamellar mesophase liquid crystals resulted in edema inhibition in a carrageenan-induced paw-inflammation mouse model. Therefore, Res-loaded lamellar mesophases represent a promising new therapeutic approach for inhibition of skin inflammation. Keywords: lamellar mesophase, liquid crystals, anti-inflammatory properties, topical deliveryFonseca-Santos BSatake CYCalixto GMFSantos AMChorilli MDove Medical Pressarticlelamellar mesophaseliquid crystalsanti-inflammatory propertiestopical deliveryMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 6883-6893 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	lamellar mesophase liquid crystals anti-inflammatory properties topical delivery Medicine (General) R5-920
spellingShingle	lamellar mesophase liquid crystals anti-inflammatory properties topical delivery Medicine (General) R5-920 Fonseca-Santos B Satake CY Calixto GMF Santos AM Chorilli M Trans-resveratrol-loaded nonionic lamellar liquid-crystalline systems: structural, rheological, mechanical, textural, and bioadhesive characterization and evaluation of in vivo anti-inflammatory activity
description	Bruno Fonseca-Santos,* Cínthia Yuka Satake,* Giovana Maria Fioramonti Calixto,* Aline Martins dos Santos, Marlus Chorilli School of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara, São Paulo, Brazil *These authors contributed equally to this work Abstract: Resveratrol (Res) is a common phytoalexin present in a few edible materials, such as grape skin, peanuts, and red wine. Evidence has shown the beneficial effects of Res on human health, which may be attributed to its anti-inflammatory activity. However, the poor aqueous solubility of Res limits its therapeutic effectiveness. Therefore, the use of nanostructured delivery systems for Res, such as liquid-crystalline systems, could be beneficial. In this study, we aimed to develop, characterize, and determine the in vivo effectiveness of Res-loaded liquid-crystalline systems. Systems containing copaiba balsam oil, polyethylene glycol-40 hydrogenated castor oil, and water were designed. Results of polarized light microscopy, small-angle X-ray scattering, texture-profile analysis, and flow-rheology analysis showed that the Res-loaded liquid-crystalline system had a lamellar structure, textural and mechanical (hardness, compressibility, and adhesiveness) properties, and behaved as a non-Newtonian fluid, showing pseudoplastic behavior upon skin application. Furthermore, all liquid-crystalline systems presented bioadhesive properties that may have assisted in maintaining the anti-inflammatory activity of Res, since the topical application of the Res-loaded lamellar mesophase liquid crystals resulted in edema inhibition in a carrageenan-induced paw-inflammation mouse model. Therefore, Res-loaded lamellar mesophases represent a promising new therapeutic approach for inhibition of skin inflammation. Keywords: lamellar mesophase, liquid crystals, anti-inflammatory properties, topical delivery
format	article
author	Fonseca-Santos B Satake CY Calixto GMF Santos AM Chorilli M
author_facet	Fonseca-Santos B Satake CY Calixto GMF Santos AM Chorilli M
author_sort	Fonseca-Santos B
title	Trans-resveratrol-loaded nonionic lamellar liquid-crystalline systems: structural, rheological, mechanical, textural, and bioadhesive characterization and evaluation of in vivo anti-inflammatory activity
title_short	Trans-resveratrol-loaded nonionic lamellar liquid-crystalline systems: structural, rheological, mechanical, textural, and bioadhesive characterization and evaluation of in vivo anti-inflammatory activity
title_full	Trans-resveratrol-loaded nonionic lamellar liquid-crystalline systems: structural, rheological, mechanical, textural, and bioadhesive characterization and evaluation of in vivo anti-inflammatory activity
title_fullStr	Trans-resveratrol-loaded nonionic lamellar liquid-crystalline systems: structural, rheological, mechanical, textural, and bioadhesive characterization and evaluation of in vivo anti-inflammatory activity
title_full_unstemmed	Trans-resveratrol-loaded nonionic lamellar liquid-crystalline systems: structural, rheological, mechanical, textural, and bioadhesive characterization and evaluation of in vivo anti-inflammatory activity
title_sort	trans-resveratrol-loaded nonionic lamellar liquid-crystalline systems: structural, rheological, mechanical, textural, and bioadhesive characterization and evaluation of in vivo anti-inflammatory activity
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/cea7ebdf25764884ac12222953a31dcf
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_version_	1718402251036295168

Trans-resveratrol-loaded nonionic lamellar liquid-crystalline systems: structural, rheological, mechanical, textural, and bioadhesive characterization and evaluation of in vivo anti-inflammatory activity

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