Optic Disc Hemorrhage and Lamina Cribrosa Defects in Glaucoma Progression

Abstract Both disc hemorrhages (DH) and focal lamina cribrosa (LC) defects are recently considered as a progression factor in glaucoma. However, the clinical relevance of the presence of LC findings at the site of the DH has not yet been determined. We conducted a prospective study enrolling a total...

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Autores principales:	Hae-Young Lopilly Park, Jiyoung Lee, Younhea Jung, Chan Kee Park
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cea93362493349aba95cd56ac2f341ae
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spelling	oai:doaj.org-article:cea93362493349aba95cd56ac2f341ae2021-12-02T16:06:10ZOptic Disc Hemorrhage and Lamina Cribrosa Defects in Glaucoma Progression10.1038/s41598-017-03828-02045-2322https://doaj.org/article/cea93362493349aba95cd56ac2f341ae2017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03828-0https://doaj.org/toc/2045-2322Abstract Both disc hemorrhages (DH) and focal lamina cribrosa (LC) defects are recently considered as a progression factor in glaucoma. However, the clinical relevance of the presence of LC findings at the site of the DH has not yet been determined. We conducted a prospective study enrolling a total of 98 glaucoma eyes with DH and 37 OAG eyes with focal LC defect without DH to determine whether visual field (VF) progression differs according to the findings of the LC that had been evaluated by enhanced depth imaging (EDI) of optical coherence tomography (OCT) and its relationship with DH. Only the presence of focal LC defects was significantly different between the progressing and stable patients (P < 0.001). Baseline intraocular pressure (hazard ratio [HR], 1.076; P = 0.098) and the presence of focal LC defects at the DH site (HR, 2.620; P = 0.002) were found to be associated with VF progression. Glaucoma eyes with DH at the site of focal LC defects showed frequent and faster VF progression compared with DH not accompanied by LC alterations or LC alterations not accompanied by DH. Evaluating LC alterations in glaucoma eyes with DH may be important in predicting the progression of glaucoma.Hae-Young Lopilly ParkJiyoung LeeYounhea JungChan Kee ParkNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hae-Young Lopilly Park Jiyoung Lee Younhea Jung Chan Kee Park Optic Disc Hemorrhage and Lamina Cribrosa Defects in Glaucoma Progression
description	Abstract Both disc hemorrhages (DH) and focal lamina cribrosa (LC) defects are recently considered as a progression factor in glaucoma. However, the clinical relevance of the presence of LC findings at the site of the DH has not yet been determined. We conducted a prospective study enrolling a total of 98 glaucoma eyes with DH and 37 OAG eyes with focal LC defect without DH to determine whether visual field (VF) progression differs according to the findings of the LC that had been evaluated by enhanced depth imaging (EDI) of optical coherence tomography (OCT) and its relationship with DH. Only the presence of focal LC defects was significantly different between the progressing and stable patients (P < 0.001). Baseline intraocular pressure (hazard ratio [HR], 1.076; P = 0.098) and the presence of focal LC defects at the DH site (HR, 2.620; P = 0.002) were found to be associated with VF progression. Glaucoma eyes with DH at the site of focal LC defects showed frequent and faster VF progression compared with DH not accompanied by LC alterations or LC alterations not accompanied by DH. Evaluating LC alterations in glaucoma eyes with DH may be important in predicting the progression of glaucoma.
format	article
author	Hae-Young Lopilly Park Jiyoung Lee Younhea Jung Chan Kee Park
author_facet	Hae-Young Lopilly Park Jiyoung Lee Younhea Jung Chan Kee Park
author_sort	Hae-Young Lopilly Park
title	Optic Disc Hemorrhage and Lamina Cribrosa Defects in Glaucoma Progression
title_short	Optic Disc Hemorrhage and Lamina Cribrosa Defects in Glaucoma Progression
title_full	Optic Disc Hemorrhage and Lamina Cribrosa Defects in Glaucoma Progression
title_fullStr	Optic Disc Hemorrhage and Lamina Cribrosa Defects in Glaucoma Progression
title_full_unstemmed	Optic Disc Hemorrhage and Lamina Cribrosa Defects in Glaucoma Progression
title_sort	optic disc hemorrhage and lamina cribrosa defects in glaucoma progression
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/cea93362493349aba95cd56ac2f341ae
work_keys_str_mv	AT haeyounglopillypark opticdischemorrhageandlaminacribrosadefectsinglaucomaprogression AT jiyounglee opticdischemorrhageandlaminacribrosadefectsinglaucomaprogression AT younheajung opticdischemorrhageandlaminacribrosadefectsinglaucomaprogression AT chankeepark opticdischemorrhageandlaminacribrosadefectsinglaucomaprogression
_version_	1718385115013316608

Optic Disc Hemorrhage and Lamina Cribrosa Defects in Glaucoma Progression

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