rTMS induced tinnitus relief is related to an increase in auditory cortical alpha activity.

Chronic tinnitus, the continuous perception of a phantom sound, is a highly prevalent audiological symptom. A promising approach for the treatment of tinnitus is repetitive transcranial magnetic stimulation (rTMS) as this directly affects tinnitus-related brain activity. Several studies indeed show...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Nadia Müller, Isabel Lorenz, Berthold Langguth, Nathan Weisz
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ceac176ee71e46f996ed9f810035ad95
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ceac176ee71e46f996ed9f810035ad95
record_format	dspace
spelling	oai:doaj.org-article:ceac176ee71e46f996ed9f810035ad952021-11-18T07:58:52ZrTMS induced tinnitus relief is related to an increase in auditory cortical alpha activity.1932-620310.1371/journal.pone.0055557https://doaj.org/article/ceac176ee71e46f996ed9f810035ad952013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23390539/?tool=EBIhttps://doaj.org/toc/1932-6203Chronic tinnitus, the continuous perception of a phantom sound, is a highly prevalent audiological symptom. A promising approach for the treatment of tinnitus is repetitive transcranial magnetic stimulation (rTMS) as this directly affects tinnitus-related brain activity. Several studies indeed show tinnitus relief after rTMS, however effects are moderate and vary strongly across patients. This may be due to a lack of knowledge regarding how rTMS affects oscillatory activity in tinnitus sufferers and which modulations are associated with tinnitus relief. In the present study we examined the effects of five different stimulation protocols (including sham) by measuring tinnitus loudness and tinnitus-related brain activity with Magnetoencephalography before and after rTMS. Changes in oscillatory activity were analysed for the stimulated auditory cortex as well as for the entire brain regarding certain frequency bands of interest (delta, theta, alpha, gamma). In line with the literature the effects of rTMS on tinnitus loudness varied strongly across patients. This variability was also reflected in the rTMS effects on oscillatory activity. Importantly, strong reductions in tinnitus loudness were associated with increases in alpha power in the stimulated auditory cortex, while an unspecific decrease in gamma and alpha power, particularly in left frontal regions, was linked to an increase in tinnitus loudness. The identification of alpha power increase as main correlate for tinnitus reduction sheds further light on the pathophysiology of tinnitus. This will hopefully stimulate the development of more effective therapy approaches.Nadia MüllerIsabel LorenzBerthold LangguthNathan WeiszPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 2, p e55557 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nadia Müller Isabel Lorenz Berthold Langguth Nathan Weisz rTMS induced tinnitus relief is related to an increase in auditory cortical alpha activity.
description	Chronic tinnitus, the continuous perception of a phantom sound, is a highly prevalent audiological symptom. A promising approach for the treatment of tinnitus is repetitive transcranial magnetic stimulation (rTMS) as this directly affects tinnitus-related brain activity. Several studies indeed show tinnitus relief after rTMS, however effects are moderate and vary strongly across patients. This may be due to a lack of knowledge regarding how rTMS affects oscillatory activity in tinnitus sufferers and which modulations are associated with tinnitus relief. In the present study we examined the effects of five different stimulation protocols (including sham) by measuring tinnitus loudness and tinnitus-related brain activity with Magnetoencephalography before and after rTMS. Changes in oscillatory activity were analysed for the stimulated auditory cortex as well as for the entire brain regarding certain frequency bands of interest (delta, theta, alpha, gamma). In line with the literature the effects of rTMS on tinnitus loudness varied strongly across patients. This variability was also reflected in the rTMS effects on oscillatory activity. Importantly, strong reductions in tinnitus loudness were associated with increases in alpha power in the stimulated auditory cortex, while an unspecific decrease in gamma and alpha power, particularly in left frontal regions, was linked to an increase in tinnitus loudness. The identification of alpha power increase as main correlate for tinnitus reduction sheds further light on the pathophysiology of tinnitus. This will hopefully stimulate the development of more effective therapy approaches.
format	article
author	Nadia Müller Isabel Lorenz Berthold Langguth Nathan Weisz
author_facet	Nadia Müller Isabel Lorenz Berthold Langguth Nathan Weisz
author_sort	Nadia Müller
title	rTMS induced tinnitus relief is related to an increase in auditory cortical alpha activity.
title_short	rTMS induced tinnitus relief is related to an increase in auditory cortical alpha activity.
title_full	rTMS induced tinnitus relief is related to an increase in auditory cortical alpha activity.
title_fullStr	rTMS induced tinnitus relief is related to an increase in auditory cortical alpha activity.
title_full_unstemmed	rTMS induced tinnitus relief is related to an increase in auditory cortical alpha activity.
title_sort	rtms induced tinnitus relief is related to an increase in auditory cortical alpha activity.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/ceac176ee71e46f996ed9f810035ad95
work_keys_str_mv	AT nadiamuller rtmsinducedtinnitusreliefisrelatedtoanincreaseinauditorycorticalalphaactivity AT isabellorenz rtmsinducedtinnitusreliefisrelatedtoanincreaseinauditorycorticalalphaactivity AT bertholdlangguth rtmsinducedtinnitusreliefisrelatedtoanincreaseinauditorycorticalalphaactivity AT nathanweisz rtmsinducedtinnitusreliefisrelatedtoanincreaseinauditorycorticalalphaactivity
_version_	1718422696014905344

rTMS induced tinnitus relief is related to an increase in auditory cortical alpha activity.

Ejemplares similares