Lymphocyte infiltration in CAPN5 autosomal dominant neovascular inflammatory vitreoretinopathy

Vinit B Mahajan,1,2 Jonathan H Lin31Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, IA, USA; 2Omics Laboratory, University of Iowa Hospitals and Clinics, Iowa City, IA, USA; 3Departments of Pathology and Ophthalmology, University of California San Diego, La Jolla, CA,...

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Autores principales:	Mahajan VB, Lin JH
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/ceab76d644cb47278856b543c230e5ea
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spelling	oai:doaj.org-article:ceab76d644cb47278856b543c230e5ea2021-12-02T04:26:22ZLymphocyte infiltration in CAPN5 autosomal dominant neovascular inflammatory vitreoretinopathy1177-54671177-5483https://doaj.org/article/ceab76d644cb47278856b543c230e5ea2013-07-01T00:00:00Zhttp://www.dovepress.com/lymphocyte-infiltration-in-capn5-autosomal-dominant-neovascular-inflam-a13545https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Vinit B Mahajan,1,2 Jonathan H Lin31Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, IA, USA; 2Omics Laboratory, University of Iowa Hospitals and Clinics, Iowa City, IA, USA; 3Departments of Pathology and Ophthalmology, University of California San Diego, La Jolla, CA, USAPurpose: To describe immunohistopathological findings in autosomal dominant neovascular inflammatory vitreoretinopathy (ADNIV).Methods: An enucleated eye specimen from a patient with Stage V ADNIV was examined using standard histopathological methods and lymphocyte markers.Results: A c.731T>C CAPN5 mutation resulted in a p.Leu244Pro substitution in calpain-5. The eye showed exudative retinal detachment and neovascularization, intraocular fibrosis, and features of phthisis bulbi. Chronic inflammatory CD3-positive cell infiltrates were identified throughout the uvea, vitreous and retina, consistent with chronic uveitis.Conclusion: Mutations in CAPN5 trigger autoimmune uveitis characterized by inflammatory T-cells and severe neovascularization.Keywords: autosomal dominant neovascular inflammatory vitreoretinopathy, ADNIV, CAPN5, uveitis, CD3Mahajan VBLin JHDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2013, Iss default, Pp 1339-1345 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Mahajan VB Lin JH Lymphocyte infiltration in CAPN5 autosomal dominant neovascular inflammatory vitreoretinopathy
description	Vinit B Mahajan,1,2 Jonathan H Lin31Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, IA, USA; 2Omics Laboratory, University of Iowa Hospitals and Clinics, Iowa City, IA, USA; 3Departments of Pathology and Ophthalmology, University of California San Diego, La Jolla, CA, USAPurpose: To describe immunohistopathological findings in autosomal dominant neovascular inflammatory vitreoretinopathy (ADNIV).Methods: An enucleated eye specimen from a patient with Stage V ADNIV was examined using standard histopathological methods and lymphocyte markers.Results: A c.731T>C CAPN5 mutation resulted in a p.Leu244Pro substitution in calpain-5. The eye showed exudative retinal detachment and neovascularization, intraocular fibrosis, and features of phthisis bulbi. Chronic inflammatory CD3-positive cell infiltrates were identified throughout the uvea, vitreous and retina, consistent with chronic uveitis.Conclusion: Mutations in CAPN5 trigger autoimmune uveitis characterized by inflammatory T-cells and severe neovascularization.Keywords: autosomal dominant neovascular inflammatory vitreoretinopathy, ADNIV, CAPN5, uveitis, CD3
format	article
author	Mahajan VB Lin JH
author_facet	Mahajan VB Lin JH
author_sort	Mahajan VB
title	Lymphocyte infiltration in CAPN5 autosomal dominant neovascular inflammatory vitreoretinopathy
title_short	Lymphocyte infiltration in CAPN5 autosomal dominant neovascular inflammatory vitreoretinopathy
title_full	Lymphocyte infiltration in CAPN5 autosomal dominant neovascular inflammatory vitreoretinopathy
title_fullStr	Lymphocyte infiltration in CAPN5 autosomal dominant neovascular inflammatory vitreoretinopathy
title_full_unstemmed	Lymphocyte infiltration in CAPN5 autosomal dominant neovascular inflammatory vitreoretinopathy
title_sort	lymphocyte infiltration in capn5 autosomal dominant neovascular inflammatory vitreoretinopathy
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/ceab76d644cb47278856b543c230e5ea
work_keys_str_mv	AT mahajanvb lymphocyteinfiltrationincapn5autosomaldominantneovascularinflammatoryvitreoretinopathy AT linjh lymphocyteinfiltrationincapn5autosomaldominantneovascularinflammatoryvitreoretinopathy
_version_	1718401218176352256

Lymphocyte infiltration in CAPN5 autosomal dominant neovascular inflammatory vitreoretinopathy

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